Protein: AP2A2
AP-2 complex subunit alpha-2 (100 kDa coated vesicle protein C) (Adaptor protein complex AP-2 subunit alpha-2) (Adaptor-related protein complex 2 subunit alpha-2) (Alpha-adaptin C) (Alpha2-adaptin) (Clathrin assembly protein complex 2 alpha-C large chain) (Huntingtin yeast partner J) (Huntingtin-interacting protein 9) (HIP-9) (Huntingtin-interacting protein J) (Plasma membrane adaptor HA2/AP2 adaptin alpha C subunit)

Gene: AP2A2
Organism: Homo sapiens
Interactions: 198
UniProt ID: O94973

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006886 - intracellular protein transport
GO:0008289 - lipid binding
GO:0009898 - cytoplasmic side of plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

323765

AP2M1
AP-2 complex subunit mu

7

20

High-throughput

0.966

High

323697

AP2B1
AP-2 complex subunit beta

5

15

High-throughput

0.922

High

323791

NECP2
Adaptin ear-binding coat-associated protein 2

4

12

High-throughput

0.903

High

323690

AP2S1
AP-2 complex subunit sigma

4

20

High-throughput

0.900

High

323638

AP2A1
AP-2 complex subunit alpha-1

4

15

High-throughput

0.873

High

323703

CLH1
Clathrin heavy chain 1

3

9

Small-scale

0.854

High

323709

AP1B1
AP-1 complex subunit beta-1

2

14

High-throughput

0.776

High

323641

EGFR
Epidermal growth factor receptor

6

14

Small-scale

0.736

High

323667

SHC1
SHC-transforming protein 1

5

17

Small-scale

0.720

High

323676

EPS15
Epidermal growth factor receptor substrate 15

5

20

Small-scale

0.717

High

323741

AAGAB
Alpha- and gamma-adaptin-binding protein p34

5

3

High-throughput

0.717

High

323683

AMPH
Amphiphysin

4

20

Small-scale

0.694

High

323758

NECP1
Adaptin ear-binding coat-associated protein 1

1

12

High-throughput

0.691

High

323654

CLCB
Clathrin light chain B

3

13

High-throughput

0.667

High

323756

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

3

13

High-throughput

0.662

High

323808

SNX9
Sorting nexin-9

3

6

High-throughput

0.662

High

323719

RNPS1
RNA-binding protein with serine-rich domain 1

3

4

High-throughput

0.643

High

323715

EPN4
Clathrin interactor 1

2

20

High-throughput

0.628

High

323749

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.628

High

323760

GP156
Probable G-protein coupled receptor 156

2

2

High-throughput

0.628

High

323658

TAU
Microtubule-associated protein tau

3

17

Small-scale

0.624

High

323635

AP2A2
AP-2 complex subunit alpha-2

1

15

High-throughput

0.618

High

323653

CLCA
Clathrin light chain A

2

15

High-throughput

0.611

High

323748

ZBT46
Zinc finger and BTB domain-containing protein 46

3

5

High-throughput

0.609

High

323657

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

15

High-throughput

0.602

High

323705

OCRL
Inositol polyphosphate 5-phosphatase OCRL

2

12

High-throughput

0.601

High

323766

REPS1
RalBP1-associated Eps domain-containing protein 1

2

20

High-throughput

0.601

High

159443

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

7

Small-scale

0.584

High

323686

FXR1
RNA-binding protein FXR1

2

6

High-throughput

0.584

High

323702

DAB2
Disabled homolog 2

2

20

Small-scale

0.584

High

323801

MYO6
Unconventional myosin-VI

2

6

Small-scale

0.584

High

323677

HD
Huntingtin

2

7

Small-scale

0.576

High

323732

RUN3A
RUN domain-containing protein 3A

2

5

High-throughput

0.574

High

323785

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.574

High

323681

PAXI
Paxillin

2

3

High-throughput

0.571

High

323691

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.571

High

323706

KPCZ
Protein kinase C zeta type

2

4

High-throughput

0.571

High

323724

ITSN1
Intersectin-1

2

20

High-throughput

0.571

High

323809

EPN1
Epsin-1

1

20

Small-scale

0.561

High

155642

FCHO1
F-BAR domain only protein 1

1

10

High-throughput

0.536

High

171645

GAK
Cyclin-G-associated kinase

1

18

High-throughput

0.536

High

177154

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

2

High-throughput

0.536

High

323644

FINC
Fibronectin

1

4

High-throughput

0.536

High

323663

COMT
Catechol O-methyltransferase

1

3

High-throughput

0.536

High

323668

ARRB2
Beta-arrestin-2

1

8

High-throughput

0.536

High

323678

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.536

High

323679

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

323689

KIF11
Kinesin-like protein KIF11

1

6

High-throughput

0.536

High

323707

CALD1
Caldesmon

1

17

High-throughput

0.536

High

323713

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

323720

RBP1
RalA-binding protein 1

1

10

High-throughput

0.536

High

323772

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

18

High-throughput

0.536

High

323778

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

High-throughput

0.536

High

323794

GTSE1
G2 and S phase-expressed protein 1

1

4

High-throughput

0.536

High

323797

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

20

High-throughput

0.536

High

323799

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

323661

RFA2
Replication protein A 32 kDa subunit

2

6

High-throughput

0.533

High

323666

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

5

High-throughput

0.533

