Protein: PTBP2
Polypyrimidine tract-binding protein 2 (Neural polypyrimidine tract-binding protein) (Neurally-enriched homolog of PTB) (PTB-like protein)

Gene: PTBP2
Organism: Homo sapiens
Interactions: 66
UniProt ID: Q9UKA9

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005681 - spliceosomal complex
GO:0006376 - mRNA splice site recognition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

687536

PTBP1
Polypyrimidine tract-binding protein 1

6

15

High-throughput

0.930

High

1023194

RBM10
RNA-binding protein 10

4

17

High-throughput

0.899

High

478250

SNRPA
U1 small nuclear ribonucleoprotein A

4

19

High-throughput

0.890

High

1253992

RBPS2
RNA-binding protein with multiple splicing 2

2

2

High-throughput

0.783

High

775364

FUS
RNA-binding protein FUS

2

19

Small-scale

0.776

High

1152670

ELAV1
ELAV-like protein 1

2

19

High-throughput

0.775

High

344361

PTBP3
Polypyrimidine tract-binding protein 3

2

15

High-throughput

0.737

High

1460994

PTBP2
Polypyrimidine tract-binding protein 2

1

15

High-throughput

0.698

High

1101087

G3BP1
Ras GTPase-activating protein-binding protein 1

1

18

High-throughput

0.691

High

1116116

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.691

High

846520

MATR3
Matrin-3

4

17

High-throughput

0.690

High

462700

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

20

High-throughput

0.656

High

1120382

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.656

High

1406873

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

20

High-throughput

0.656

High

1416142

RBM4
RNA-binding protein 4

1

20

High-throughput

0.656

High

1460123

PUF60
Poly(U)-binding-splicing factor PUF60

1

19

High-throughput

0.656

High

961120

MGN
Protein mago nashi homolog

1

2

High-throughput

0.621

High

1006784

SRPK2
SRSF protein kinase 2

1

12

High-throughput

0.621

High

1400096

QKI
KH domain-containing RNA-binding protein QKI

2

11

High-throughput

0.620

High

485498

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

20

High-throughput

0.618

High

615604

NELFE
Negative elongation factor E

1

2

High-throughput

0.618

High

1369866

CELF1
CUGBP Elav-like family member 1

1

20

High-throughput

0.618

High

1453310

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

20

Small-scale

0.575

High

430489

JUN
Transcription factor Jun

2

6

High-throughput

0.571

High

944867

PCBP3
Poly(rC)-binding protein 3

1

20

High-throughput

0.541

High

1095843

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

5

High-throughput

0.541

High

530545

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.536

High

765981

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.536

High

1404489

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

1428956

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.518

High

284725

KHDR3
KH domain-containing, RNA-binding, signal transduction-associated protein 3

1

11

High-throughput

0.508

High

1059993

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

11

High-throughput

0.508

High

186111

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

1370869

FUBP2
Far upstream element-binding protein 2

1

20

Small-scale

0.501

High

1090971

TRAF2
TNF receptor-associated factor 2

1

13

High-throughput

0.489

High

1339755

TNIP2
TNFAIP3-interacting protein 2

1

2

High-throughput

0.489

High

1147016

PCBP2
Poly(rC)-binding protein 2

1

20

High-throughput

0.481

High

1460995

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

1

High-throughput

0.481

High

143316

NFIB
Nuclear factor 1 B-type

1

12

High-throughput

0.479

High

243251

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

331400

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

589995

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

696822

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

731689

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

766930

PHB1
Prohibitin 1

1

4

High-throughput

0.479

High

872868

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

905269

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

998930

H31
Histone H3.1

1

3

High-throughput

0.479

High

1067820

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1313515

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1387626

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

13

High-throughput

0.479

High

1446429

BRD7
Bromodomain-containing protein 7

1

8

High-throughput

0.479

High

1448782

RNC
Ribonuclease 3

1

5

High-throughput

0.479

High

1453035

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1279796

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

2

High-throughput

0.470

High

1063689

GOGA2
Golgin subfamily A member 2

1

9

High-throughput

0.464

High

1097078

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.460

High

1130513

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

769475

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

1227673

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.437

High

1415904

DDA1
DET1- and DDB1-associated protein 1

1

1

High-throughput

0.437

High

838198

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

1119352

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

13

High-throughput

0.407

High

256512

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.282

High

1416053

CC106
Coiled-coil domain-containing protein 106

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025