Protein: AP3D1
AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)

Gene: AP3D1
Organism: Homo sapiens
Interactions: 174
UniProt ID: O14617

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005794 - Golgi apparatus
GO:0006623 - protein targeting to vacuole

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

158862

AP3S1
AP-3 complex subunit sigma-1

8

20

Small-scale

0.966

High

158902

AP3M1
AP-3 complex subunit mu-1

5

20

Small-scale

0.919

High

158798

AP3M2
AP-3 complex subunit mu-2

2

20

High-throughput

0.811

High

158795

VAMP7
Vesicle-associated membrane protein 7

2

4

Small-scale

0.793

High

158800

AP3S2
AP-3 complex subunit sigma-2

2

20

Small-scale

0.783

High

126022

AP3B1
AP-3 complex subunit beta-1

2

16

Small-scale

0.768

High

158736

RNF13
E3 ubiquitin-protein ligase RNF13

5

11

Small-scale

0.721

High

158866

DTBP1
Dysbindin

4

2

High-throughput

0.691

High

158887

AGO3
Protein argonaute-3

3

3

High-throughput

0.667

High

158744

TM63A
Mechanosensitive cation channel TMEM63A

3

1

High-throughput

0.662

High

158856

TPC2
Two pore channel protein 2

2

1

High-throughput

0.628

High

158900

E41L3
Band 4.1-like protein 3

2

7

High-throughput

0.628

High

158772

ARF4
ADP-ribosylation factor 4

1

20

High-throughput

0.618

High

158802

ARF3
ADP-ribosylation factor 3

1

20

High-throughput

0.618

High

158805

ARF6
ADP-ribosylation factor 6

1

20

High-throughput

0.618

High

158808

ARF1
ADP-ribosylation factor 1

1

20

High-throughput

0.618

High

158809

ARF5
ADP-ribosylation factor 5

1

20

High-throughput

0.618

High

158819

AP3B2
AP-3 complex subunit beta-2

1

16

Small-scale

0.618

High

158882

DNJC5
DnaJ homolog subfamily C member 5

2

3

High-throughput

0.611

High

158820

VPP3
V-type proton ATPase 116 kDa subunit a 3

2

2

High-throughput

0.601

High

158854

CAMKV
CaM kinase-like vesicle-associated protein

2

3

High-throughput

0.601

High

158738

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.584

High

158752

MYC
Myc proto-oncogene protein

2

8

High-throughput

0.584

High

158793

BAP31
B-cell receptor-associated protein 31

2

2

High-throughput

0.584

High

158853

SIDT2
SID1 transmembrane family member 2

2

0

High-throughput

0.576

High

158765

HSP7C
Heat shock cognate 71 kDa protein

2

6

High-throughput

0.571

High

158845

S15A3
Solute carrier family 15 member 3

2

8

High-throughput

0.571

High

158873

RUFY1
RUN and FYVE domain-containing protein 1

2

17

Small-scale

0.570

High

158858

ZCH10
Zinc finger CCHC domain-containing protein 10

2

3

High-throughput

0.549

High

158885

WDR55
WD repeat-containing protein 55

2

7

High-throughput

0.549

High

158749

SODC
Superoxide dismutase [Cu-Zn]

