HitPredict

Interactor 1: CO3 (P01024)
Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
Gene: C3

Interactor 2: FHR3 (Q02985)
Complement factor H-related protein 3 (FHR-3) (DOWN16) (H factor-like protein 3)
Gene: CFHR3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10622723
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	A2M~Sushi, A2M_BRD~Sushi, MG1~Sushi, MG2~Sushi, MG4~Sushi, NTR~Sushi, Sushi~TED_complement
Common GO terms	GO:0005615 - extracellular space GO:0006956 - complement activation GO:0070062 - extracellular exosome GO:0072562 - blood microparticle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1663 Hs			1 330
+	Hs
		344663 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR1_HUMAN (1-329): 1.19e-89: 273: 40.30
+	Hs
		344649 CO3_HUMAN (1-1663): 0: 2219: 100.00		MASP1_HUMAN (37-294): 9.3e-47: 169: 17.46
+	Hs
		119680 CO3_HUMAN (1-1663): 0: 2219: 100.00		MASP2_HUMAN (36-298): 6.23e-43: 158: 14.11
+	Hs
		344619 CO3_HUMAN (1-1663): 0: 2219: 100.00		F13B_HUMAN (5-329): 1.47e-39: 149: 24.06
+	Hs
		344697 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR4_HUMAN (2-265): 1.79e-29: 120: 23.81
+	Hs
		344636 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR1_HUMAN (13-208): 1.11e-18: 89.1: 21.70
+	Hs
		344624 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAH_HUMAN (5-206): 1.43e-18: 88.7: 18.10
+	Hs
		344710 CO3_HUMAN (1-1663): 0: 2219: 100.00		FHR5_HUMAN (151-330): 4.94e-18: 86.8: 21.51
+	Hs
		341566 CO3_HUMAN (1-1663): 0: 2219: 100.00		CFAB_HUMAN (6-164): 1.59e-16: 82.5: 15.61
+	Hs
		344632 CO3_HUMAN (1-1663): 0: 2219: 100.00		MCP_HUMAN (12-154): 9.13e-11: 64.4: 18.95
+	Hs
		344638 CO3_HUMAN (1-1663): 0: 2219: 100.00		CR2_HUMAN (8-145): 1.44e-10: 64.4: 17.12
+	Mm
		344735 CO3_MOUSE (1-1663): 0: 2139: 76.77		CFAH_MOUSE (204-330): 4.68e-10: 62.9: 20.46
+	Hs
		344753 CO5_HUMAN (10-1661): 0: 1664: 27.73		CO6_HUMAN (22-263): 1.28e-37: 144: 16.80
+	Hs
		469901 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MASP1_HUMAN (37-294): 9.3e-47: 169: 17.46
+	Hs
		455003 CO4B_HUMAN (16-1661): 0: 1625: 28.37		C1S_HUMAN (33-295): 1.6e-44: 163: 16.77
+	Hs
		119684 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MASP2_HUMAN (36-298): 6.23e-43: 158: 14.11
+	Hs
		119683 CO4A_HUMAN (16-1661): 0: 1624: 28.20		MASP2_HUMAN (36-298): 6.23e-43: 158: 14.11
+	Hs
		469908 CO4B_HUMAN (16-1661): 0: 1625: 28.37		FHR4_HUMAN (2-265): 1.79e-29: 120: 23.81
+	Hs
		416130 CO4B_HUMAN (16-1661): 0: 1625: 28.37		CO2_HUMAN (18-154): 4.26e-13: 72.1: 18.18
+	Hs
		469899 CO4B_HUMAN (16-1661): 0: 1625: 28.37		MCP_HUMAN (12-154): 9.13e-11: 64.4: 18.95