HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: COP1 (Q8NHY2)
E3 ubiquitin-protein ligase COP1 (EC 2.3.2.27) (Constitutive photomorphogenesis protein 1 homolog) (hCOP1) (RING finger and WD repeat domain protein 2) (RING finger protein 200) (RING-type E3 ubiquitin transferase RFWD2)
Gene: COP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.737

Property	Details
Experiments	26186194, 26496610, 25609649, 28514442, 33961781, 35140242
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 731
+	Hs
		548256 FOSL1_HUMAN (59-287): 1.43e-34: 130: 37.61		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		579360 ATF6A_HUMAN (4-318): 1.09e-31: 128: 14.03		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		548320 FOSL2_HUMAN (2-380): 3.19e-31: 122: 39.54		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		862626 FOSB_HUMAN (2-380): 1.59e-25: 107: 34.24		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		566776 JUNB_HUMAN (85-215): 3.19e-25: 106: 19.86		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		402265 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		579219 ATF3_HUMAN (131-215): 4.23e-25: 102: 43.53		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		568100 JUND_HUMAN (112-215): 1.79e-13: 72.8: 20.00		COP1_HUMAN (1-731): 0: 540: 100.00
+	Hs
		402320 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		FBXW7_HUMAN (452-730): 4.46e-69: 242: 17.15
+	Hs
		196941 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		PRP4_HUMAN (511-730): 7.51e-41: 159: 16.59
+	Hs
		402538 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		NLE1_HUMAN (582-729): 3.62e-35: 141: 15.33
+	Hs
		401900 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		RBBP4_HUMAN (512-702): 3.22e-20: 96: 14.49
+	Hs
		401754 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		WDR5_HUMAN (632-730): 5.38e-16: 81.8: 18.18
+	Hs
		402083 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		RBBP7_HUMAN (476-629): 3.89e-12: 70.9: 29.34
+	Hs
		402335 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		SNR40_HUMAN (307-447): 5.3e-10: 63.7: 12.67