1

4

High-throughput

0.536

High

158755

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.536

High

158780

ARRB2
Beta-arrestin-2

1

11

High-throughput

0.536

High

158785

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.536

High

158789

ARRB1
Beta-arrestin-1

1

11

High-throughput

0.536

High

158832

VIR
Protein virilizer homolog

2

4

High-throughput

0.533

High

158863

FBXW7
F-box/WD repeat-containing protein 7

2

8

Small-scale

0.533

High

158899

NUDC
Nuclear migration protein nudC

2

4

High-throughput

0.533

High

158796

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

11

High-throughput

0.521

High

158894

DUX4
Double homeobox protein 4

1

9

High-throughput

0.516

High

158753

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

158878

KLC2
Kinesin light chain 2

1

0

High-throughput

0.513

High

158791

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.508

High

158801

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.501

High

158760

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

14

High-throughput

0.500

High

158739

NUAK1
NUAK family SNF1-like kinase 1

1

3

High-throughput

0.489

High

158797

JAK3
Tyrosine-protein kinase JAK3

1

18

High-throughput

0.489

High

158824

ZN460
Zinc finger protein 460

1

1

High-throughput

0.489

High

158828

MK06
Mitogen-activated protein kinase 6

1

6

High-throughput

0.489

High

158844

MYLK4
Myosin light chain kinase family member 4

1

4

High-throughput

0.489

High

158848

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

1

High-throughput

0.489

High

158849

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.489

High

158859

NEK7
Serine/threonine-protein kinase Nek7

1

7

High-throughput

0.489

High

158867

AURKB
Aurora kinase B

1

3

High-throughput

0.489

High

158877

NUAK2
NUAK family SNF1-like kinase 2

1

2

High-throughput

0.489

High

158901

SIK3
Serine/threonine-protein kinase SIK3

1

1

High-throughput

0.489

High

158734

XPO1
Exportin-1

1

20

High-throughput

0.479

High

158735

TGON2
Trans-Golgi network integral membrane protein 2

1

15

High-throughput

0.479

High

158737

STX6
Syntaxin-6

1

6

High-throughput

0.479

High

158743

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

158745

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.479

High

158746

HERC2
E3 ubiquitin-protein ligase HERC2

1

5

High-throughput

0.479

High

158747

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

158750

EGFR
Epidermal growth factor receptor

1

15

High-throughput

0.479

High

158751

PGK1
Phosphoglycerate kinase 1

1

1

High-throughput

0.479

High

158754

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

158756

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

158757

P53
Cellular tumor antigen p53

1

5

High-throughput

0.479

High

158759

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

158761

CLCA
Clathrin light chain A

1

17

High-throughput

0.479

High

158762

CLCB
Clathrin light chain B

1

15

Small-scale

0.479

High

158763

PARP1
Poly [ADP-ribose] polymerase 1

1

8

High-throughput

0.479

High

158766

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

158768

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.479

High

158769

NCAM1
Neural cell adhesion molecule 1

1

4

High-throughput

0.479

High

158773

RAB4A
Ras-related protein Rab-4A

1

6

High-throughput

0.479

High

158774

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

2

High-throughput

0.479

High

158775

PAR1
Proteinase-activated receptor 1

1

3

Small-scale

0.479

High

158776

EF1G
Elongation factor 1-gamma

1

2

High-throughput

0.479

High

158779

STIP1
Stress-induced-phosphoprotein 1

1

6

High-throughput

0.479

High

158782

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

158784

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

8

High-throughput

0.479

High

158788

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

158790

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

16

Small-scale

0.479

High

158794

MECP2
Methyl-CpG-binding protein 2

1

2

High-throughput

0.479

High

158799

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

158807

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

158810

CLH1
Clathrin heavy chain 1

1

9

Small-scale

0.479

High

158811

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

158812

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

158817

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.479

High

158821

SQSTM
Sequestosome-1

1

8

High-throughput

0.479

High

158822

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

14

High-throughput

0.479

High

158825

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

158826

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

8

High-throughput

0.479

High

158827

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.479

High

158833

LTOR1
Ragulator complex protein LAMTOR1

1

7

High-throughput

0.479

High

158839

ATG9A
Autophagy-related protein 9A

1

7

High-throughput

0.479

High

158864

VP33A
Vacuolar protein sorting-associated protein 33A

1

6

Small-scale

0.479

High

158865

OPTN
Optineurin

1

11

High-throughput

0.479

High

158868

DDRGK
DDRGK domain-containing protein 1

1

5

High-throughput

0.479

High

158869

VPS39
Vam6/Vps39-like protein

1

10

Small-scale

0.479

High

158874

