HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: RING1 (Q06587)
E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein)
Gene: RING1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	29467282, 30415952, 36708875
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 406
+	Hs
		347679 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		379317 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		347835 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TRIM6_HUMAN (39-392): 1.17e-47: 171: 12.53
+	Hs
		345897 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		347818 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		347755 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		346112 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		379766 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		987987 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		983423 MAD1_HUMAN (320-453): 2.08e-29: 116: 19.40		RING1_HUMAN (1-406): 2.01e-114: 342: 100.00
+	Hs
		1218708 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		RING2_HUMAN (8-406): 4.9e-100: 302: 54.25
+	Hs
		379067 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		717992 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		BMI1_HUMAN (31-378): 4.06e-63: 207: 14.16
+	Hs
		584889 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		RO52_HUMAN (33-392): 4.67e-43: 158: 13.14
+	Hs
		749531 USF2_HUMAN (180-454): 1.78e-35: 136: 15.99		BRCA1_HUMAN (33-361): 4.24e-35: 139: 15.63
+	Hs
		718407 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		PCGF2_HUMAN (31-377): 1.44e-41: 151: 14.37
+	Hs
		1218718 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		PCGF6_HUMAN (31-157): 1.02e-40: 149: 23.08
+	Hs
		1218715 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		PCGF1_HUMAN (25-133): 3.54e-40: 145: 25.00
+	Hs
		1108514 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		PCGF3_HUMAN (34-224): 6.2e-39: 141: 17.53
+	Hs
		1197567 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		PCGF5_HUMAN (31-147): 4.96e-38: 139: 23.33