HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: MTMR6 (Q9Y217)
Myotubularin-related protein 6 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
Gene: MTMR6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0032587 - ruffle membrane GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1210 Hs			1 621
+	Hs
		1071029 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MTMR6_HUMAN (1-621): 0: 904: 100.00
+	Hs
		338827 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MTMR8_HUMAN (1-564): 0: 765: 59.23
+	Hs
		602030 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMR6_HUMAN (1-621): 0: 904: 100.00
+	Hs
		338864 EGFR_HUMAN (1-1210): 0: 1241: 100.00		MTMR9_HUMAN (2-547): 0: 664: 33.94
+	Hs
		1040904 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MTMR2_HUMAN (2-540): 0: 716: 37.75
+	Hs
		601971 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMR8_HUMAN (1-564): 0: 765: 59.23
+	Hs
		1071002 ERBB4_HUMAN (1-1199): 0: 1137: 49.46		MTMR9_HUMAN (2-547): 0: 664: 33.94
+	Hs
		601914 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMR1_HUMAN (2-541): 0: 719: 35.94
+	Hs
		601915 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMR2_HUMAN (2-540): 0: 716: 37.75
+	Hs
		601982 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMR9_HUMAN (2-547): 0: 664: 33.94
+	Hs
		602013 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		MTMRA_HUMAN (35-546): 2.22e-141: 431: 22.74
+	Hs
		59909 EPHA3_HUMAN (654-981): 7.78e-111: 372: 34.51		MTMRB_HUMAN (22-489): 4.2e-107: 340: 20.84