HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: MK07 (Q13164)
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
Gene: MAPK7

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	17018293
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 816
+	Hs
		345341 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		MK01_HUMAN (31-390): 1.25e-144: 431: 48.33
+	Hs
		345336 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		MK03_HUMAN (28-390): 3.92e-142: 426: 47.93
+	Dm
		599211 FOSLA_DROME (33-379): 5.55e-44: 164: 19.66		ERKA_DROME (23-393): 1.33e-142: 427: 46.90
+	Hs
		579344 ATF6A_HUMAN (4-318): 1.09e-31: 128: 14.03		MK14_HUMAN (32-388): 1.01e-150: 447: 44.26
+	Hs
		547811 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK14_HUMAN (32-388): 1.01e-150: 447: 44.26
+	Mm
		562973 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK14_MOUSE (32-388): 2.42e-151: 449: 44.26
+	Hs
		547713 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK01_HUMAN (31-390): 1.25e-144: 431: 48.33
+	Hs
		402080 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MK14_HUMAN (32-388): 1.01e-150: 447: 44.26
+	Mm
		562975 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK01_MOUSE (41-390): 1.42e-144: 431: 49.43
+	Hs
		547709 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK03_HUMAN (28-390): 3.92e-142: 426: 47.93
+	Rn
		102456 ATF2_RAT (4-293): 3.18e-29: 119: 18.62		G3V617_RAT (32-400): 4.37e-142: 425: 42.82
+	Mm
		562980 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		MK03_MOUSE (28-390): 1.17e-141: 425: 47.66
+	Hs
		647549 CREM_HUMAN (2-188): 4.21e-26: 109: 18.85		MK03_HUMAN (28-390): 3.92e-142: 426: 47.93
+	Hs
		401473 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MK01_HUMAN (31-390): 1.25e-144: 431: 48.33
+	Hs
		401456 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MK03_HUMAN (28-390): 3.92e-142: 426: 47.93
+	Hs
		568066 JUND_HUMAN (112-215): 1.79e-13: 72.8: 20.00		MK01_HUMAN (31-390): 1.25e-144: 431: 48.33
+	Hs
		547805 ATF2_HUMAN (4-283): 3.58e-29: 119: 18.57		MK11_HUMAN (49-388): 8.63e-99: 313: 47.35