HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 575
+	Hs
		145963 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SH2B2_HUMAN (25-573): 1.06e-116: 361: 31.30
+	Rn
		94037 Q9QX70_RAT (1-1210): 0: 1241: 90.34		F1LN91_RAT (57-562): 7.05e-54: 199: 11.29
+	Mm
		403432 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SRC_MOUSE (204-539): 2.93e-45: 169: 13.01
+	Mm
		654977 EGFR_MOUSE (1-1210): 0: 1258: 90.35		VAV_MOUSE (192-573): 4.75e-44: 169: 11.00
+	Hs
		337872 EGFR_HUMAN (1-1210): 0: 1241: 100.00		VAV_HUMAN (192-573): 3.94e-49: 184: 11.77
+	Mm
		964559 EGFR_MOUSE (1-1210): 0: 1258: 90.35		GRB2_MOUSE (307-547): 1.13e-45: 162: 12.45
+	Hs
		337850 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Rn
		1351588 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SRC_RAT (204-539): 2.39e-45: 169: 13.01
+	Hs
		337789 EGFR_HUMAN (1-1210): 0: 1241: 100.00		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Rn
		924998 Q9QX70_RAT (1-1210): 0: 1241: 90.34		GRB2_RAT (307-547): 8.13e-46: 162: 12.86
+	Rn
		1129188 Q9QX70_RAT (1-1210): 0: 1241: 90.34		SHC1_RAT (248-462): 3.21e-40: 154: 21.85
+	Hs
		337884 EGFR_HUMAN (1-1210): 0: 1241: 100.00		FER_HUMAN (245-465): 2.17e-37: 149: 19.56
+	Hs
		337883 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK1_HUMAN (286-446): 2.61e-38: 147: 18.39
+	Hs
		208970 EGFR_HUMAN (1-1210): 0: 1241: 100.00		NCK2_HUMAN (237-453): 3.16e-38: 146: 16.07
+	Mm
		957227 EGFR_MOUSE (1-1210): 0: 1258: 90.35		SHC1_MOUSE (308-453): 3.05e-30: 126: 26.71
+	Hs
		338069 EGFR_HUMAN (1-1210): 0: 1241: 100.00		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		337988 EGFR_HUMAN (1-1210): 0: 1241: 100.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Hs
		338080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MATK_HUMAN (343-444): 6e-22: 101: 32.35
+	Hs
		337912 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129152 EGFR_HUMAN (1-1210): 0: 1241: 100.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38