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

158879

ATG5
Autophagy protein 5

1

5

High-throughput

0.479

High

158881

VP33B
Vacuolar protein sorting-associated protein 33B

1

6

Small-scale

0.479

High

158893

CALY
Neuron-specific vesicular protein calcyon

1

1

Small-scale

0.479

High

158897

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

158786

CCNF
Cyclin-F

1

5

High-throughput

0.470

High

128609

MEN1
Menin

1

0

High-throughput

0.458

High

158803

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.458

High

158841

PEG10
Retrotransposon-derived protein PEG10

1

0

Small-scale

0.458

High

158815

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.457

High

104058

F5H1C8
Solute carrier family 15 member 3

1

8

High-throughput

0.445

High

158764

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

158829

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

High-throughput

0.445

High

158835

MFS12
Major facilitator superfamily domain-containing protein 12

1

3

High-throughput

0.445

High

158852

S15A4
Solute carrier family 15 member 4

1

8

High-throughput

0.445

High

158876

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

158891

S17A5
Sialin

1

1

High-throughput

0.445

High

158892

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

6

High-throughput

0.445

High

104830

APRIO
Alternative prion protein

1

8

High-throughput

0.437

High

158740

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.437

High

158741

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.437

High

158742

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

Small-scale

0.437

High

158748

AGR2
Anterior gradient protein 2 homolog

1

9

High-throughput

0.437

High

158758

LCK
Tyrosine-protein kinase Lck

1

9

High-throughput

0.437

High

158770

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

158771

VGFR1
Vascular endothelial growth factor receptor 1

1

8

High-throughput

0.437

High

158777

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

158778

PML
Protein PML

1

8

High-throughput

0.437

High

158781

GRK5
G protein-coupled receptor kinase 5

1

5

High-throughput

0.437

High

158783

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

158804

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.437

High

158806

H2B1C
Histone H2B type 1-C/E/F/G/I

1

5

High-throughput

0.437

High

158816

RFA4
Replication protein A 30 kDa subunit

1

9

High-throughput

0.437

High

158818

TIF1B
Transcription intermediary factor 1-beta

1

7

High-throughput

0.437

High

158823

RBM39
RNA-binding protein 39

1

3

High-throughput

0.437

High

158831

RNF43
E3 ubiquitin-protein ligase RNF43

1

7

High-throughput

0.437

High

158836

LRC31
Leucine-rich repeat-containing protein 31

1

3

High-throughput

0.437

High

158837

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

158840

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.437

High

158842

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.437

High

158846

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

2

High-throughput

0.437

High

158850

NIN
Ninein

1

3

High-throughput

0.437

High

158851

FBXL6
F-box/LRR-repeat protein 6

1

6

High-throughput

0.437

High

158861

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

8

High-throughput

0.437

High

158875

YTHD1
YTH domain-containing family protein 1

1

9

High-throughput

0.437

High

158884

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

158886

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

158888

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.437

High

158889

CPAP
Centrosomal P4.1-associated protein

1

4

High-throughput

0.437

High

158890

BRD7
Bromodomain-containing protein 7

1

14

High-throughput

0.437

High

158895

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

158896

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

158898

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.437

High

158903

YTHD2
YTH domain-containing family protein 2

1

9

High-throughput

0.437

High

158813

P
P protein

1

0

High-throughput

0.426

High

158787

MAGAA
Melanoma-associated antigen 10

1

5

High-throughput

0.407

High

158814

BTK
Tyrosine-protein kinase BTK

1

11

High-throughput

0.407

High

158834

S18B1
MFS-type transporter SLC18B1

1

4

High-throughput

0.407

High

158847

S38A6
Solute carrier family 38 member 6

1

1

High-throughput

0.407

High

158872

FRMD6
FERM domain-containing protein 6

1

9

High-throughput

0.407

High

158883

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.407

High

158792

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.279

Low

158843

COMD2
COMM domain-containing protein 2

1

0

High-throughput

0.279

Low

158880

TSN10
Tetraspanin-10

1

0

High-throughput

0.279

Low

158767

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

158830

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

158838

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

Small-scale

0.249

Low

158855

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low

158857

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

158860

P66B
Transcriptional repressor p66-beta

1

0

High-throughput

0.249

Low

158870

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.249

Low

158871

HS12B
Heat shock 70 kDa protein 12B

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025