Protein: TCOF
Treacle protein (Treacher Collins syndrome protein)

Gene: TCOF, TCOF1
Organism: Homo sapiens
Interactions: 209
UniProt ID: Q13428

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001650 - fibrillar center
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

827191

ARRB1
Beta-arrestin-1

5

4

Small-scale

0.716

High

685935

ARRB2
Beta-arrestin-2

4

4

Small-scale

0.691

High

1034095

KBTB8
Kelch repeat and BTB domain-containing protein 8

3

3

Small-scale

0.688

High

934143

CSK21
Casein kinase II subunit alpha

3

13

Small-scale

0.674

High

586726

CSK22
Casein kinase II subunit alpha'

3

11

Small-scale

0.667

High

1034126

DEN2D
DENN domain-containing protein 2D

3

1

High-throughput

0.667

High

942635

SRPK2
SRSF protein kinase 2

2

15

High-throughput

0.643

High

133472

NOP56
Nucleolar protein 56

3

2

Small-scale

0.640

High

817660

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

2

High-throughput

0.628

High

1034092

CAMKV
CaM kinase-like vesicle-associated protein

3

3

High-throughput

0.616

High

246221

NBN
Nibrin

1

1

Small-scale

0.604

High

244391

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

268071

EED
Polycomb protein EED

2

20

High-throughput

0.584

High

346709

MYC
Myc proto-oncogene protein

2

18

High-throughput

0.584

High

552648

RFA2
Replication protein A 32 kDa subunit

2

9

High-throughput

0.584

High

651123

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

9

High-throughput

0.584

High

720385

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.584

High

917219

H4
Histone H4

2

10

High-throughput

0.584

High

1034052

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

5

High-throughput

0.584

High

1034053

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

11

Small-scale

0.584

High

1034089

SIR6
NAD-dependent protein deacylase sirtuin-6

2

8

Small-scale

0.584

High

1034121

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

2

20

High-throughput

0.584

High

1034128

ECT2
Protein ECT2

2

11

High-throughput

0.584

High

899628

FGF12
Fibroblast growth factor 12

2

1

Small-scale

0.574

High

272554

OFD1
Centriole and centriolar satellite protein OFD1

2

18

High-throughput

0.571

High

1034050

BECN1
Beclin-1

2

1

High-throughput

0.571

High

277412

RASF9
Ras association domain-containing protein 9

1

2

High-throughput

0.536

High

508506

TOP1
DNA topoisomerase 1

1

3

Small-scale

0.536

High

529074

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.536

High

625411

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.536

High

796564

KSYK
Tyrosine-protein kinase SYK

1

20

High-throughput

0.536

High

801121

KI67
Proliferation marker protein Ki-67

1

19

High-throughput

0.536

High

983601

FAK1
Focal adhesion kinase 1

1

20

High-throughput

0.536

High

984824

RN5A
2-5A-dependent ribonuclease

1

14

High-throughput

0.536

High

996559

ITK
Tyrosine-protein kinase ITK/TSK

1

13

High-throughput

0.536

High

1034057

RASA2
Ras GTPase-activating protein 2

1

11

High-throughput

0.536

High

1034079

PXK
PX domain-containing protein kinase-like protein

1

7

High-throughput

0.536

High

1034084

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.536

High

1034087

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

1034115

PLCD4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

1

3

High-throughput

0.536

High

403214

LA
Lupus La protein

1

7

High-throughput

0.515

High

488707

ARAF
Serine/threonine-protein kinase A-Raf

1

11

High-throughput

0.515

High

779360

CCNF
Cyclin-F

1

4

High-throughput

0.515

High

988858

FMR1
Fragile X messenger ribonucleoprotein 1

1

14

High-throughput

0.515

High

1034059

SF3A1
Splicing factor 3A subunit 1

1

12

High-throughput

0.515

High

1034063

RHG44
Rho GTPase-activating protein 44

1

10

High-throughput

0.515

High

1034072

OBSCN
Obscurin

1

13

High-throughput

0.515

High

1034094

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.515

High

1034098

WDR48
WD repeat-containing protein 48

1

18

High-throughput

0.515

High

1034103

NOC3L
Nucleolar complex protein 3 homolog

1

2

High-throughput

0.515

High

1034124

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

1

6

High-throughput

0.515

High

1034135

DJC17
DnaJ homolog subfamily C member 17

1

12

High-throughput

0.515

High

443494

VIME
Vimentin

1

18

High-throughput

0.515

High

1034101

NEK7
Serine/threonine-protein kinase Nek7

1

18

High-throughput

0.515

High

1034080

LYRIC
Protein LYRIC

1

0

High-throughput

0.513

High

1034113

SORT
Sortilin

1

0

High-throughput

0.513

High

475715

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

12

High-throughput

0.501

High

802587

CRK
Adapter molecule crk

1

13

High-throughput

0.501

High

369542

ESR1
Estrogen receptor

1

20

High-throughput

0.500

High

1034110

ZN462
Zinc finger protein 462

1

0

High-throughput

0.493

High

739967

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

571122

EGLN
Endoglin

1

1

High-throughput

0.489

High

1034123

NUAK2
NUAK family SNF1-like kinase 2

1

1

High-throughput

0.489

High

214254

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.481

High

117397

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

122732

MEN1
Menin

1

3

High-throughput

0.479

High

125432

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

10