High

323672

RFA3
Replication protein A 14 kDa subunit

2

5

High-throughput

0.533

High

323789

BMP2K
BMP-2-inducible protein kinase

2

18

High-throughput

0.533

High

323645

TFR1
Transferrin receptor protein 1

1

4

High-throughput

0.515

High

323806

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.513

High

323723

SMAD1
Mothers against decapentaplegic homolog 1

1

2

High-throughput

0.508

High

323651

A4
Amyloid-beta precursor protein

1

4

High-throughput

0.501

High

323792

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

6

Small-scale

0.501

High

323664

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

4

High-throughput

0.489

High

323700

M3K9
Mitogen-activated protein kinase kinase kinase 9

1

5

High-throughput

0.489

High

323725

DREB
Drebrin

1

8

High-throughput

0.489

High

323728

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

323747

LYRIC
Protein LYRIC

1

2

High-throughput

0.489

High

323761

ZCH10
Zinc finger CCHC domain-containing protein 10

1

3

High-throughput

0.489

High

323767

INT4
Integrator complex subunit 4

1

1

High-throughput

0.489

High

323774

CCD32
Coiled-coil domain-containing protein 32

1

1

High-throughput

0.489

High

323779

WNK3
Serine/threonine-protein kinase WNK3

1

7

High-throughput

0.489

High

323783

PAAT
ATPase PAAT

1

1

High-throughput

0.489

High

323796

NLGN3
Neuroligin-3

1

0

Small-scale

0.486

High

136758

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

138424

BIN1
Myc box-dependent-interacting protein 1

1

20

Small-scale

0.479

High

156797

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

178127

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

215887

SYNJ1
Synaptojanin-1

1

12

High-throughput

0.479

High

217645

TGON2
Trans-Golgi network integral membrane protein 2

1

12

High-throughput

0.479

High

222601

PRC1
Protein regulator of cytokinesis 1

1

10

High-throughput

0.479

High

225892

STX6
Syntaxin-6

1

5

High-throughput

0.479

High

245771

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

3

Small-scale

0.479

High

249807

STX10
Syntaxin-10

1

6

High-throughput

0.479

High

279250

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

323637

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

323639

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

323642

CAH2
Carbonic anhydrase 2

1

1

High-throughput

0.479

High

323646

ESR1
Estrogen receptor

1

11

Small-scale

0.479

High

323647

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

323649

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.479

High

323650

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

Small-scale

0.479

High

323652

ISG15
Ubiquitin-like protein ISG15

1

18

High-throughput

0.479

High

323655

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

323656

FURIN
Furin

1

2

High-throughput

0.479

High

323659

LAMP1
Lysosome-associated membrane glycoprotein 1

1

8

High-throughput

0.479

High

323660

IFM1
Interferon-induced transmembrane protein 1

1

8

High-throughput

0.479

High

323662

RHOQ
Rho-related GTP-binding protein RhoQ

1

10

High-throughput

0.479

High

323669

GRK5
G protein-coupled receptor kinase 5

1

4

High-throughput

0.479

High

323673

BASI
Basigin

1

5

High-throughput

0.479

High

323674

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

323684

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

323687

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

323688

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

High-throughput

0.479

High

323692

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

High-throughput

0.479

High

323693

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

323694

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

323695

GRB2
Growth factor receptor-bound protein 2

1

18

Small-scale

0.479

High

323696

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

323698

YBOX1
Y-box-binding protein 1

1

1

Small-scale

0.479

High

323704

IFM3
Interferon-induced transmembrane protein 3

1

8

High-throughput

0.479

High

323708

EP300
Histone acetyltransferase p300

1

14

High-throughput

0.479

High

323710

PICAL
Phosphatidylinositol-binding clathrin assembly protein

1

15

High-throughput

0.479

High

323711

SQSTM
Sequestosome-1

1

6

High-throughput

0.479

High

323716

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

323717

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

323718

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

323721

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.479

High

323726

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

323727

AAK1
AP2-associated protein kinase 1

1

20

High-throughput

0.479

High

323731

MIDN
Midnolin

1

2

High-throughput

0.479

High

323733

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

15

High-throughput

0.479

High

323739

LTOR1
Ragulator complex protein LAMTOR1

1

6

High-throughput

0.479

High

323742

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

1

2

High-throughput

0.479

High

323743

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

323746

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

323750

MIB1
