HitPredict

Interactor 1: CYTC (P01034)
Cystatin-C (Cystatin-3) (Gamma-trace) (Neuroendocrine basic polypeptide) (Post-gamma-globulin)
Gene: CST3

Interactor 2: CATB (P07858)
Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Gene: CTSB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	14503883, 33961781
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cystatin~Peptidase_C1
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0070062 - extracellular exosome GO:1904813 - ficolin-1-rich granule lumen
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 146 Hs			1 339
+	Hs
		245769 CYTC_HUMAN (1-146): 7.05e-55: 170: 100.00		CATL2_HUMAN (14-328): 6.76e-98: 294: 22.66
+	Hs
		344815 CYTC_HUMAN (1-146): 7.05e-55: 170: 100.00		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		245770 CYTN_HUMAN (27-146): 1.44e-51: 162: 55.37		CATL2_HUMAN (14-328): 6.76e-98: 294: 22.66
+	Hs
		344922 CYTN_HUMAN (27-146): 1.44e-51: 162: 55.37		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		344817 CYTC_HUMAN (1-146): 7.05e-55: 170: 100.00		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32
+	Hs
		637215 CYTD_HUMAN (1-144): 1.61e-50: 159: 50.35		CATS_HUMAN (18-328): 2.8e-94: 285: 24.07
+	Hs
		344926 CYTN_HUMAN (27-146): 1.44e-51: 162: 55.37		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32
+	Hs
		344822 CYTC_HUMAN (1-146): 7.05e-55: 170: 100.00		CATC_HUMAN (20-330): 1.2e-87: 272: 29.05
+	Hs
		453952 CYTD_HUMAN (1-144): 1.61e-50: 159: 50.35		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32
+	Hs
		283668 CYTF_HUMAN (5-143): 4.24e-43: 141: 32.88		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		245811 CYTM_HUMAN (1-143): 7.88e-39: 130: 34.90		CATL2_HUMAN (14-328): 6.76e-98: 294: 22.66
+	Hs
		429900 CYTM_HUMAN (1-143): 7.88e-39: 130: 34.90		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		283671 CYTF_HUMAN (5-143): 4.24e-43: 141: 32.88		CATC_HUMAN (20-330): 1.2e-87: 272: 29.05
+	Hs
		863738 CYTM_HUMAN (1-143): 7.88e-39: 130: 34.90		CATC_HUMAN (20-330): 1.2e-87: 272: 29.05
+	Hs
		245772 KNG1_HUMAN (12-128): 9.05e-17: 77.6: 18.80		CATL2_HUMAN (14-328): 6.76e-98: 294: 22.66
+	Hs
		345171 KNG1_HUMAN (12-128): 9.05e-17: 77.6: 18.80		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		345173 KNG1_HUMAN (12-128): 9.05e-17: 77.6: 18.80		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32