Protein: TNR5
Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)

Gene: TNR5, CD40
Organism: Homo sapiens
Interactions: 232
UniProt ID: P25942

Gene Ontology (top 5):
GO:0002768 - immune response-regulating cell surface receptor signaling pathway
GO:0003823 - antigen binding
GO:0005886 - plasma membrane
GO:0006874 - intracellular calcium ion homeostasis
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683203

CD40L
CD40 ligand

3

20

Small-scale

0.827

High

683372

TN13B
Tumor necrosis factor ligand superfamily member 13B

2

4

Small-scale

0.776

High

683232

TRAF2
TNF receptor-associated factor 2

32

20

Small-scale

0.769

High

683234

TRAF3
TNF receptor-associated factor 3

28

20

Small-scale

0.768

High

683378

TRAF6
TNF receptor-associated factor 6

14

20

Small-scale

0.761

High

136662

TRAF5
TNF receptor-associated factor 5

11

20

Small-scale

0.754

High

683233

TRAF1
TNF receptor-associated factor 1

5

20

Small-scale

0.703

High

683237

BIRC2
Baculoviral IAP repeat-containing protein 2

4

12

Small-scale

0.672

High

683351

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

3

2

High-throughput

0.665

High

683205

CTR1
High affinity cationic amino acid transporter 1

3

6

High-throughput

0.647

High

225402

CIKS
E3 ubiquitin ligase TRAF3IP2

3

0

Small-scale

0.622

High

683200

TNR5
Tumor necrosis factor receptor superfamily member 5

1

15

Small-scale

0.618

High

683204

MIP
Lens fiber major intrinsic protein

2

1

High-throughput

0.606

High

683224

MYPR
Myelin proteolipid protein

2

2

High-throughput

0.606

High

683260

MFSD5
Molybdate-anion transporter

2

1

High-throughput

0.606

High

683286

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

2

1

High-throughput

0.606

High

683323

ZNT3
Probable proton-coupled zinc antiporter SLC30A3

2

4

High-throughput

0.606

High

683326

ZNT2
Proton-coupled zinc antiporter SLC30A2

2

4

High-throughput

0.606

High

271668

HIP1R
Huntingtin-interacting protein 1-related protein

2

5

High-throughput

0.601

High

683212

MTOR
Serine/threonine-protein kinase mTOR

2

11

High-throughput

0.601

High

683267

NBEL2
Neurobeachin-like protein 2

2

7

High-throughput

0.601

High

683272

MON2
Protein MON2 homolog

2

8

High-throughput

0.601

High

683281

S39AB
Zinc transporter ZIP11

2

10

High-throughput

0.601

High

683285

F241A
Uncharacterized protein FAM241A

2

1

High-throughput

0.601

High

683292

CIP2A
Protein CIP2A

2

1

High-throughput

0.601

High

683303

TNPO1
Transportin-1

2

14

High-throughput

0.601

High

683356

ATX10
Ataxin-10

2

1

High-throughput

0.601

High

536536

HSP7C
Heat shock cognate 71 kDa protein

2

6

Small-scale

0.584

High

683210

STAT1
Signal transducer and activator of transcription 1-alpha/beta

2

2

Small-scale

0.584

High

683306

TLCD1
TLC domain-containing protein 1

2

0

High-throughput

0.580

High

683330

TM147
BOS complex subunit TMEM147

2

0

High-throughput

0.580

High

683223

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.576

High

683226

COG7
Conserved oligomeric Golgi complex subunit 7

2

0

High-throughput

0.576

High

683270

DYM
Dymeclin

2

0

High-throughput

0.576

High

683314

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.576

High

683319

XPO6
Exportin-6

2

0

High-throughput

0.576

High

683331

NUP85
Nuclear pore complex protein Nup85

2

0

High-throughput

0.576

High

683357

NCDN
Neurochondrin

2

0

High-throughput

0.576

High

683369

EXOC7
Exocyst complex component 7

2

0

High-throughput

0.576

High

683367

FAF1
FAS-associated factor 1

1

7

Small-scale

0.573

High

683302

TANK
TRAF family member-associated NF-kappa-B activator

2

1

Small-scale

0.563

High

683206

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.561

High

683312

S39AD
Zinc transporter ZIP13

2

10

High-throughput

0.553

High

164531

TNPO2
Transportin-2

2

14

High-throughput

0.549

High

189110

IPO8
Importin-8

2

12

High-throughput

0.549

High

318115

IPO13
Importin-13

2

17

High-throughput

0.549

High

683207

PEX19
Peroxisomal biogenesis factor 19

2

1

High-throughput

0.549

High

683213

EI2BB
Translation initiation factor eIF2B subunit beta

2

2

High-throughput

0.549

High

683238

ATR
Serine/threonine-protein kinase ATR

2

7

High-throughput

0.549

High

683244

KIF14
Kinesin-like protein KIF14

2

4

High-throughput

0.549

High

683262

TTI2
TELO2-interacting protein 2

2

1

High-throughput

0.549

High

683266

THADA
tRNA

2

1

High-throughput

0.549

High

683278

HOOK3
Protein Hook homolog 3

2

6

High-throughput

0.549

High

683299