E3 ubiquitin-protein ligase MIB1

1

6

High-throughput

0.479

High

323753

RHG18
Rho GTPase-activating protein 18

1

8

High-throughput

0.479

High

323754

FBXW8
F-box/WD repeat-containing protein 8

1

5

High-throughput

0.479

High

323757

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

323759

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

13

High-throughput

0.479

High

323763

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

323775

RN126
E3 ubiquitin-protein ligase RNF126

1

4

High-throughput

0.479

High

323776

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

323781

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

Small-scale

0.479

High

323782

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.479

High

323787

BRD7
Bromodomain-containing protein 7

1

12

High-throughput

0.479

High

323788

ANLN
Anillin

1

3

High-throughput

0.479

High

323790

RNF12
E3 ubiquitin-protein ligase RLIM

1

10

High-throughput

0.479

High

323793

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

5

High-throughput

0.479

High

323795

TLS1
Splicing factor C9orf78

1

4

High-throughput

0.479

High

323798

HDAC6
Protein deacetylase HDAC6

1

4

High-throughput

0.479

High

323802

ALK
ALK tyrosine kinase receptor

1

18

High-throughput

0.479

High

323803

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

4

High-throughput

0.479

High

323804

LZTS1
Leucine zipper putative tumor suppressor 1

1

10

High-throughput

0.479

High

323671

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

323730

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

0

High-throughput

0.458

High

254694

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

323670

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

323680

SL9A3
Sodium/hydrogen exchanger 3

1

5

High-throughput

0.445

High

323685

NUMB
Protein numb homolog

1

20

Small-scale

0.445

High

323701

RHOG
Rho-related GTP-binding protein RhoG

1

9

Small-scale

0.445

High

323734

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

323740

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.445

High

323762

MOT10
Monocarboxylate transporter 10

1

4

High-throughput

0.445

High

323769

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

2

High-throughput

0.445

High

323780

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

323810

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

2

High-throughput

0.445

High

105000

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

139787

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.437

High

247577

NUPR1
Nuclear protein 1

1

2

High-throughput

0.437

High

314972

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.437

High

323636

HEXI1
Protein HEXIM1

1

7

High-throughput

0.437

High

323640

AGR2
Anterior gradient protein 2 homolog

1

6

High-throughput

0.437

High

323643

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

323675

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.437

High

323682

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

323699

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.437

High

323714

UBP2L
Ubiquitin-associated protein 2-like

1

10

High-throughput

0.437

High

323736

RC3H1
Roquin-1

1

5

High-throughput

0.437

High

323737

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

5

Small-scale

0.437

High

323738

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

2

High-throughput

0.437

High

323744

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

323745

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

323752

SLX4
Structure-specific endonuclease subunit SLX4

1

9

High-throughput

0.437

High

323755

FBXL6
F-box/LRR-repeat protein 6

1

4

High-throughput

0.437

High

323764

ESR2
Estrogen receptor beta

1

11

High-throughput

0.437

High

323768

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.437

High

323770

KCD15
BTB/POZ domain-containing protein KCTD15

1

8

Small-scale

0.437

High

323777

YTHD1
YTH domain-containing family protein 1

1

7

High-throughput

0.437

High

323784

RC3H2
Roquin-2

1

13

High-throughput

0.437

High

323786

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

323800

XPO7
Exportin-7

1

16

High-throughput

0.437

High

323805

RNF6
E3 ubiquitin-protein ligase RNF6

1

10

High-throughput

0.437

High

323712

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

0

High-throughput

0.426

High

323665

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.407

High

323735

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

323751

MFS6L
Major facilitator superfamily domain-containing protein 6-like

1

4

High-throughput

0.407

High

323771

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

323773

S35A5
UDP-sugar transporter protein SLC35A5

1

1

High-throughput

0.407

High

323648

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

66970

CPS4L
Putative cleavage and polyadenylation specificity factor subunit 4-like protein

1

0

High-throughput

0.279

Low

323807

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

323722

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

323729

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025