Protein: MPIP3
M-phase inducer phosphatase 3 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25C)

Gene: MPIP3, CDC25C
Organism: Homo sapiens
Interactions: 149
UniProt ID: P30307

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0004721 - phosphoprotein phosphatase activity
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163056

CHK1
Serine/threonine-protein kinase Chk1

17

3

Small-scale

0.987

High

354916

CHK2
Serine/threonine-protein kinase Chk2

14

4

Small-scale

0.983

High

719299

PLK1
Serine/threonine-protein kinase PLK1

8

3

Small-scale

0.976

High

443212

CDK1
Cyclin-dependent kinase 1

5

18

Small-scale

0.924

High

692002

MARK3
MAP/microtubule affinity-regulating kinase 3

4

3

Small-scale

0.904

High

667573

CDK2
Cyclin-dependent kinase 2

3

18

Small-scale

0.845

High

719371

PLK3
Serine/threonine-protein kinase PLK3

2

4

Small-scale

0.843

High

703451

MK01
Mitogen-activated protein kinase 1

2

5

Small-scale

0.806

High

719331

MK14
Mitogen-activated protein kinase 14

2

12

Small-scale

0.789

High

719297

MK09
Mitogen-activated protein kinase 9

2

10

Small-scale

0.768

High

719290

1433B
14-3-3 protein beta/alpha

16

20

Small-scale

0.763

High

719316

1433F
14-3-3 protein eta

10

20

Small-scale

0.756

High

719304

1433G
14-3-3 protein gamma

9

20

Small-scale

0.754

High

719305

1433E
14-3-3 protein epsilon

9

10

Small-scale

0.752

High

690760

1433T
14-3-3 protein theta

6

20

Small-scale

0.733

High

719307

1433Z
14-3-3 protein zeta/delta

6

20

Small-scale

0.730

High

691641

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.724

High

719364

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

Small-scale

0.724

High

719388

SUFU
Suppressor of fused homolog

5

2

High-throughput

0.718

High

719330

PKN1
Serine/threonine-protein kinase N1

1

0

Small-scale

0.708

High

719322

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

1

Small-scale

0.667

High

362835

EGFR
Epidermal growth factor receptor

3

3

High-throughput

0.664

High

719311

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.647

High

719312

CDK5
Cyclin-dependent kinase 5

1

18

Small-scale

0.647

High

719348

BRSK2
Serine/threonine-protein kinase BRSK2

1

2

Small-scale

0.647

High

719323

FHL1
Four and a half LIM domains protein 1

2

5

Small-scale

0.631

High

719332

CDC37
Hsp90 co-chaperone Cdc37

3

0

Small-scale

0.628

High

176802

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.618

High

245201

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

1

High-throughput

0.618

High

625210

CSK22
Casein kinase II subunit alpha'

