Protein: NCOA1
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)

Gene: NCOA1
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q15788

Gene Ontology (top 5):
GO:0000435 - positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0002155 - regulation of thyroid hormone receptor signaling pathway
GO:0003682 - chromatin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

369684

ESR1
Estrogen receptor

34

20

Small-scale

0.993

High

740535

PPARG
Peroxisome proliferator-activated receptor gamma

24

20

Small-scale

0.989

High

587177

RXRA
Retinoic acid receptor RXR-alpha

15

20

Small-scale

0.983

High

487978

RARA
Retinoic acid receptor alpha

13

20

Small-scale

0.980

High

509959

VDR
Vitamin D3 receptor

10

20

Small-scale

0.972

High

265870

NR1I2
Nuclear receptor subfamily 1 group I member 2

10

20

Small-scale

0.971

High

786487

STAT6
Signal transducer and activator of transcription 6

7

10

Small-scale

0.968

High

1078530

CBP
CREB-binding protein

8

20

Small-scale

0.965

High

487473

ANDR
Androgen receptor

8

20

Small-scale

0.965

High

377354

GCR
Glucocorticoid receptor

10

20

Small-scale

0.965

High

1078529

ESR2
Estrogen receptor beta

9

20

Small-scale

0.964

High

500491

THB
Thyroid hormone receptor beta

8

20

Small-scale

0.963

High

992422

PPARA
Peroxisome proliferator-activated receptor alpha

7

20

Small-scale

0.955

High

500431

THA
Thyroid hormone receptor alpha

6

20

Small-scale

0.939

High

1078537

NR1H4
Bile acid receptor

5

20

Small-scale

0.922

High

975432

PPARD
Peroxisome proliferator-activated receptor delta

5

20

Small-scale

0.916

High

414508

PRGR
Progesterone receptor

5

20

Small-scale

0.907

High

1061326

NR1I3
Nuclear receptor subfamily 1 group I member 3

4

20

High-throughput

0.897

High

998754

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.882

High

1075370

NCOA2
Nuclear receptor coactivator 2

4

20

Small-scale

0.867

High

1025256

NR1H3
Oxysterols receptor LXR-alpha

3

20

Small-scale

0.850

High

500364

RARB
Retinoic acid receptor beta

3

20

Small-scale

0.840

High

130328

NR5A2
Nuclear receptor subfamily 5 group A member 2

3

20

Small-scale

0.833

High

510021

ERR1
Steroid hormone receptor ERR1

3

20

Small-scale

0.833

High

723179

RORA
Nuclear receptor ROR-alpha

3

20

Small-scale

0.833

High

728926

AHR
Aryl hydrocarbon receptor

2

20

Small-scale

0.821

High

611447

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

20

Small-scale

0.768

High

530798

RARG
Retinoic acid receptor gamma

2

20

Small-scale

0.767

High

914651

ERR3
Estrogen-related receptor gamma

2

20

Small-scale

0.767

High

437642

MCR
Mineralocorticoid receptor

2

20

Small-scale

0.757

High

1055255

HNF4G
Hepatocyte nuclear factor 4-gamma

2

20

Small-scale

0.754

High

1078516

Q58EY0
RAR related orphan receptor B isoform 1

2

20

Small-scale

0.754

High

1078553

NCOA3
Nuclear receptor coactivator 3

2

19

Small-scale

0.743

High

649119

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

20

Small-scale

0.740

High

345446

FOS
Protein c-Fos

3

11

Small-scale

0.674

High

1078531

KAT2B
Histone acetyltransferase KAT2B

3

12

Small-scale

0.672

High

863099

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

1

High-throughput

0.667

High

402069

JUN
Transcription factor Jun

3

13

Small-scale

0.662

High

1057762

NCOA6
Nuclear receptor coactivator 6

3

9

Small-scale

0.658

High

1078534

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

3

8

Small-scale

0.655

High

490063

NR2F6
Nuclear receptor subfamily 2 group F member 6

1

20

Small-scale

0.647

High

846416

RORG
Nuclear receptor ROR-gamma

1

20

Small-scale

0.647

High

1078515

HIF1A
Hypoxia-inducible factor 1-alpha

1

19

Small-scale

0.647

High

1078539

SLX1
Structure-specific endonuclease subunit SLX1

2

1

High-throughput

0.628

High

776697

STAT3
Signal transducer and activator of transcription 3

2

10

Small-scale

0.624

High

659718

RXRB
Retinoic acid receptor RXR-beta

1

20

High-throughput

0.621

High

782555

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

Small-scale

0.621

High

874384

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.621

High

1030588

STF1
Steroidogenic factor 1

1

20

Small-scale

0.621

High

1073358

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

20

Small-scale

0.621

High

799108

NKX21
Homeobox protein Nkx-2.1

2

15

Small-scale

0.619

High

795598

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.618

High

1078513

NCOA1
Nuclear receptor coactivator 1

1

19

Small-scale

0.618

High

536843

TRI27
Zinc finger protein RFP

2

5

High-throughput

0.606

High

587594

NFKB1
Nuclear factor NF-kappa-B p105 subunit

2

13

Small-scale

0.602

High

1078522

CARM1
Histone-arginine methyltransferase CARM1

2

8

Small-scale

0.602

High

1078523

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

1078527

TP4AP
Short transient receptor potential channel 4-associated protein

2

0

High-throughput

0.602

High

1078521

RBBP6
E3 ubiquitin-protein ligase RBBP6

2

1

Small-scale

0.584

High

1078542

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

Small-scale

0.569

High

595928

HNF1A
Hepatocyte nuclear factor 1-alpha

1

9

Small-scale

0.561

High

622472

CCND1
G1/S-specific cyclin-D1

1

6

Small-scale

0.561

High

702491

C2TA
MHC class II transactivator

1

1

Small-scale

0.561

High

749530

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.561

High

1078517

