Protein: CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Gene: CLPX
Organism: Homo sapiens
Interactions: 184
UniProt ID: O76031

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282080

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

5

2

Small-scale

0.912

High

282166

FBW1B
F-box/WD repeat-containing protein 11

4

1

High-throughput

0.683

High

282169

FBW1A
F-box/WD repeat-containing protein 1A

3

1

High-throughput

0.671

High

282103

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

3

1

High-throughput

0.667

High

282129

THTPA
Thiamine-triphosphatase

3

0

High-throughput

0.638

High

282137

NDEL1
Nuclear distribution protein nudE-like 1

2

1

High-throughput

0.628

High

282032

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.618

High

282013

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.616

High

282098

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.602

High

282112

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

0

High-throughput

0.602

High

59070

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.586

High

282028

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

Small-scale

0.585

High

282073

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

282096

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

2

0

High-throughput

0.585

High

282153

EXD2
Exonuclease 3'-5' domain-containing protein 2

2

0

High-throughput

0.576

High

282027

GNS
N-acetylglucosamine-6-sulfatase

2

1

High-throughput

0.574

High

282054

H31
Histone H3.1

2

1

High-throughput

0.571

High

226096

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

262656

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

282014

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

2

0

High-throughput

0.559

High

282026

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

282060

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.559

High

282029

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.547

High

282068

CUL1
Cullin-1

1

2

High-throughput

0.536

High

282070

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

282087

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

282094

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.536

High

282100

DDX54
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.536

High

282089

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

282041

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.513

High

282043

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

282053

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

282066

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

282079

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

282099

ALAT2
Alanine aminotransferase 2

1

0

High-throughput

0.513

High

282110

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.513

High

282141

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

282142

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.513

High

282158

TRM1
tRNA

1

0

High-throughput

0.513

High

282160

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.513

High

282164

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

282165

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

282171

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

282011

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

282157

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.493

High

270856

CLC3A
C-type lectin domain family 3 member A

1

2

High-throughput

0.489

High

174496

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

282050

NKX25
Homeobox protein Nkx-2.5

1

0

High-throughput

0.479

High

282058

HEN1
Helix-loop-helix protein 1

1

0

High-throughput

0.479

High

264798

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

266594

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

269957

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

270901

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.479

High

282016

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

282033

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

282034

GRP75
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

282037

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

282040

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

282046

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.479

High

282051

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

282055

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

282062

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

282064

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

282069

CUL3
Cullin-3

1

2

High-throughput

0.479

High

282075

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

282092

H32
Histone H3.2

1

1

High-throughput

0.479

High

282093

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

282095

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

282106

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

282107

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

282116

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

282121

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

282124

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

282139

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

282144

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

282162

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

282170

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.479

High

282175

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.479

High

282161

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

148232

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

172949

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

177758

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

258378

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

276765

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

282017

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

282018

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

282019

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

282020

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

282021

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

282022

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

282023

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

282024

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

282025

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

282030

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

282031

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

282035

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

282036

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

282039

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

282042

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

282045

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

282047

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

282048

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

282049

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

282052

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

282057

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

282059

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

282061

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

282063

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

282065

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

282067

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

282072

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

282076

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

282077

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

282078

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

282081

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

282082

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

282084

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

282086

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

282088

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

282090

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

282101

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

282104

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

282105

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

282109

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

282111

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

282114

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

282115

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

282117

KIF12
Kinesin-like protein KIF12

1

0

High-throughput

0.458

High

282118

FMC1
Protein FMC1 homolog

1

0

High-throughput

0.458

High

282119

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

282120

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

282122

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

282123

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

282125

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

282126

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.458

High

282127

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

282128

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

282131

TR61B
tRNA

1

0

High-throughput

0.458

High

282133

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

282135

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

282138

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

282140

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

282143

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

282145

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

282147

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

282148

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

282149

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

282150

NGRN
Neugrin

1

0

High-throughput

0.458

High

282151

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

282152

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

282154

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

282155

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

282156

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

282159

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

282163

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

282168

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

282172

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

282173

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

282134

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.457

High

282074

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

Small-scale

0.445

High

282174

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

282102

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

282146

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

282167

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

866

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

282085

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

282136

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

277553

DHRS3
Short-chain dehydrogenase/reductase 3

1

0

High-throughput

0.279

Low

282108

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

282132

LS14B
Protein LSM14 homolog B

1

0

High-throughput

0.279

Low

282130

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.269

Low

169339

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

260502

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.249

Low

282010

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

282012

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

282015

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

282038

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.249

Low

282044

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.249

Low

282056

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

282071

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

282083

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

282091

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.249

Low

282097

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

282113

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024