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

2

7

High-throughput

0.549

High

683310

SAAL1
Protein SAAL1

2

1

High-throughput

0.549

High

683317

COG8
Conserved oligomeric Golgi complex subunit 8

2

1

High-throughput

0.549

High

683332

FACD2
Fanconi anemia group D2 protein

2

2

High-throughput

0.549

High

683333

XPO4
Exportin-4

2

7

High-throughput

0.549

High

683334

INT2
Integrator complex subunit 2

2

1

High-throughput

0.549

High

683337

HEAT1
HEAT repeat-containing protein 1

2

1

High-throughput

0.549

High

683340

XPO5
Exportin-5

2

14

High-throughput

0.549

High

683346

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

2

1

High-throughput

0.549

High

683363

IPO11
Importin-11

2

10

High-throughput

0.549

High

683379

TNPO3
Transportin-3

2

20

High-throughput

0.549

High

193676

TPSN
Tapasin

1

0

High-throughput

0.546

High

162783

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

5

High-throughput

0.536

High

683220

CTR2
Cationic amino acid transporter 2

1

7

High-throughput

0.536

High

683222

XPO2
Exportin-2

1

15

High-throughput

0.536

High

683240

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.536

High

683246

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

5

High-throughput

0.536

High

683293

GEMI5
Gem-associated protein 5

1

3

High-throughput

0.536

High

683304

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

11

High-throughput

0.536

High

683342

AT131
Endoplasmic reticulum transmembrane helix translocase

1

14

High-throughput

0.536

High

683359

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.536

High

122915

SGK1
Serine/threonine-protein kinase Sgk1

1

9

High-throughput

0.515

High

528192

THIO
Thioredoxin

1

1

High-throughput

0.515

High

651157

CBL
E3 ubiquitin-protein ligase CBL

1

10

Small-scale

0.515

High

665024

IL4RA
Interleukin-4 receptor subunit alpha

1

6

Small-scale

0.515

High

683201

CALR
Calreticulin

1

2

High-throughput

0.515

High

683218

JAK3
Tyrosine-protein kinase JAK3

1

20

Small-scale

0.515

High

683327

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.515

High

683353

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.515

High

339136

TYDP2
Tyrosyl-DNA phosphodiesterase 2

1

2

Small-scale

0.504

High

557873

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.501

High

559227

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.501

High

683241

NCOA6
Nuclear receptor coactivator 6

1

2

Small-scale

0.501

High

683375

TR150
Thyroid hormone receptor-associated protein 3

1

2

Small-scale

0.501

High

643692

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.493

High

683208

RFC5
Replication factor C subunit 5

1

0

High-throughput

0.493

High

231447

ORC4
Origin recognition complex subunit 4

1

7

High-throughput

0.489

High

683221

NUP98
Nuclear pore complex protein Nup98-Nup96

1

3

High-throughput

0.489

High

683235

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

1

High-throughput

0.489

High

683248

SMN
Survival motor neuron protein

1

1

High-throughput

0.489

High

683254

BIG3
Brefeldin A-inhibited guanine nucleotide-exchange protein 3

1

5

High-throughput

0.489

High

683256

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.489

High

683283

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.489

High

683296

STAG1
Cohesin subunit SA-1

1

1

High-throughput

0.489

High

683301

GCN1
Stalled ribosome sensor GCN1

1

9

High-throughput

0.489

High

683338

REEP4
Receptor expression-enhancing protein 4

1

1

High-throughput

0.489

High

683362

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.489

High

683381

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

8

High-throughput

0.489

High

683382

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

8

High-throughput

0.489

High

683229

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.480

High

167823

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

17

Small-scale

0.479

High

177797

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

18

Small-scale

0.479

High

185439

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.479

High

214387

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

10

Small-scale

0.479

High

216629

HTRA2
Serine protease HTRA2, mitochondrial

1

2

Small-scale

0.479

High

347536

BAG3
BAG family molecular chaperone regulator 3

1

3

High-throughput

0.479

High

683202

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

6

Small-scale

0.479

High

683211

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

5

Small-scale

0.479

