Protein: TM109
Voltage-gated monoatomic cation channel TMEM109 (Mitsugumin-23) (Mg23) (Transmembrane protein 109)

Gene: TM109, TMEM109
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q9BVC6

Gene Ontology (top 5):
GO:0005640 - nuclear outer membrane
GO:0022843 - voltage-gated monoatomic cation channel activity
GO:0033017 - sarcoplasmic reticulum membrane
GO:0034702 - monoatomic ion channel complex
GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

199474

SPIT1
Kunitz-type protease inhibitor 1

2

1

High-throughput

0.606

High

646283

STOM
Stomatin

2

1

High-throughput

0.606

High

781300

AQP2
Aquaporin-2

2

0

High-throughput

0.580

High

1024650

PDZ1I
PDZK1-interacting protein 1

2

0

High-throughput

0.580

High

1117395

TM52B
Transmembrane protein 52B

2

0

High-throughput

0.580

High

201102

AQP9
Aquaporin-9

2

1

High-throughput

0.553

High

1293486

TMM80
Transmembrane protein 80

2

1

High-throughput

0.553

High

1313745

SAR1A
Small COPII coat GTPase SAR1A

2

1

High-throughput

0.553

High

395649

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.536

High

360360

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

1

High-throughput

0.535

High

359065

CRYAB
Alpha-crystallin B chain

1

0

Small-scale

0.529

High

895248

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.513

High

348899

RASN
GTPase NRas

1

2

High-throughput

0.479

High

436487

RHOC
Rho-related GTP-binding protein RhoC

1

5

High-throughput

0.479

High

545589

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

719105

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

894376

CDC42
Cell division control protein 42 homolog

1

5

High-throughput

0.479

High

900854

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

925577

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

951284

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

163963

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

632385

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

670186

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

808893

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

839101

EMD
Emerin

1

0

High-throughput

0.458

High

844711

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.458

High

917857

H4
Histone H4

1

0

High-throughput

0.458

High

1043553

CUL4B
Cullin-4B

1

0

High-throughput

0.458

High

1312223

H2AJ
Histone H2A.J

1

0

High-throughput

0.458

High

1313736

TM109
Voltage-gated monoatomic cation channel TMEM109

1

0

High-throughput

0.458

High

120615

RHOD
Rho-related GTP-binding protein RhoD

1

6

High-throughput

0.437

High

350503

RASK
GTPase KRas

1

2

High-throughput

0.437

High

595386

LMNB1
Lamin-B1

1

1

High-throughput

0.437

High

1156698

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1198672

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

High-throughput

0.437

High

1204827

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

1240754

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

1292855

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1313741

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

1313750

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

887947

CD81
CD81 antigen

1

0

High-throughput

0.426

High

883633

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

157648

MGST3
Glutathione S-transferase 3, mitochondrial

2

0

High-throughput

0.316

High

985383

VMAT2
Synaptic vesicular amine transporter

2

0

High-throughput

0.316

High

1239855

GOLM1
Golgi membrane protein 1

2

0

High-throughput

0.316

High

1256180

GPX8
Probable glutathione peroxidase 8

2

0

High-throughput

0.316

High

1295769

RN170
E3 ubiquitin-protein ligase RNF170

2

0

High-throughput

0.316

High

1313740

IF3M
Translation initiation factor IF-3, mitochondrial

2

0

High-throughput

0.316

High

1313753

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

2

0

High-throughput

0.316

High

390496

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.305

High

678059

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

739578

DHB2
17-beta-hydroxysteroid dehydrogenase type 2

1

0

High-throughput

0.279

Low

1132964

CSCL2
CSC1-like protein 2

1

0

High-throughput

0.279

Low

1150163

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1156889

NIPA3
Magnesium transporter NIPA3

1

0

High-throughput

0.279

Low

1233944

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

1283262

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.279

Low

1312347

TMM43
Transmembrane protein 43

1

0

High-throughput

0.279

Low

1313738

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1313747

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.279

Low

1313755

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

170940

PGRC2
Membrane-associated progesterone receptor component 2

1

0

High-throughput

0.269

Low

122974

MEN1
Menin

1

0

High-throughput

0.249

Low

127664

CCRL2
C-C chemokine receptor-like 2

1

0

High-throughput

0.249

Low

160752

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

205918

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

325876

LATS1
Serine/threonine-protein kinase LATS1

1

0

High-throughput

0.249

Low

391146

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

508175

FGFR1
Fibroblast growth factor receptor 1

1

0

Small-scale

0.249

Low

553603

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

596019

EFNA1
Ephrin-A1

1

0

High-throughput

0.249

Low

652134

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721327

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

780028

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

795259

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

818415

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

832689

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

847638

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.249

Low

890388

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.249

Low

941383

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

965822

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

1016856

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1018924

SEPR
Prolyl endopeptidase FAP

1

0

Small-scale

0.249

Low

1080292

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1165917

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1171518

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1200864

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.249

Low

1230354

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1240283

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1243912

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

1256369

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

1269506

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1281146

KISSR
KiSS-1 receptor

1

0

Small-scale

0.249

Low

1302820

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

1303542

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1313038

DERL1
Derlin-1

1

0

High-throughput

0.249

Low

1313737

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.249

Low

1313739

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

1313742

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1313743

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1313744

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

0

High-throughput

0.249

Low

1313746

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1313748

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

1313749

GDE1
Glycerophosphodiester phosphodiesterase 1

1

0

High-throughput

0.249

Low

1313751

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

1313752

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.249

Low

1313756

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

1313757

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.249

Low

216824

CREB3
Cyclic AMP-responsive element-binding protein 3

1

0

High-throughput

0.238

Low

63542

T238L
Transmembrane protein 238-like

1

0

Small-scale

0.232

Low

402423

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1313754

SHLB1
Endophilin-B1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024