Protein: DDIT3
DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)

Gene: DDIT3
Organism: Homo sapiens
Interactions: 126
UniProt ID: P35638

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579173

ATF3
Cyclic AMP-dependent transcription factor ATF-3

10

16

Small-scale

0.759

High

727126

CEBPG
CCAAT/enhancer-binding protein gamma

7

16

Small-scale

0.751

High

569296

CEBPB
CCAAT/enhancer-binding protein beta

8

14

Small-scale

0.749

High

345356

FOS
Protein c-Fos

7

16

Small-scale

0.744

High

727195

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

6

14

High-throughput

0.735

High

548288

FOSL2
Fos-related antigen 2

5

14

High-throughput

0.725

High

727146

BATF
Basic leucine zipper transcriptional factor ATF-like

5

12

Small-scale

0.721

High

727121

CEBPA
CCAAT/enhancer-binding protein alpha

4

11

Small-scale

0.701

High

727186

DHB14
17-beta-hydroxysteroid dehydrogenase 14

5

0

High-throughput

0.697

High

727134

EP300
Histone acetyltransferase p300

4

2

Small-scale

0.690

High

579244

ATF4
Cyclic AMP-dependent transcription factor ATF-4

4

1

Small-scale

0.687

High

727158

EMSY
BRCA2-interacting transcriptional repressor EMSY

3

1

High-throughput

0.675

High

727144

CEBPE
CCAAT/enhancer-binding protein epsilon

3

14

Small-scale

0.661

High

727160

TEDC1
Tubulin epsilon and delta complex protein 1

3

0

Small-scale

0.646

High

727188

MCMBP
Mini-chromosome maintenance complex-binding protein

3

0

High-throughput

0.639

High

401528

JUN
Transcription factor Jun

2

12

Small-scale

0.629

High

727135

DBP
D site-binding protein

2

16

High-throughput

0.619

High

568248

ATF7
Cyclic AMP-dependent transcription factor ATF-7

2

6

High-throughput

0.619

High

60554

VP37C
Vacuolar protein sorting-associated protein 37C

3

1

High-throughput

0.616

High

727141

PCM1
Pericentriolar material 1 protein

2

0

High-throughput

0.612

High

727170

JDP2
Jun dimerization protein 2

2

14

High-throughput

0.606

High

727145

NF2L2
Nuclear factor erythroid 2-related factor 2

1

8

Small-scale

0.603

High

157181

BACH1
Transcription regulator protein BACH1

2

2

High-throughput

0.602

High

216681

CREB3
Cyclic AMP-responsive element-binding protein 3

2

3

High-throughput

0.602

High

547733

ATF2
Cyclic AMP-dependent transcription factor ATF-2

2

6

High-throughput

0.602

High

566730

JUNB
Transcription factor JunB

2

6

High-throughput

0.602

High

727147

HLF
Hepatic leukemia factor

2

16

High-throughput

0.602

High

727149

NFIL3
Nuclear factor interleukin-3-regulated protein

2

12

High-throughput

0.602

High

727181

TRIB3
Tribbles homolog 3

2

0

Small-scale

0.598

High

206557

TNF12
Tumor necrosis factor ligand superfamily member 12

3

1

High-throughput

0.597

High

727122

CEBPD
CCAAT/enhancer-binding protein delta

2

16

Small-scale

0.595

High

214120

SPOP
Speckle-type POZ protein

2

0

Small-scale

0.588

High

727138

HDAC1
Histone deacetylase 1

2

1

Small-scale

0.584

High

236475

CRBL2
cAMP-responsive element-binding protein-like 2

2

0

High-throughput

0.580

High

727163

TXND2
Thioredoxin domain-containing protein 2

2

0

High-throughput

0.580

High

727168

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

727183

THIOM
Thioredoxin, mitochondrial

2

0

High-throughput

0.580

High

727187

EFC4B
EF-hand calcium-binding domain-containing protein 4B

2

0

High-throughput

0.580

High

568069

JUND
Transcription factor JunD

1

5

Small-scale

0.573

High

727120

DDIT3
DNA damage-inducible transcript 3 protein

2

0

High-throughput

0.560

High

277381

GABR2
Gamma-aminobutyric acid type B receptor subunit 2

1

1

Small-scale

0.552

High

280097

SNPC5
snRNA-activating protein complex subunit 5

1

0

High-throughput

0.549

High

622097

ZBT25
Zinc finger and BTB domain-containing protein 25

1

0

High-throughput

0.549

High

638235

RBTN2
Rhombotin-2

1

0

High-throughput

0.549

High

727156

ZC3HE
Zinc finger CCCH domain-containing protein 14

1

0

High-throughput

0.549

High

727165

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.549

High

727203

AMOL2
Angiomotin-like protein 2

1

0

High-throughput

0.549

High

727130

CDK6
Cyclin-dependent kinase 6

1

0

Small-scale

0.545

High

727127

RS3A
Small ribosomal subunit protein eS1

1

0

Small-scale

0.537

High

727142

MTFR1
Mitochondrial fission regulator 1

1

1

High-throughput

0.536

High

727162

TLK2
Serine/threonine-protein kinase tousled-like 2

1

1

High-throughput

0.536

High

727192

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

1

High-throughput

0.536

High

727200

TLK1
Serine/threonine-protein kinase tousled-like 1

1

1

High-throughput

0.536

High

616150

RS3
Small ribosomal subunit protein uS3

1

0

Small-scale

0.529

High

341139

THRB
Prothrombin

1

0

High-throughput

0.518

High

595585

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.518

High

727159

RAI1
Retinoic acid-induced protein 1

1

0

High-throughput

0.518

High

727180

ZSC31
Zinc finger and SCAN domain-containing protein 31

1

0

High-throughput

0.518

High

727185

SSX3
