HitPredict

Interactor 1: VATE (P54611)
V-type proton ATPase subunit E (V-ATPase subunit E) (V-ATPase 26 kDa subunit) (Vacuolar proton pump subunit E)
Gene: Vha26

Interactor 2: VATG (Q9XZH6)
V-type proton ATPase subunit G (V-ATPase subunit G) (V-ATPase 13 kDa subunit) (Vacuolar proton pump subunit G)
Gene: Vha13

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	14605208, 37061542, unassigned2874, 38944040
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	V-ATPase_G~vATP-synt_E
Common GO terms	GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0007430 - terminal branching, open tracheal system GO:0033181 - plasma membrane proton-transporting V-type ATPase complex GO:0035002 - liquid clearance, open tracheal system GO:0046961 - proton-transporting ATPase activity, rotational mechanism and 1 others more... GO:1902600 - proton transmembrane transport
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 226 Dm			1 117
+	Hs
		276819 VATE1_HUMAN (1-226): 3.27e-100: 291: 63.27		VATG1_HUMAN (1-114): 5.63e-30: 105: 50.00
+	Hs
		341198 VATE1_HUMAN (1-226): 3.27e-100: 291: 63.27		VATG2_HUMAN (1-114): 9e-28: 99.8: 49.12
+	Ce
		1018978 VATE_CAEEL (1-226): 1.66e-98: 287: 58.85		VATG_CAEEL (1-113): 3.88e-26: 96: 52.21
+	Hs
		276852 VATE2_HUMAN (1-225): 7.17e-90: 265: 60.89		VATG1_HUMAN (1-114): 5.63e-30: 105: 50.00
+	Hs
		341218 VATE2_HUMAN (1-225): 7.17e-90: 265: 60.89		VATG2_HUMAN (1-114): 9e-28: 99.8: 49.12
+	Sc
		645844 VATE_YEAST (2-226): 4.01e-76: 230: 34.36		VATG_YEAST (3-113): 7.1e-23: 87.5: 36.94