Protein: MBK2
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2 (EC 2.7.12.1) (Dual specificity Yak1-related kinase mbk-2) (Minibrain Kinase 2)

Gene: MBK2, mbk-2
Organism: Caenorhabditis elegans
Interactions: 125
UniProt ID: Q9XTF3

Gene Ontology (top 5):
GO:0000281 - mitotic cytokinesis
GO:0000793 - condensed chromosome
GO:0001556 - oocyte maturation
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

145631

CDC37
Probable Hsp90 co-chaperone cdc37

2

6

High-throughput

0.743

High

703908

CSK2B
Casein kinase II subunit beta

2

1

High-throughput

0.743

High

1169767

EGG3
Protein tyrosine phosphatase-like protein egg-3

4

5

Small-scale

0.701

High

145103

EGG4
Inactive protein-tyrosine phosphatase egg-4

3

4

Small-scale

0.677

High

110692

MOE1
CCCH-type zinc finger protein oma-1

3

6

Small-scale

0.655

High

1457622

Q9TXM1
Uncharacterized protein

3

2

Small-scale

0.646

High

111318

G5ED17
Protein kinase domain-containing protein

1

6

High-throughput

0.618

High

111814

G5EDL3
Aurora kinase

1

16

High-throughput

0.618

High

112228

G5EE09
poly(A)-specific ribonuclease

1

1

High-throughput

0.618

High

1427940

Q9GUP2
HECT-type E3 ubiquitin transferase

1

15

High-throughput

0.618

High

1457935

GSK3
Glycogen synthase kinase-3

1

19

High-throughput

0.618

High

760744

KTNA1
Meiotic spindle formation protein mei-1

2

13

Small-scale

0.585

High

759159

KLE2
Condensin-2 complex subunit kle-2

2

1

High-throughput

0.576

High

939165

SUMO
Small ubiquitin-related modifier

2

8

High-throughput

0.576

High

263865

EGG5
Inactive protein-tyrosine phosphatase egg-5

1

4

Small-scale

0.515

High

1170083

MEGG1
Protein meg-1

1

1

Small-scale

0.501

High

1171311

MOE2
CCCH-type zinc finger protein oma-2

1

4

Small-scale

0.501

High

1490293

MEX5
Zinc finger protein mex-5

1

4

Small-scale

0.501

High

84243

BRCA1
Breast cancer type 1 susceptibility protein homolog

1

11

High-throughput

0.479

High

98553

F1LIM5
ZZ-type domain-containing protein

1

4

High-throughput

0.479

High

110297

LE418
Protein let-418

1

3

High-throughput

0.479

High

111973

LIN35
Retinoblastoma-like protein homolog lin-35

1

15

High-throughput

0.479

High

111983

G5EDT9
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.479

High

112563

G5EEK5
Very Early Transcript

1

2

High-throughput

0.479

High

112909

G5EF11
E2F/DP family winged-helix DNA-binding domain-containing protein

1

11

High-throughput

0.479

High

113821

EGL18
Putative transcription factor egl-18

1

5

High-throughput

0.479

High

116626

H9G2X3
Serine/threonine protein phosphatase 2A regulatory subunit

1

1

High-throughput

0.479

High

144623

TMOD
Tropomodulin

1

4

High-throughput

0.479

High

144826

O01585
Rho-GAP domain-containing protein

1

8

High-throughput

0.479

High

195949

GLD2
Poly(A) RNA polymerase gld-2

1

3

High-throughput

0.479

High

196872

6PGL
Putative 6-phosphogluconolactonase

1

2

High-throughput

0.479

High

233697

O45080
One cut domain family member

1

15

High-throughput

0.479

High

262590

O61201
GATOR2 complex protein MIO zinc-ribbon like domain-containing protein

1

16

High-throughput

0.479

High

263857

O61770
CABIT domain-containing protein

1

1

High-throughput

0.479

High

263963

ERGO1
Piwi-like protein ergo-1

1

2

High-throughput

0.479

High

721192

LIN9
Protein lin-9

1

2

High-throughput

0.479

High

744456

CLAS2
Protein CLASP-2

1

3

High-throughput

0.479

High

759315

RFC5
Probable replication factor C subunit 5

1

2

High-throughput

0.479

High

857620

TCPZ
T-complex protein 1 subunit zeta

1

12

High-throughput

0.479

High

916479

RFC4
Replication factor C subunit 4

1

1

High-throughput

0.479

High

1067101

UBE4
Ubiquitin conjugation factor E4 ufd-2

1

7

High-throughput

0.479

High

1068086

GUAA
Probable GMP synthase [glutamine-hydrolyzing]

