HitPredict

Interactor 1: EGFR (P00533)
Epidermal growth factor receptor (EC 2.7.10.1) (Proto-oncogene c-ErbB-1) (Receptor tyrosine-protein kinase erbB-1)
Gene: EGFR

Interactor 2: DJC16 (Q9Y2G8)
DnaJ homolog subfamily C member 16 (Endoplasmic reticulum DNA J domain-containing protein 8) (ER-resident protein ERdj8) (ERdj8)
Gene: DNAJC16

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	25754235, 35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1210 Hs			1 782
+	Hs
		243241 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA2_HUMAN (27-374): 2.08e-45: 170: 18.01
+	Hs
		339080 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJB11_HUMAN (7-232): 6.1e-36: 141: 26.38
+	Hs
		338003 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA1_HUMAN (26-213): 4.7e-35: 139: 26.98
+	Hs
		339049 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJB12_HUMAN (28-160): 6.64e-35: 138: 32.33
+	Hs
		338830 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DNJA3_HUMAN (29-106): 3.89e-19: 93.2: 54.43
+	Hs
		338707 EGFR_HUMAN (1-1210): 0: 1241: 100.00		TXND5_HUMAN (151-250): 1.1e-14: 79.2: 25.24
+	Hs
		337778 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PDIA1_HUMAN (80-244): 3.2e-12: 71.9: 14.79
+	Hs
		337993 EGFR_HUMAN (1-1210): 0: 1241: 100.00		PDIA3_HUMAN (103-251): 1.3e-11: 70: 13.07
+	Hs
		338668 EGFR_HUMAN (1-1210): 0: 1241: 100.00		DJC10_HUMAN (56-248): 2.28e-11: 69.6: 12.00
+	Hs
		243250 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA2_HUMAN (27-374): 2.08e-45: 170: 18.01
+	Hs
		384016 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DJB11_HUMAN (7-232): 6.1e-36: 141: 26.38
+	Hs
		383639 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA1_HUMAN (26-213): 4.7e-35: 139: 26.98
+	Hs
		384003 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DJB12_HUMAN (28-160): 6.64e-35: 138: 32.33
+	Hs
		602017 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DJB11_HUMAN (7-232): 6.1e-36: 141: 26.38
+	Hs
		601821 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		DNJA1_HUMAN (26-213): 4.7e-35: 139: 26.98
+	Hs
		383929 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DNJA3_HUMAN (29-106): 3.89e-19: 93.2: 54.43
+	Hs
		383876 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		DJC10_HUMAN (56-248): 2.28e-11: 69.6: 12.00
+	Hs
		383571 ERBB2_HUMAN (5-1200): 0: 1111: 48.49		PDIA4_HUMAN (121-245): 6.82e-10: 64.6: 16.92
+	Hs
		531718 ERBB3_HUMAN (1-1210): 0: 1080: 40.95		PDIA4_HUMAN (121-245): 6.82e-10: 64.6: 16.92
+	Hs
		243261 RET_HUMAN (420-1058): 5.61e-129: 425: 22.69		DNJA2_HUMAN (27-374): 2.08e-45: 170: 18.01