High

683225

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

683227

CAV1
Caveolin-1

1

3

Small-scale

0.479

High

683228

REL
Proto-oncogene c-Rel

1

5

Small-scale

0.479

High

683236

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

4

Small-scale

0.479

High

683243

IMB1
Importin subunit beta-1

1

9

Small-scale

0.479

High

683279

STING
Stimulator of interferon genes protein

1

2

Small-scale

0.479

High

683309

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.479

High

683322

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

2

High-throughput

0.479

High

683328

TRAF4
TNF receptor-associated factor 4

1

20

Small-scale

0.479

High

683343

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

Small-scale

0.479

High

683352

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

6

Small-scale

0.479

High

683383

NEMO
NF-kappa-B essential modulator

1

12

Small-scale

0.479

High

683288

ZNT7
Zinc transporter 7

1

4

High-throughput

0.470

High

683298

S39A7
Zinc transporter SLC39A7

1

10

High-throughput

0.470

High

683377

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.470

High

141329

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.458

High

549429

CD20
B-lymphocyte antigen CD20

1

0

Small-scale

0.458

High

643416

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.458

High

683274

AKNA
Microtubule organization protein AKNA

1

0

Small-scale

0.458

High

173659

BTAF1
TATA-binding protein-associated factor 172

1

2

High-throughput

0.445

High

291057

UTP20
Small subunit processome component 20 homolog

1

2

High-throughput

0.445

High

345045

RIGI
Antiviral innate immune response receptor RIG-I

1

2

High-throughput

0.445

High

637844

NF1
Neurofibromin

1

2

High-throughput

0.445

High

683269

UN13D
Protein unc-13 homolog D

1

3

High-throughput

0.445

High

683277

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

High-throughput

0.445

High

683289

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.445

High

683290

EXOC6
Exocyst complex component 6

1

1

High-throughput

0.445

High

683300

ELMO1
Engulfment and cell motility protein 1

1

1

High-throughput

0.445

High

683308

HOOK2
Protein Hook homolog 2

1

6

High-throughput

0.445

High

683349

EXOC1
Exocyst complex component 1

1

1

High-throughput

0.445

High

683361

DDX20
Probable ATP-dependent RNA helicase DDX20

1

1

High-throughput

0.445

High

683365

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.445

High

683371

PLAP
Phospholipase A-2-activating protein

1

3

High-throughput

0.445

High

278240

NCOR1
Nuclear receptor corepressor 1

1

7

Small-scale

0.437

High

282449

KTNA1
Katanin p60 ATPase-containing subunit A1

1

5

High-throughput

0.437

High

683209

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

8

Small-scale

0.437

High

683217

IMA5
Importin subunit alpha-5

1

4

Small-scale

0.437

High

175323

PLXB2
Plexin-B2

1

0

High-throughput

0.426

High

211731

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

248839

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

683214

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.426

High

683216

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.426

High

683249

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.426

High

683271

ARMC9
LisH domain-containing protein ARMC9

1

0

High-throughput

0.426

High

683284

CCYL1
Cyclin-Y-like protein 1

1

0

High-throughput

0.426

High

683311

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.426

High

683315

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.426

High

683324

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.426

High

683341

EPG5
Ectopic P granules protein 5 homolog

1

0

High-throughput

0.426

High

683366

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.426

High

133950

IPO5
Importin-5

1

7

High-throughput

0.407

High

251195

RNBP6
Ran-binding protein 6

1

7

High-throughput

0.407

High

302040

SEGN
Secretagogin

1

1

High-throughput

0.407

High

321891

FRYL
Protein furry homolog-like

1

1

High-throughput

0.407

High

683250

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.407

High

683253

FRY
Protein furry homolog

1

1

High-throughput

0.407

High

683257

ZFY26
Zinc finger FYVE domain-containing protein 26

1

6

High-throughput

0.407

High

683259

ASPH2
Aspartate beta-hydroxylase domain-containing protein 2

1

2

High-throughput

0.407

High

683261

RINT1
RAD50-interacting protein 1

1

1

High-throughput

0.407

High

683264

LCLT1
Lysocardiolipin acyltransferase 1

1

1

High-throughput