1

3

High-throughput

0.479

High

1068783

LIN23
F-box/WD repeat-containing protein lin-23

1

16

High-throughput

0.479

High

1083976

LIN13
Zinc finger protein lin-13

1

2

High-throughput

0.479

High

1164688

CNOT7
CCR4-NOT transcription complex subunit 7

1

4

High-throughput

0.479

High

1166189

IPYR
Inorganic pyrophosphatase 1

1

1

High-throughput

0.479

High

1166814

ZW10
Centromere/kinetochore protein zw10 homolog

1

1

High-throughput

0.479

High

1166836

HM38
Homeobox protein ceh-38

1

8

High-throughput

0.479

High

1169938

ATAD3
ATPase family AAA domain-containing protein 3

1

12

High-throughput

0.479

High

1170004

CNOT1
CCR4-NOT transcription complex subunit let-711

1

18

High-throughput

0.479

High

1170086

MEGG2
Protein meg-2

1

1

High-throughput

0.479

High

1170265

Q21501
YEATS domain-containing protein

1

7

High-throughput

0.479

High

1170758

Q22240
Ubiquitin carboxyl-terminal hydrolase 47

1

14

High-throughput

0.479

High

1170989

TFDP1
Transcription factor dpl-1

1

8

High-throughput

0.479

High

1171268

MRE11
Double-strand break repair protein mre-11

1

1

High-throughput

0.479

High

1176484

LI15B
Protein lin-15B

1

4

High-throughput

0.479

High

1201115

Q565A8
SUZ domain-containing protein

1

1

High-throughput

0.479

High

1261085

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

11

High-throughput

0.479

High

1302306

CASP
Protein CASP

1

19

High-throughput

0.479

High

1320885

Q8MPS6
Exportin-1 C-terminal domain-containing protein

1

5

High-throughput

0.479

High

1372557

Q93413
Helicase ATP-binding domain-containing protein

1

12

High-throughput

0.479

High

1372671

Q93934
Adenosine kinase

1

1

High-throughput

0.479

High

1378807

GLD3
Defective in germ line development protein 3

1

2

High-throughput

0.479

High

1428125

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

1444998

Q9N4A5
Phosphotransferase

1

1

High-throughput

0.479

High

1445052

Q9N533
WDR59/RTC1-like RING zinc finger domain-containing protein

1

14

High-throughput

0.479

High

1445347

SSL1
Helicase ssl-1

1

4

High-throughput

0.479

High

1457957

Q9U3F2
DNA replication ATP-dependent helicase/nuclease DNA2

1

8

High-throughput

0.479

High

1444985

Q9N415
Variant SH3 domain protein

1

5

High-throughput

0.464

High

109639

G5EBG0
HORMA domain-containing protein

1

0

High-throughput

0.458

High

110745

CHS1
Chitin synthase chs-1

1

0

High-throughput

0.458

High

195988

O17151
LIn-8 Domain containing

1

0

High-throughput

0.458

High

759323

YL57
Putative zinc finger protein F44E2.7

1

0

High-throughput

0.458

High

1084013

SOR3
Sop-2-related protein 3

1

0

High-throughput

0.458

High

1171011

TM201
Transmembrane protein 201 homolog

1

0

High-throughput

0.458

High

1171330

Q23406
Nanos-type domain-containing protein

1

0

High-throughput

0.458

High

1302674

Q8IG64
Piwi domain-containing protein

1

0

High-throughput

0.458

High

1372537

Q93321
Non-specific serine/threonine protein kinase

1

0

High-throughput

0.458

High

1378678

HYLS1
Centriolar and ciliogenesis-associated protein hyls-1

1

0

High-throughput

0.458

High

1445580

Q9NGT3
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.458

High

116241

H2L2C8
Alpha-actinin, sarcomeric

1

9

High-throughput

0.439

High

90949

C6KRI9
Kinesin motor domain-containing protein

1

20

High-throughput

0.437

High

113937

G5EGG0
Uso1_p115_head domain-containing protein

1

14

High-throughput

0.437

High

115591

