HitPredict

Interactor 1: CYTA (P01040)
Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]
Gene: CSTA

Interactor 2: CATB (P07858)
Cathepsin B (EC 3.4.22.1) (APP secretase) (APPS) (Cathepsin B1) [Cleaved into: Cathepsin B light chain; Cathepsin B heavy chain]
Gene: CTSB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	14503883, 9585570, 33961781, 20860624
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation, x-ray crystallography
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Cystatin~Peptidase_C1
Common GO terms	GO:0005615 - extracellular space GO:1904090 - peptidase inhibitor complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 98 Hs			1 339
+	Hs
		376060 CYTB_HUMAN (1-98): 7.38e-54: 164: 53.06		CATB_HUMAN (1-339): 3.32e-161: 455: 100.00
+	Hs
		376059 CYTB_HUMAN (1-98): 7.38e-54: 164: 53.06		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		245771 CYTA_HUMAN (1-98): 2.93e-49: 152: 100.00		CATL2_HUMAN (14-328): 6.76e-98: 294: 22.66
+	Hs
		345044 CYTA_HUMAN (1-98): 2.93e-49: 152: 100.00		CATL1_HUMAN (24-328): 2.24e-97: 293: 21.50
+	Hs
		376061 CYTB_HUMAN (1-98): 7.38e-54: 164: 53.06		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32
+	Hs
		345047 CYTA_HUMAN (1-98): 2.93e-49: 152: 100.00		CATH_HUMAN (32-332): 9.32e-93: 281: 23.32
+	Hs
		345065 CYTA_HUMAN (1-98): 2.93e-49: 152: 100.00		CATC_HUMAN (20-330): 1.2e-87: 272: 29.05