Protein SSX3

1

0

High-throughput

0.518

High

727205

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.518

High

727128

CSK21
Casein kinase II subunit alpha

1

0

Small-scale

0.513

High

161320

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

727133

HSF2
Heat shock factor protein 2

1

0

High-throughput

0.513

High

727204

RBGP1
Rab GTPase-activating protein 1

1

0

High-throughput

0.513

High

181919

MAFG
Transcription factor MafG

1

1

High-throughput

0.501

High

548230

FOSL1
Fos-related antigen 1

1

13

High-throughput

0.501

High

727164

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

2

High-throughput

0.501

High

727178

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

7

High-throughput

0.501

High

727189

BACH2
Transcription regulator protein BACH2

1

2

High-throughput

0.501

High

727201

MAFF
Transcription factor MafF

1

1

High-throughput

0.501

High

535338

GFAP
Glial fibrillary acidic protein

1

0

High-throughput

0.493

High

727154

MTFR2
Mitochondrial fission regulator 2

1

1

High-throughput

0.489

High

158162

GIPC1
PDZ domain-containing protein GIPC1

1

0

Small-scale

0.486

High

727148

MK14
Mitogen-activated protein kinase 14

1

0

Small-scale

0.480

High

727184

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.480

High

727191

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

727199

DNM3L
DNA

1

0

Small-scale

0.480

High

146166

ARI1A
AT-rich interactive domain-containing protein 1A

1

1

Small-scale

0.479

High

726620

FUS
RNA-binding protein FUS

1

2

Small-scale

0.479

High

727123

SMCA2
Probable global transcription activator SNF2L2

1

1

Small-scale

0.479

High

727124

SMCA4
Transcription activator BRG1

1

1

Small-scale

0.479

High

727132

EWS
RNA-binding protein EWS

1

2

Small-scale

0.479

High

727139

CUL1
Cullin-1

1

1

Small-scale

0.479

High

727140

CUL3
Cullin-3

1

1

Small-scale

0.479

High

727143

SSXT
Protein SSXT

1

2

Small-scale

0.479

High

727152

ARID2
AT-rich interactive domain-containing protein 2

1

1

Small-scale

0.479

High

727157

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

2

Small-scale

0.479

High

727161

PB1
Protein polybromo-1

1

2

Small-scale

0.479

High

727166

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

Small-scale

0.479

High

727167

SMRC2
SWI/SNF complex subunit SMARCC2

1

1

Small-scale

0.479

High

727171

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.479

High

727172

REQU
Zinc finger protein ubi-d4

1

1

Small-scale

0.479

High

727173

CBP
CREB-binding protein

1

2

Small-scale

0.479

High

727174

RBP56
TATA-binding protein-associated factor 2N

1

2

Small-scale

0.479

High

727175

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

Small-scale

0.479

High

727176

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

2

Small-scale

0.479

High

727179

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.479

High

727196

HDAC6
Histone deacetylase 6

1

2

Small-scale

0.479

High

727197

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.479

High

727202

HDAC5
Histone deacetylase 5

1

2

Small-scale

0.479

High

727151

Q4ACW9
HCG1991317, isoform CRA_b

1

1

High-throughput

0.470

High

427769

GP1BA
Platelet glycoprotein Ib alpha chain

1

0

High-throughput

0.460

High

727125

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

727155

GIMA6
GTPase IMAP family member 6

1

0

High-throughput

0.460

High

176565

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.458

High

275380

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

Small-scale

0.458

High

308456

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

331451

ACL6A
Actin-like protein 6A

1

0

Small-scale

0.458

High

414194

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

501760

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

614260

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

0

Small-scale

0.458

High

727131

E2F1
Transcription factor E2F1

1

0

Small-scale

0.458

High

727136

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

727137

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

Small-scale

0.458

High

727177

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

Small-scale

0.458

High

727182

CSN8
COP9 signalosome complex subunit 8

1

0

Small-scale

0.458

High

727190

ATG5
Autophagy protein 5

1

0

Small-scale

0.458

High

727193

MLXPL
Carbohydrate-responsive element-binding protein

1

0

Small-scale

0.458

High

727194

IL23A
Interleukin-23 subunit alpha

1

0

Small-scale

0.458

High

727198

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

484432

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.438

High

727153

RTL6
Retrotransposon Gag-like protein 6

2

0

High-throughput

0.328

High

727150

DRC12
Dynein regulatory complex protein 12

1

0

High-throughput

0.299

High

727129

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.282

High

727169

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low


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Last updated: 15 Jul 2024