H2KZQ8
Protein transport protein sec16

1

7

High-throughput

0.437

High

195456

O16393
BZIP domain-containing protein

1

3

High-throughput

0.437

High

196053

PLDL
Probable phospholipase D F09G2.8

1

2

High-throughput

0.437

High

759746

SOR1
Sop-2-related protein 1

1

1

High-throughput

0.437

High

759775

SC161
Protein transport protein sec-16A.1

1

8

High-throughput

0.437

High

1018922

P91176
CCHC-type domain-containing protein

1

6

High-throughput

0.437

High

1068165

PTC1
Protein patched homolog 1

1

3

High-throughput

0.437

High

1082605

Q10050
Mitochondrial ornithine transporter 1

1

8

High-throughput

0.437

High

1165044

Q17746
ZZ-type domain-containing protein

1

4

High-throughput

0.437

High

1165991

Q18403
WD_REPEATS_REGION domain-containing protein

1

13

High-throughput

0.437

High

1166774

Q19520
Minichromosome loss protein Mcl1 middle region domain-containing protein

1

12

High-throughput

0.437

High

1166992

STO2
Stomatin-2

1

6

High-throughput

0.437

High

1169713

HDA6
Histone deacetylase 6

1

7

High-throughput

0.437

High

1169970

P5CR4
Putative pyrroline-5-carboxylate reductase 4

1

1

High-throughput

0.437

High

1170112

Q21205
SAM domain-containing protein

1

1

High-throughput

0.437

High

1180997

Q304D5
Thioredoxin domain-containing protein

1

5

High-throughput

0.437

High

1204412

Q5FC73
Uncharacterized protein

1

3

High-throughput

0.437

High

1231305

NU301
Nucleosome-remodeling factor subunit NURF301-like

1

16

High-throughput

0.437

High

1372607

Q93641
Phosphatidylinositol-3-phosphatase SAC1

1

2

High-throughput

0.437

High

1374039

CLC91
C-type lectin domain-containing protein 91

1

1

High-throughput

0.437

High

1379773

SOP2
Polycomb protein sop-2

1

13

High-throughput

0.437

High

1457906

Q9U1Y6
Retinol dehydrogenase 13

1

1

High-throughput

0.437

High

1457923

Q9U2C2
Protein MCM10 homolog

1

1

High-throughput

0.437

High

1490295

Q9XVU8
Alpha-actinin, sarcomeric

1

7

High-throughput

0.417

High

1171430

HPO40
Hypersensitive to pore-forming toxin protein 40

1

0

High-throughput

0.251

Low

72251

A8XQE0
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.249

Low

109681

G5EBK0
DEP domain-containing protein

1

0

High-throughput

0.249

Low

115857

H2L0A8
RRM domain-containing protein

1

0

High-throughput

0.249

Low

145911

PRI2
DNA primase large subunit

1

0

High-throughput

0.249

Low

234140

O45656
snRNA-activating protein complex subunit 3

1

0

High-throughput

0.249

Low

264228

O62263
Protein SZT2

1

0

High-throughput

0.249

Low

758584

CIDS1
CID domain-containing protein 1

1

0

High-throughput

0.249

Low

759220

YLU3
Uncharacterized protein F10E9.3

1

0

High-throughput

0.249

Low

892823

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.249

Low

1019130

P91453
Uncharacterized protein

1

0

High-throughput

0.249

Low

1166106

Q18546
SAP domain-containing protein

1

0

High-throughput

0.249

Low

1169625

NPRL3
GATOR complex protein NPRL3

1

0

High-throughput

0.249

Low

1170485

Q21822
Intraflagellar transport protein 46 homolog

1

0

High-throughput

0.249

Low

1427967

Q9GYQ8
Sm domain-containing protein

1

0

High-throughput

0.249

Low

1457752

Q9TYM3
Protein aurora borealis

1

0

High-throughput

0.249

Low

1490294

Q9XUR4
F-box associated domain-containing protein

1

0

High-throughput

0.249

Low

1490296

Q9XX63
Coiled-coil domain-containing protein 69

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025