1

15

High-throughput

0.618

High

719106

MPIP1
M-phase inducer phosphatase 1

1

3

Small-scale

0.618

High

719289

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.618

High

550871

PCNA
Proliferating cell nuclear antigen

2

0

Small-scale

0.605

High

711242

SHC1
SHC-transforming protein 1

2

0

High-throughput

0.602

High

719291

1433S
14-3-3 protein sigma

2

20

Small-scale

0.584

High

666949

CCNE1
G1/S-specific cyclin-E1

1

11

Small-scale

0.561

High

719326

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

2

0

Small-scale

0.559

High

719329

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

3

High-throughput

0.541

High

123603

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

227809

MYO1B
Unconventional myosin-Ib

1

1

High-throughput

0.536

High

325468

CCNB2
G2/mitotic-specific cyclin-B2

1

8

High-throughput

0.536

High

719358

RPGR
X-linked retinitis pigmentosa GTPase regulator

1

1

High-throughput

0.536

High

570847

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

719300

S12A2
Solute carrier family 12 member 2

1

0

High-throughput

0.513

High

719310

TPM4
Tropomyosin alpha-4 chain

1

0

High-throughput

0.513

High

719389

LZTS1
Leucine zipper putative tumor suppressor 1

1

0

Small-scale

0.513

High

719298

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

Small-scale

0.505

High

573762

CCNB1
G2/mitotic-specific cyclin-B1

1

9

Small-scale

0.501

High

719328

IMB1
Importin subunit beta-1

1

1

Small-scale

0.501

High

641495

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

4

High-throughput

0.494

High

719314

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

1

High-throughput

0.494

High

719349

LMTK2
Serine/threonine-protein kinase LMTK2

1

2

High-throughput

0.494

High

719333

ANR39
Ankyrin repeat domain-containing protein 39

1

1

High-throughput

0.489

High

719294

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.480

High

208625

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

1

High-throughput

0.479

High

229966

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.479

High

230507

KIF1C
Kinesin-like protein KIF1C

1

3

High-throughput

0.479

High

252017

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

269519

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

1

High-throughput

0.479

High

281288

GGYF1
GRB10-interacting GYF protein 1

1

2

High-throughput

0.479

High

281718

VP26A
Vacuolar protein sorting-associated protein 26A

1

1

High-throughput

0.479

High

339060

NADK
NAD kinase

1

1

High-throughput

0.479

High

342759

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

343903

HS74L
Heat shock 70 kDa protein 4L

1

1

High-throughput

0.479

High

461184

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

532390

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

637851

NF1
Neurofibromin

1

3

High-throughput

0.479

High

681756

RBTN2
Rhombotin-2

1

4

Small-scale

0.479

High

682007

RBTN1
Rhombotin-1

1

4

Small-scale

0.479

High

719292

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

719293

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

719295

CCNF
Cyclin-F

1

12

High-throughput

0.479

High

719296

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

719301

HDAC4
Histone deacetylase 4

1

2

High-throughput

0.479

High

719308

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.479

High

719317

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

2

High-throughput

0.479

High

719320

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

1

High-throughput

0.479

High

719321

ILK
Scaffold protein ILK

1

1

High-throughput

0.479

High

719324

FHL3
Four and a half LIM domains protein 3

1

5

Small-scale

0.479

High

719325

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.479

High

719327

ZN638
Zinc finger protein 638

1

1

High-throughput

0.479

High

719334

NU188
Nucleoporin NUP188

1

1

High-throughput

0.479

High

719335

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

1

High-throughput

0.479

High

719336

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.479

High

719337

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

719338

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

High-throughput

0.479

High

719339

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.479

High

719341

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

1

Small-scale

0.479

High

719342

GGYF2
GRB10-interacting GYF protein 2

1

4

High-throughput

0.479

High

719344

PHLB2
Pleckstrin homology-like domain family B member 2

1

3

High-throughput

0.479

High

719345

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

719347

KSR1
Kinase suppressor of Ras 1

1

4

High-throughput

0.479

High

719352

NAV1
Neuron navigator 1

1

1

High-throughput

0.479

High

719354

LMO3
LIM domain only protein 3

1

4

Small-scale

0.479

High

719355

DEN1A
DENN domain-containing protein 1A

1

3

High-throughput

0.479

High

719357

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

719362

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

2

High-throughput

0.479

High

719363

TESK2
Dual specificity testis-specific protein kinase 2

1

1

High-throughput

0.479

High

719365

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

719368

RTKN
Rhotekin

1

1

High-throughput

0.479

High

719372

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

719375

KI13B
Kinesin-like protein KIF13B

1

3

High-throughput

0.479

High

719381

LIMA1
LIM domain and actin-binding protein 1

1

1

High-throughput

0.479

High

719382

XPO7
Exportin-7

1

4

High-throughput

0.479

High

719383

NGAP
Ras GTPase-activating protein nGAP

1

3

High-throughput

0.479

High

719385

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.479

High

719386

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

719390

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

719391

STA13
StAR-related lipid transfer protein 13

1

2

High-throughput

0.479

High

637362

FLNA
Filamin-A

1

0

Small-scale

0.458

High

687753

SYVC
Valine--tRNA ligase

1

0

High-throughput

0.458

High

717690

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.458

High

719302

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.458

High

719303

S10AA
Protein S100-A10

1

0

High-throughput

0.458

High

719306

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.458

High

719309

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.458

High

719313

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

719315

LGUL
Lactoylglutathione lyase

1

0

High-throughput

0.458

High

719319

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

0

High-throughput

0.458

High

719346

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

Small-scale

0.458

High

719351

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.458

High

719353

FAD1
FAD synthase

1

0

High-throughput

0.458

High

719360

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

High-throughput

0.458

High

719366

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.458

High

719369

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

719370

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

719373

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.458

High

719376

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

719377

TBCC1
TBCC domain-containing protein 1

1

0

High-throughput

0.458

High

719393

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

0

High-throughput

0.458

High

719340

PHLB3
Pleckstrin homology-like domain family B member 3

1

2

High-throughput

0.437

High

719343

SYDE1
Rho GTPase-activating protein SYDE1

1

4

High-throughput

0.437

High

719356

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

2

High-throughput

0.437

High

719361

APLD1
Apolipoprotein L domain-containing protein 1

1

1

High-throughput

0.437

High

719374

TANC2
Protein TANC2

1

1

High-throughput

0.437

High

719379

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

1

High-throughput

0.437

High

719380

CING
Cingulin

1

1

High-throughput

0.437

High

719384

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.437

High

719392

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

719350

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

184123

RER1
Protein RER1

1

0

High-throughput

0.279

Low

719367

SWET1
Sugar transporter SWEET1

1

0

High-throughput

0.279

Low

719387

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.279

Low

719359

CDS1
Phosphatidate cytidylyltransferase 1

1

0

Small-scale

0.261

Low

163541

TPP1
Tripeptidyl-peptidase 1

1

0

High-throughput

0.249

Low

228803

SCO2
Protein SCO2 homolog, mitochondrial

1

0

High-throughput

0.249

Low

719378

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.249

Low

719318

F27E3
Protein FAM27E3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025