Protein: PDE12
2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)

Gene: PDE12
Organism: Homo sapiens
Interactions: 102
UniProt ID: Q6L8Q7

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000958 - mitochondrial mRNA catabolic process
GO:0004527 - exonuclease activity
GO:0004535 - poly(A)-specific ribonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508142

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

3

High-throughput

0.686

High

242004

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

1235918

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

1

High-throughput

0.611

High

279796

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

1162375

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

1235954

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

543221

UBL4A
Ubiquitin-like protein 4A

1

4

High-throughput

0.536

High

856740

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.536

High

1235924

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

786134

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

1113401

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1211290

DNLZ
DNL-type zinc finger protein

1

0

High-throughput

0.513

High

1235917

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1235921

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1235922

RT4I1
NAD(P)H oxidoreductase RTN4IP1, mitochondrial

1

0

High-throughput

0.513

High

1235936

SORT
Sortilin

1

0

High-throughput

0.513

High

1235938

DHRS4
Dehydrogenase/reductase SDR family member 4

1

0

High-throughput

0.513

High

1235930

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

1

High-throughput

0.489

High

1235956

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

66220

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

1

High-throughput

0.479

High

281982

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287312

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

345950

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

471086

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

519140

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.479

High

532673

CH60
60 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

828812

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

851922

EFTS
Elongation factor Ts, mitochondrial

1

1

High-throughput

0.479

High

856288

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

882727

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.479

High

1024079

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

1048562

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1058083

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

1

High-throughput

0.479

High

1067435

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

1083643

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1090436

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

1117759

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1123317

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.479

High

1142571

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

1207041

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1220568

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

1234414

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1235920

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1235925

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1235927

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

1235928

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1235933

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

1235940

TR61B
tRNA

1

1

High-throughput

0.479

High

1235943

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.479

High

1235944

IF3M
Translation initiation factor IF-3, mitochondrial

1

1

High-throughput

0.479

High

1235946

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1235949

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1235950

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1235952

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

1235953

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

1235955

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.479

High

1235957

ARI1
E3 ubiquitin-protein ligase ARIH1

1

1

High-throughput

0.479

High

1235958

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

61526

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

372303

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

412096

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

414029

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

529963

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

830921

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

986497

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1015526

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

1106581

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1106956

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1149581

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1235926

MCUR1
Mitochondrial calcium uniporter regulator 1

1

0

High-throughput

0.458

High

1235929

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1235935

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

1235937

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1235939

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1235941

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1235945

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1235947

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1235951

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1235960

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

295512

PSD10
26S proteasome non-ATPase regulatory subunit 10

1

2

High-throughput

0.445

High

1235931

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.445

High

588930

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

799212

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.437

High

1100014

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1138844

SYLM
Leucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1198573

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

1209271

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1235948

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1235959

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

913780

ZN131
Zinc finger protein 131

1

0

High-throughput

0.279

Low

1235934

INT14
Integrator complex subunit 14

1

0

High-throughput

0.279

Low

106113

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

227591

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

695718

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768434

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

965024

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1235915

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1235916

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1235923

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

1235919

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.232

Low

1235932

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low

1235942

SC11C
Signal peptidase complex catalytic subunit SEC11C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025