HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: LMNA (P02545)
Prelamin-A/C [Cleaved into: Lamin-A/C (70 kDa lamin) (Renal carcinoma antigen NY-REN-32)]
Gene: LMNA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	29467282, 35013218, 36424410, 17314511, 21150319
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010628 - positive regulation of gene expression GO:0032204 - regulation of telomere maintenance GO:0071456 - cellular response to hypoxia
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 664
+	Hs
		345816 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		345637 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		345660 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		K2C6B_HUMAN (24-407): 5.03e-115: 357: 23.51
+	Hs
		378970 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		K2C5_HUMAN (24-390): 2.24e-117: 364: 25.95
+	Hs
		359449 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		K2C6A_HUMAN (23-407): 5.26e-116: 360: 23.71
+	Hs
		346579 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LMNB2_HUMAN (21-580): 7.45e-51: 188: 52.68
+	Hs
		345912 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		347231 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		K2C73_HUMAN (23-390): 1.74e-50: 185: 23.85
+	Hs
		345739 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		359555 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		359716 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		LMNA_HUMAN (1-664): 7.64e-79: 265: 100.00
+	Hs
		379010 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37
+	Hs
		378927 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		VIME_HUMAN (27-389): 3.94e-31: 129: 28.93
+	Hs
		378972 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		GFAP_HUMAN (27-427): 1.12e-28: 121: 27.43
+	Hs
		595120 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		LMNB1_HUMAN (21-580): 5.16e-50: 185: 54.37