HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25609649, 35140242
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0007399 - nervous system development GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 1214
+	Hs
		345510 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		402268 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		402312 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		345592 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		345491 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57
+	Hs
		1317574 BACH2_HUMAN (14-307): 4.1e-34: 136: 13.65		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		231964 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		232187 BATF_HUMAN (132-233): 4.1e-25: 100: 30.39		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		261583 BACH2_HUMAN (14-307): 4.1e-34: 136: 13.65		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		157162 BACH1_HUMAN (4-295): 1.68e-30: 125: 12.99		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Mm
		956178 BACH1_MOUSE (4-304): 5.82e-27: 114: 14.16		NCOR1_MOUSE (597-1189): 5.86e-31: 135: 11.95
+	Hs
		402682 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Mm
		70890 ATF2_MOUSE (4-293): 1.84e-28: 117: 18.62		EP300_MOUSE (885-1214): 8.74e-09: 62.4: 13.78
+	Hs
		401691 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		SC24C_HUMAN (1005-1213): 5.27e-13: 75.8: 19.28
+	Hs
		402260 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57