Interactor 1: ANGT (P01019)
Angiotensinogen (Serpin A8) [Cleaved into: Angiotensin-1 (Angiotensin 1-10) (Angiotensin I) (Ang I); Angiotensin-2 (Angiotensin 1-8) (Angiotensin II) (Ang II); Angiotensin-3 (Angiotensin 2-8) (Angiotensin III) (Ang III) (Des-Asp[1]-angiotensin II); Angiotensin-4 (Angiotensin 3-8) (Angiotensin IV) (Ang IV); Angiotensin 1-9; Angiotensin 1-7; Angiotensin 1-5; Angiotensin 1-4]
Gene: AGT

Interactor 2: ACE (P12821)
Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form]
Gene: ACE

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 10969042, 15283675, 23056909
Identification Methods enzymatic study, x-ray crystallography
Interaction Type direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001822 - kidney development
GO:0001974 - blood vessel remodeling
GO:0002019 - regulation of renal output by angiotensin
GO:0005576 - extracellular region
GO:0005615 - extracellular space
and 5 others

more...

Homologous interactions 4

Homologous interactions

Color coding for hit scores

1 476
Hs

1 1306
+ Hs
+ Ss
+ Hs
+ Hs

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Last updated: 15 Jul 2024