HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: GGA3 (Q9NZ52)
ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Gene: GGA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	29358589, 35384245
Identification Methods	pull down, proximity labelling technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0010008 - endosome membrane GO:0031901 - early endosome membrane GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 723
+	Hs
		339110 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GGA1_HUMAN (2-723): 1.09e-91: 301: 39.78
+	Hs
		276982 EGFR_HUMAN (1-1210): 0: 1241: 100.00		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		272785 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TM1L1_HUMAN (6-473): 8.9e-63: 219: 16.50
+	Hs
		159830 EGFR_HUMAN (1-1210): 0: 1241: 100.00		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		212580 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G1_HUMAN (503-720): 2.89e-51: 193: 26.96
+	Hs
		339109 EGFR_HUMAN (1-1210): 0: 1241: 100.00		GGA2_HUMAN (456-721): 1.1e-25: 114: 34.83
+	Hs
		276351 EGFR_HUMAN (1-1210): 0: 1241: 100.00		AP1G2_HUMAN (602-720): 5.74e-10: 64.7: 32.77
+	Hs
		159886 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		434297 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		GGA3_HUMAN (1-723): 3.49e-148: 451: 100.00
+	Hs
		276988 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		277037 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		277152 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		277067 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		277010 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		STAM2_HUMAN (1-480): 4.23e-79: 264: 16.95
+	Hs
		159848 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		159938 EPHA4_HUMAN (660-1016): 3.35e-120: 398: 31.52		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		159900 EPHB2_HUMAN (642-1067): 4.6e-119: 397: 28.76		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		160216 EPHA6_HUMAN (629-1016): 8.37e-118: 393: 27.80		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		160004 EPHA7_HUMAN (653-1072): 5.04e-118: 392: 27.23		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37
+	Hs
		159897 EPHA2_HUMAN (665-1016): 5.77e-117: 389: 32.79		HGS_HUMAN (8-709): 5.07e-58: 212: 13.37