0.407

High

683268

NBEL1
Neurobeachin-like protein 1

1

10

High-throughput

0.407

High

683291

TBC15
TBC1 domain family member 15

1

1

High-throughput

0.407

High

683316

ELMO2
Engulfment and cell motility protein 2

1

1

High-throughput

0.407

High

683318

SMG1
Serine/threonine-protein kinase SMG1

1

7

High-throughput

0.407

High

683320

SPAG5
Sperm-associated antigen 5

1

5

High-throughput

0.407

High

683335

CYRIA
CYFIP-related Rac1 interactor A

1

1

High-throughput

0.407

High

683344

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.407

High

683345

F1142
Protein FAM114A2

1

1

High-throughput

0.407

High

683348

MDN1
Midasin

1

6

High-throughput

0.407

High

683355

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.407

High

683358

TFP11
Tuftelin-interacting protein 11

1

1

High-throughput

0.407

High

683364

XPO7
Exportin-7

1

13

High-throughput

0.407

High

683370

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

4

High-throughput

0.407

High

683373

EXC6B
Exocyst complex component 6B

1

1

High-throughput

0.407

High

683376

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.407

High

636198

MAL
Myelin and lymphocyte protein

2

0

High-throughput

0.316

High

683245

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

683251

TM128
Transmembrane protein 128

2

0

High-throughput

0.316

High

683252

DB121
Beta-defensin 121

2

0

High-throughput

0.316

High

683265

TM107
Transmembrane protein 107

2

0

High-throughput

0.316

High

683307

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

683380

INSI2
Insulin-induced gene 2 protein

2

0

High-throughput

0.316

High

137185

EXOC5
Exocyst complex component 5

2

0

High-throughput

0.313

High

208020

TTI1
TELO2-interacting protein 1 homolog

2

0

High-throughput

0.313

High

317797

LTN1
E3 ubiquitin-protein ligase listerin

2

0

High-throughput

0.313

High

683230

NU160
Nuclear pore complex protein Nup160

2

0

High-throughput

0.313

High

683242

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.313

High

683276

GP180
Integral membrane protein GPR180

2

0

High-throughput

0.313

High

683280

DAAF5
Dynein axonemal assembly factor 5

2

0

High-throughput

0.313

High

683294

COG1
Conserved oligomeric Golgi complex subunit 1

2

0

High-throughput

0.313

High

683329

LST8
Target of rapamycin complex subunit LST8

2

0

High-throughput

0.313

High

683339

COG4
Conserved oligomeric Golgi complex subunit 4

2

0

High-throughput

0.313

High

683368

COG5
Conserved oligomeric Golgi complex subunit 5

2

0

High-throughput

0.313

High

683374

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.313

High

683297

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.279

Low

683350

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.279

Low

683219

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.269

Low

683247

B2LA1
Bcl-2-related protein A1

1

0

Small-scale

0.249

Low

683255

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

683321

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.249

Low

244319

NPA1P
Nucleolar pre-ribosomal-associated protein 1

1

0

High-throughput

0.232

Low

252830

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.232

Low

506555

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.232

Low

683215

TSC2
Tuberin

1

0

High-throughput

0.232

Low

683231

IFRD2
Interferon-related developmental regulator 2

1

0

High-throughput

0.232

Low

683239

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

0

High-throughput

0.232

Low

683258

INT3
Integrator complex subunit 3

1

0

High-throughput

0.232

Low

683263

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.232

Low

683273

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.232

Low

683275

NOP9
Nucleolar protein 9

1

0

High-throughput

0.232

Low

683282

VPS8
Vacuolar protein sorting-associated protein 8 homolog

1

0

High-throughput

0.232

Low

683287

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.232

Low

683295

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.232

Low

683305

TBC20
TBC1 domain family member 20

1

0

High-throughput

0.232

Low

683313

INT4
Integrator complex subunit 4

1

0

High-throughput

0.232

Low

683325

CND3
Condensin complex subunit 3

1

0

High-throughput

0.232

Low

683336

SMG9
Nonsense-mediated mRNA decay factor SMG9

1

0

High-throughput

0.232

Low

683347

DIAP3
Protein diaphanous homolog 3

1

0

High-throughput

0.232

Low

683354

SACS
Sacsin

1

0

High-throughput

0.232

Low

683360

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025