HitPredict

Interactor 1: TIMP1 (P01033)
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Gene: TIMP1

Interactor 2: MMP1 (P03956)
Interstitial collagenase (EC 3.4.24.7) (Fibroblast collagenase) (Matrix metalloproteinase-1) (MMP-1) [Cleaved into: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase]
Gene: MMP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.838

The method score is based on:

Property Details
Experiments 9063449, 12475252
Identification Methods pull down, coimmunoprecipitation, surface plasmon resonance, enzymatic study
Interaction Type direct interaction, physical association, enzymatic reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008270 - zinc ion binding
GO:0031012 - extracellular matrix
GO:0071492 - cellular response to UV-A
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 207
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024