HitPredict

Interactor 1: HERC2 (O95714)
E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)
Gene: HERC2

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29511261
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 4834 Hs			1 494
+	Hs
		342729 HERC2_HUMAN (1-4834): 0: 6292: 100.00		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		342852 HERC2_HUMAN (1-4834): 0: 6292: 100.00		PABP4_HUMAN (101-185): 3.05e-11: 67.7: 20.00
+	Hs
		131986 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Hs
		1061140 WWP1_HUMAN (4321-4794): 1.79e-168: 549: 21.37		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Hs
		132006 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50
+	Hs
		132005 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1099245 WWP1_HUMAN (4321-4794): 1.79e-168: 549: 21.37		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1061163 SMUF1_HUMAN (4280-4794): 2.43e-160: 519: 19.71		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Dm
		1485023 SUDX_DROME (4313-4791): 3.09e-165: 540: 19.64		Q9VRM6_DROME (157-484): 6.16e-44: 168: 26.02
+	Hs
		550415 ITCH_HUMAN (4309-4794): 4.12e-172: 559: 22.02		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		131699 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		PABP1_HUMAN (1-189): 3.74e-31: 128: 19.50
+	Hs
		132010 WWP2_HUMAN (4317-4794): 5.4e-171: 554: 19.46		PABP4_HUMAN (101-185): 3.05e-11: 67.7: 20.00
+	Hs
		1061040 HUWE1_HUMAN (4365-4788): 3.25e-118: 426: 24.00		SRSF1_HUMAN (3-166): 2.37e-57: 192: 41.42
+	Hs
		1099141 HUWE1_HUMAN (4365-4788): 3.25e-118: 426: 24.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		1099592 HERC5_HUMAN (424-597): 6.75e-11: 71.2: 26.56		SRSF6_HUMAN (1-180): 4.54e-52: 181: 78.50
+	Hs
		1409872 HERC5_HUMAN (424-597): 6.75e-11: 71.2: 26.56		RBM4B_HUMAN (3-104): 4.7e-11: 66.1: 23.08