High-throughput

0.479

High

148767

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

162707

XPO1
Exportin-1

1

5

High-throughput

0.479

High

179625

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

12

High-throughput

0.479

High

182735

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

227366

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.479

High

232862

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

9

High-throughput

0.479

High

255747

OBSL1
Obscurin-like protein 1

1

14

High-throughput

0.479

High

269721

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

19

High-throughput

0.479

High

294801

RECQ4
ATP-dependent DNA helicase Q4

1

14

High-throughput

0.479

High

303213

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

317109

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

3

Small-scale

0.479

High

323410

TTC4
Tetratricopeptide repeat protein 4

1

16

High-throughput

0.479

High

331806

NSD2
Histone-lysine N-methyltransferase NSD2

1

18

Small-scale

0.479

High

374179

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

10

High-throughput

0.479

High

379368

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

432688

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

High-throughput

0.479

High

489029

H14
Histone H1.4

1

11

High-throughput

0.479

High

559689

H12
Histone H1.2

1

11

High-throughput

0.479

High

569688

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

590897

BTF3
Transcription factor BTF3

1

4

High-throughput

0.479

High

603486

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

652845

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

681829

AKT1
RAC-alpha serine/threonine-protein kinase

1

4

High-throughput

0.479

High

714525

GRK5
G protein-coupled receptor kinase 5

1

6

High-throughput

0.479

High

727517

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

749458

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

781360

BCL6
B-cell lymphoma 6 protein

1

2

High-throughput

0.479

High

801870

RECQ1
ATP-dependent DNA helicase Q1

1

11

High-throughput

0.479

High

803519

BAG6
Large proline-rich protein BAG6

1

20

High-throughput

0.479

High

808576

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

823973

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

20

High-throughput

0.479

High

830739

ARL4D
ADP-ribosylation factor-like protein 4D

1

5

High-throughput

0.479

High

841704

CDK9
Cyclin-dependent kinase 9

1

12

High-throughput

0.479

High

886099

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.479

High

908491

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

7

High-throughput

0.479

High

922152

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

932140

ACTC
Actin, alpha cardiac muscle 1

1

15

High-throughput

0.479

High

934732

H31
Histone H3.1

1

18

High-throughput

0.479

High

940860

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

944768

RED1
Double-stranded RNA-specific editase 1

1

16

High-throughput

0.479

High

949460

RL24
Large ribosomal subunit protein eL24

1

1

High-throughput

0.479

High

959393

VIGLN
Vigilin

1

10

High-throughput

0.479

High

1016164

FOXO1
Forkhead box protein O1

1

14

High-throughput

0.479

High

1026397

RFA4
Replication protein A 30 kDa subunit

1

9

High-throughput

0.479

High

1026977

CBX3
Chromobox protein homolog 3

1

6

High-throughput

0.479

High

1034046

BIRC3
Baculoviral IAP repeat-containing protein 3

1

7

High-throughput

0.479

High

1034047

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.479

High

1034048

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.479

High

1034049

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.479

High

1034051

NBR1
Next to BRCA1 gene 1 protein

1

2

High-throughput

0.479

High

1034054

CUL7
Cullin-7

1

8

High-throughput

0.479

High

1034055

TNIP1
TNFAIP3-interacting protein 1

1

16

High-throughput

0.479

High

1034056

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1034058

RBBP5
Retinoblastoma-binding protein 5

1

20

High-throughput

0.479

High

1034060

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

1034061

TRBP2
RISC-loading complex subunit TARBP2

1

19

High-throughput

0.479

High

1034062

RBBP7
Histone-binding protein RBBP7

1

10

High-throughput

0.479

High

1034065

LARP7
La-related protein 7

1

9

High-throughput

0.479

High

1034067

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

1034070

DCA12
DDB1- and CUL4-associated factor 12

1

1

High-throughput

0.479

High

1034074

VIR
Protein virilizer homolog

1

5

High-throughput

0.479

High

1034076

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

1034081

ZN598
E3 ubiquitin-protein ligase ZNF598

1

12

High-throughput

0.479

High

1034082

NAA40
N-alpha-acetyltransferase 40

1

8

High-throughput

0.479

High

1034083

ZCH18
Zinc finger CCCH domain-containing protein 18

1

16

High-throughput

0.479

High

1034090

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

High-throughput

0.479

High

1034091

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

1034097

SNIP1
Smad nuclear-interacting protein 1

1

3

High-throughput

0.479

High

1034099

RIN3
Ras and Rab interactor 3

1

8

High-throughput

0.479

High

1034102

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

1034104

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1034105