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

9

Small-scale

0.542

High

1078546

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.537

High

1078533

SMRC1
SWI/SNF complex subunit SMARCC1

1

19

Small-scale

0.536

High

70765

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

1

High-throughput

0.536

High

486029

RAP2A
Ras-related protein Rap-2a

1

1

High-throughput

0.536

High

1078536

ANR27
Ankyrin repeat domain-containing protein 27

1

3

High-throughput

0.536

High

656118

PSB9
Proteasome subunit beta type-9

1

3

Small-scale

0.529

High

386807

P53
Cellular tumor antigen p53

1

8

Small-scale

0.527

High

515595

SRF
Serum response factor

1

5

Small-scale

0.527

High

595675

BCL3
B-cell lymphoma 3 protein

1

9

Small-scale

0.527

High

1075228

TEAD2
Transcriptional enhancer factor TEF-4

1

3

Small-scale

0.527

High

1078532

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.527

High

448669

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

1078551

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.513

High

1039592

SNW1
SNW domain-containing protein 1

1

0

Small-scale

0.505

High

1076243

TRIP4
Activating signal cointegrator 1

1

0

Small-scale

0.504

High

146228

ARI1A
AT-rich interactive domain-containing protein 1A

1

4

Small-scale

0.501

High

261520

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.501

High

588694

CR2
Complement receptor type 2

1

1

Small-scale

0.501

High

589872

TBP
TATA-box-binding protein

1

1

Small-scale

0.501

High

646922

1433T
14-3-3 protein theta

1

3

Small-scale

0.501

High

658509

TEAD1
Transcriptional enhancer factor TEF-1

1

3

Small-scale

0.501

High

1016187

FOXO1
Forkhead box protein O1

1

15

Small-scale

0.501

High

1078518

ANR11
Ankyrin repeat domain-containing protein 11

1

6

Small-scale

0.501

High

1078538

ANM1
Protein arginine N-methyltransferase 1

1

8

Small-scale

0.501

High

1039483

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

Small-scale

0.493

High

1078549

FOXA2
Hepatocyte nuclear factor 3-beta

1

6

Small-scale

0.481

High

959939

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

170379

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.479

High

197713

CRX
Cone-rod homeobox protein

1

11

High-throughput

0.479

High

274352

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

8

Small-scale

0.479

High

304179

UBR5
E3 ubiquitin-protein ligase UBR5

1

8

Small-scale

0.479

High

318627

EYA4
Eyes absent homolog 4

1

6

High-throughput

0.479

High

502142

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

505221

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

538724

HXB2
Homeobox protein Hox-B2

1

10

High-throughput

0.479

High

542016

ETS1
Protein C-ets-1

1

19

Small-scale

0.479

High

542745

ETS2
Protein C-ets-2

1

19

Small-scale

0.479

High

584971

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

Small-scale

0.479

High

786614

STA5A
Signal transducer and activator of transcription 5A

1

10

Small-scale

0.479

High

800390

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.479

High

831365

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.479

High

871580

HSP72
Heat shock-related 70 kDa protein 2

1

9

Small-scale

0.479

High

874974

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

932520

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

1

Small-scale

0.479

High

950192

SMAD3
Mothers against decapentaplegic homolog 3

1

9

Small-scale

0.479

High

980759

TLE3
Transducin-like enhancer protein 3

1

13

High-throughput

0.479

High

1075829

TRIPB
Thyroid receptor-interacting protein 11

1

12

Small-scale

0.479

High

1078514

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

Small-scale

0.479

High

1078520

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.479

High

1078525

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

Small-scale

0.479

High

1078526

SP7
Transcription factor Sp7

1

12

High-throughput

0.479

High

1078528

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

4

High-throughput

0.479

High

1078535

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.479

High

1078541

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1078544

SYTL2
Synaptotagmin-like protein 2

1

1

Small-scale

0.479

High

1078547

KLF15
Krueppel-like factor 15

1

10

High-throughput

0.479

High

1078552

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

Small-scale

0.479

High

940435

CXAR
Coxsackievirus and adenovirus receptor

1

0

Small-scale

0.460

High

1075659

SF01
Splicing factor 1

1

0

Small-scale

0.458

High

1078543

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.458

High

1078548

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.457

High

1078519

NBEL2
Neurobeachin-like protein 2

1

11

High-throughput

0.445

High

1078550

GRIP1
Glutamate receptor-interacting protein 1

1

0

Small-scale

0.438

High

420781

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.437

High

1078524

ZDH23
Palmitoyltransferase ZDHHC23

1

1

Small-scale

0.437

High

351793

CALC
Calcitonin [Cleaved into: Calcitonin; Katacalcin

1

1

High-throughput

0.407

High

180705

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.328

High

1012447

BRME1
Break repair meiotic recombinase recruitment factor 1

2

0

High-throughput

0.328

High

1078540

SPXN
Spexin

1

0

High-throughput

0.279

Low

1078545

ZDH18
Palmitoyltransferase ZDHHC18

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024