HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: ARHGC (Q9NZN5)
Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
Gene: ARHGEF12

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16565089
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 1544
+	Hs
		338801 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG2_HUMAN (557-1462): 1.89e-101: 351: 17.54
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (714-1294): 8.13e-94: 325: 16.38
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (673-1294): 1.01e-96: 334: 15.63
+	Hs
		338823 EGFR_HUMAN (1-1210): 0: 1241: 100.00		Q96D37_HUMAN (673-1294): 3.02e-97: 334: 15.63
+	Hs
		338167 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81
+	Hs
		339058 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN2_HUMAN (608-1282): 4.01e-84: 307: 19.15
+	Hs
		338478 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ITSN1_HUMAN (118-1216): 2.17e-82: 302: 13.70
+	Hs
		338419 EGFR_HUMAN (1-1210): 0: 1241: 100.00		ARHG7_HUMAN (656-1340): 4.14e-85: 299: 12.38
+	Hs
		339121 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV3_HUMAN (726-1293): 4.2e-84: 297: 13.29
+	Hs
		548711 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV_HUMAN (673-1294): 1.01e-96: 334: 15.63
+	Hs
		383913 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		ARHG2_HUMAN (557-1462): 1.89e-101: 351: 17.54
+	Hs
		855797 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81
+	Hs
		383580 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV_HUMAN (673-1294): 1.01e-96: 334: 15.63
+	Hs
		383927 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		Q96D37_HUMAN (673-1294): 3.02e-97: 334: 15.63
+	Hs
		383705 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81
+	Hs
		1071026 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		VAV3_HUMAN (726-1293): 4.2e-84: 297: 13.29
+	Hs
		548637 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV_HUMAN (673-1294): 1.01e-96: 334: 15.63
+	Hs
		224717 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		KALRN_HUMAN (776-1440): 2.07e-72: 271: 14.64
+	Hs
		384022 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		VAV3_HUMAN (726-1293): 4.2e-84: 297: 13.29
+	Hs
		601860 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		VAV2_HUMAN (714-1339): 2.94e-93: 325: 13.81