HitPredict

Interactor 1: VATG2 (O95670)
V-type proton ATPase subunit G 2 (V-ATPase subunit G 2) (V-ATPase 13 kDa subunit 2) (Vacuolar proton pump subunit G 2)
Gene: ATP6V1G2

Interactor 2: VATE2 (Q96A05)
V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
Gene: ATP6V1E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	32296183, 33961781, unassigned1304, unassigned3799
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, two hybrid prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	V-ATPase_G~vATP-synt_E
Common GO terms	GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 118 Hs			1 226
+	Hs
		276819 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VATE1_HUMAN (1-225): 3.67e-98: 286: 76.89
+	Hs
		341198 VATG2_HUMAN (1-118): 1.32e-30: 107: 100.00		VATE1_HUMAN (1-225): 3.67e-98: 286: 76.89
+	Dm
		930277 VATG_DROME (1-114): 1.72e-30: 106: 49.12		VATE_DROME (1-224): 4.62e-94: 276: 61.16
+	Ce
		1018978 VATG_CAEEL (1-113): 2.92e-26: 96.4: 50.44		VATE_CAEEL (1-225): 1.26e-96: 282: 56.00
+	Hs
		276852 VATG1_HUMAN (1-118): 1.67e-31: 109: 63.56		VATE2_HUMAN (1-226): 5.43e-90: 266: 100.00
+	Sc
		645844 VATG_YEAST (3-113): 3.07e-23: 88.3: 32.43		VATE_YEAST (2-225): 2.39e-76: 231: 35.40