HitPredict

Interactor 1: FOS (P01100)
Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Gene: FOS

Interactor 2: CIC (Q96RK0)
Protein capicua homolog
Gene: CIC

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 380 Hs			1 2517
+	Hs
		568277 ATF7_HUMAN (82-289): 7.9e-31: 124: 16.59		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		973616 CREB5_HUMAN (92-233): 1.13e-24: 107: 19.01		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		402371 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		CIC_HUMAN (1-2517): 0: 961: 100.00
+	Hs
		345592 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		579320 ATF6A_HUMAN (4-318): 1.09e-31: 128: 14.03		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		345491 FOS_HUMAN (1-380): 1.68e-84: 263: 100.00		KMT2C_HUMAN (1873-2516): 1.5e-09: 66.4: 10.57
+	Hs
		157187 BACH1_HUMAN (4-295): 1.68e-30: 125: 12.99		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		401617 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Ce
		105502 JUN_CAEEL (50-205): 2.19e-28: 114: 22.64		EGL13_CAEEL (1033-1238): 1.27e-41: 163: 20.00
+	Hs
		568076 JUND_HUMAN (112-215): 1.79e-13: 72.8: 20.00		SOX2_HUMAN (1073-1308): 2.83e-57: 204: 24.05
+	Hs
		818823 CR3L4_HUMAN (2-295): 5.76e-41: 150: 16.34		SOX9_HUMAN (1031-1201): 1.04e-24: 112: 23.08
+	Hs
		401362 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MUC1_HUMAN (290-979): 5.97e-38: 159: 15.12
+	Hs
		1317574 BACH2_HUMAN (14-307): 4.1e-34: 136: 13.65		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		402007 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MDC1_HUMAN (1380-2408): 4.76e-21: 104: 10.30
+	Hs
		402682 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		NCOR2_HUMAN (290-1816): 8.11e-14: 80.2: 8.06
+	Hs
		402260 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		KMT2C_HUMAN (1873-2516): 1.5e-09: 66.4: 10.57
+	Hs
		401830 JUN_HUMAN (48-215): 1.19e-23: 102: 16.47		MAP1A_HUMAN (763-2517): 4.52e-09: 64.4: 8.00