HitPredict

Interactor 1: TIMP1 (P01033)
Metalloproteinase inhibitor 1 (Erythroid-potentiating activity) (EPA) (Fibroblast collagenase inhibitor) (Collagenase inhibitor) (Tissue inhibitor of metalloproteinases 1) (TIMP-1)
Gene: TIMP1

Interactor 2: MMP3 (P08254)
Stromelysin-1 (SL-1) (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1)
Gene: MMP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.806

Property	Details
Experiments	9288970, 12475252
Identification Methods	x-ray crystallography, surface plasmon resonance, enzymatic study
Interaction Type	association, direct interaction, enzymatic reaction

Property	Details
Interacting Pfam domains	Hemopexin~TIMP, Peptidase_M10~TIMP
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008270 - zinc ion binding GO:0031012 - extracellular matrix GO:0071492 - cellular response to UV-A
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 207 Hs			1 477
+	Hs
		344784 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP10_HUMAN (1-477): 0: 648: 77.99
+	Hs
		439275 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP3_HUMAN (1-477): 0: 676: 100.00
+	Hs
		344777 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP1_HUMAN (14-477): 0: 615: 53.55
+	Hs
		439265 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP3_HUMAN (1-477): 0: 676: 100.00
+	Hs
		439263 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP3_HUMAN (1-477): 0: 676: 100.00
+	Hs
		372742 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP1_HUMAN (14-477): 0: 615: 53.55
+	Hs
		344795 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP14_HUMAN (34-477): 0: 559: 38.21
+	Mm
		706099 TIMP3_MOUSE (10-199): 6.2e-84: 249: 38.46		MMP13_MOUSE (3-477): 0: 625: 49.06
+	Hs
		372726 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP1_HUMAN (14-477): 0: 615: 53.55
+	Hs
		838537 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP14_HUMAN (34-477): 0: 559: 38.21
+	Hs
		554810 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP16_HUMAN (6-477): 0: 573: 35.37
+	Hs
		726505 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP14_HUMAN (34-477): 0: 559: 38.21
+	Hs
		554808 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP14_HUMAN (34-477): 0: 559: 38.21
+	Hs
		554809 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP15_HUMAN (34-477): 0: 544: 34.96
+	Hs
		344780 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55
+	Hs
		344786 TIMP1_HUMAN (1-207): 5.49e-112: 320: 100.00		MMP9_HUMAN (13-204): 2.95e-71: 241: 45.77
+	Hs
		439254 TIMP4_HUMAN (17-199): 2.91e-92: 270: 34.92		MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55
+	Hs
		439230 TIMP3_HUMAN (10-199): 5.9e-87: 257: 38.97		MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55
+	Hs
		439223 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP2_HUMAN (5-204): 3.86e-82: 268: 47.55
+	Hs
		540409 TIMP2_HUMAN (20-199): 3.71e-82: 245: 40.96		MMP9_HUMAN (13-204): 2.95e-71: 241: 45.77