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1034108

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1034109

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1034111

NEB2
Neurabin-2

1

20

High-throughput

0.479

High

1034114

H2B1L
Histone H2B type 1-L

1

20

High-throughput

0.479

High

1034116

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

1034118

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.479

High

1034120

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

6

High-throughput

0.479

High

1034122

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

1

High-throughput

0.479

High

1034125

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

1034127

BRD9
Bromodomain-containing protein 9

1

20

High-throughput

0.479

High

1034129

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

1

Small-scale

0.479

High

1034130

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.479

High

1034131

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

10

High-throughput

0.479

High

1034134

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

1034136

NLE1
Notchless protein homolog 1

1

10

High-throughput

0.479

High

1034137

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1034138

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

Small-scale

0.479

High

1034139

PI4KB
Phosphatidylinositol 4-kinase beta

1

3

Small-scale

0.479

High

1034140

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

1034141

TBK1
Serine/threonine-protein kinase TBK1

1

10

High-throughput

0.479

High

1034143

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.479

High

1034144

PRP19
Pre-mRNA-processing factor 19

1

14

High-throughput

0.479

High

1034145

CC14A
Dual specificity protein phosphatase CDC14A

1

5

High-throughput

0.479

High

1034146

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.479

High

1034147

NOP58
Nucleolar protein 58

1

2

Small-scale

0.479

High

1034149

TRRAP
Transformation/transcription domain-associated protein

1

10

High-throughput

0.479

High

1034150

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.479

High

990780

COGA1

1

4

High-throughput

0.470

High

1034086

CA2D3
Voltage-dependent calcium channel subunit alpha-2/delta-3

1

1

High-throughput

0.470

High

557457

PECA1
Platelet endothelial cell adhesion molecule

1

15

High-throughput

0.470

High

987504

APLP2
Amyloid beta precursor like protein 2

1

3

High-throughput

0.470

High

242450

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

0

Small-scale

0.458

High

931621

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.458

High

1034068

MIDN
Midnolin

1

0

High-throughput

0.458

High

1034112

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.458

High

1034132

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

48658

MED19
Mediator of RNA polymerase II transcription subunit 19

1

1

High-throughput

0.445

High

401947

JUN
Transcription factor Jun

1

13

High-throughput

0.445

High

1034069

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

1034075

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

1034085

SLX4
Structure-specific endonuclease subunit SLX4

1

20

High-throughput

0.445

High

1034106

ESR2
Estrogen receptor beta

1

20

High-throughput

0.445

High

1034148

SHLB1
Endophilin-B1

1

16

High-throughput

0.445

High

242087

PAGE4
P antigen family member 4

1

1

High-throughput

0.437

High

282896

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

20

High-throughput

0.437

High

338376

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.437

High

352605

TNFA
Tumor necrosis factor

1

1

High-throughput

0.437

High

384785

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

400064

ICAM1
Intercellular adhesion molecule 1

1

4

High-throughput

0.437

High

1034066

Q4LE69
1-phosphatidylinositol 4-kinase

1

3

Small-scale

0.437

High

1034073

DCA15
DDB1- and CUL4-associated factor 15

1

3

High-throughput

0.437

High

1034078

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1034096

RASF8
Ras association domain-containing protein 8

1

2

High-throughput

0.437

High

1034100

TIP
T-cell immunomodulatory protein

1

3

High-throughput

0.437

High

1034107

IGSF8
Immunoglobulin superfamily member 8

1

10

High-throughput

0.437

High

1034117

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

3

High-throughput

0.437

High

1034119

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.437

High

175566

TM9S1
Transmembrane 9 superfamily member 1

1

0

High-throughput

0.282

High

878127

PKNX1
Homeobox protein PKNOX1

1

0

High-throughput

0.282

High

1034071

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.279

Low

63965

VTM2B
V-set and transmembrane domain-containing protein 2B

1

0

High-throughput

0.269

Low

473060

BNIP5
Protein BNIP5

1

0

High-throughput

0.269

Low

940622

F193A
Protein FAM193A

1

0

High-throughput

0.269

Low

1034133

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.269

Low

547553

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

1034064

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1034077

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1034088

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

1034142

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low

1034093

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024