Protein: TTC4
Tetratricopeptide repeat protein 4 (TPR repeat protein 4)

Gene: TTC4
Organism: Homo sapiens
Interactions: 134
UniProt ID: O95801

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0030544 - Hsp70 protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346640

EDRF1
Erythroid differentiation-related factor 1

5

1

High-throughput

0.716

High

346593

HS90A
Heat shock protein HSP 90-alpha

4

20

Small-scale

0.691

High

346658

GCC2
GRIP and coiled-coil domain-containing protein 2

4

14

High-throughput

0.691

High

346595

HS90B
Heat shock protein HSP 90-beta

3

20

Small-scale

0.677

High

346697

SPB13
Serpin B13

3

6

High-throughput

0.662

High

346682

HGH1
Protein HGH1 homolog

5

4

High-throughput

0.652

High

346695

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

10

High-throughput

0.628

High

346635

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

2

20

High-throughput

0.611

High

346700

S27A6
Long-chain fatty acid transport protein 6

3

17

High-throughput

0.604

High

346672

SNPC3
snRNA-activating protein complex subunit 3

2

0

High-throughput

0.580

High

346678

NOX5
NADPH oxidase 5

2

2

High-throughput

0.574

High

336812

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

6

High-throughput

0.536

High

346590

S10A9
Protein S100-A9

1

9

High-throughput

0.536

High

346597

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

6

High-throughput

0.536

High

346613

GRK6
G protein-coupled receptor kinase 6

1

20

High-throughput

0.536

High

346631

SRSF2
Serine/arginine-rich splicing factor 2

1

8

High-throughput

0.536

High

346638

TEBP
Prostaglandin E synthase 3

1

14

High-throughput

0.536

High

346639

CDC37
Hsp90 co-chaperone Cdc37

1

15

High-throughput

0.536

High

346650

ACD11
Acyl-CoA dehydrogenase family member 11

1

1

High-throughput

0.536

High

346652

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

14

High-throughput

0.536

High

346687

E41L5
Band 4.1-like protein 5

1

8

High-throughput

0.536

High

346601

HSP7C
Heat shock cognate 71 kDa protein

1

20

Small-scale

0.526

High

346680

CDC6
Cell division control protein 6 homolog

1

2

Small-scale

0.526

High

346659

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

346699

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.513

High

185324

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

18

High-throughput

0.501

High

346696

TBK1
Serine/threonine-protein kinase TBK1

1

20

Small-scale

0.500

High

346665

RL3R2
Relaxin-3 receptor 2

1

2

High-throughput

0.494

High

346598

GIP
Gastric inhibitory polypeptide

1

2

High-throughput

0.489

High

346616

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.489

High

346683

BTBD2
BTB/POZ domain-containing protein 2

1

5

High-throughput

0.489

High

346692

TMOD4
Tropomodulin-4

1

4

High-throughput

0.489

High

169874

AURKA
Aurora kinase A

1

20

High-throughput

0.479

High

240398

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.479

High

273322

NPHP4
Nephrocystin-4

1

3

High-throughput

0.479

High

279258

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

292992

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.479

High

314988

RECQ4
ATP-dependent DNA helicase Q4

1

16

High-throughput

0.479

High

346586

P53
Cellular tumor antigen p53

1

10

High-throughput

0.479

High

346589

LCK
Tyrosine-protein kinase Lck

1

16

High-throughput

0.479

High

346608

CEBPB
CCAAT/enhancer-binding protein beta

1

12

High-throughput

0.479

High

346619

LMAN1
Protein ERGIC-53

1

6

High-throughput

0.479

High

346622

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

346623

ACTZ
Alpha-centractin

1

12

High-throughput

0.479

High

346624

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

17

High-throughput

0.479

High

346625

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

346627

TBA4A
Tubulin alpha-4A chain

1

19

High-throughput

0.479

High

346632

TLE2
Transducin-like enhancer protein 2

1

20

High-throughput

0.479

High

346633

EP300
Histone acetyltransferase p300

1

13

High-throughput

0.479

High

346634

TCOF
Treacle protein

1

12

High-throughput

0.479

High

346636

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

346637

HAPR1
HUWE1-associated protein modifying stress responses 1

1

2

High-throughput

0.479

High

346641

GLE1
mRNA export factor GLE1

1

8

High-throughput

0.479

High

346643

DCAF6
DDB1- and CUL4-associated factor 6

1

20

High-throughput

0.479

High

346648

WDR82
WD repeat-containing protein 82

1

20

High-throughput

0.479

High

346649

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

346651

TBA1A
Tubulin alpha-1A chain

1

20

High-throughput

0.479

High

346653

DET1
DET1 homolog

1

7

High-throughput

0.479

High

346654

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

16

High-throughput

0.479

High

346655

NEK8
Serine/threonine-protein kinase Nek8

1

20

High-throughput

0.479

High

346661

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

346666

DCA11
DDB1- and CUL4-associated factor 11

1

15

High-throughput

0.479

High

346668

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

346670

KAT6A
Histone acetyltransferase KAT6A

1

12

Small-scale

0.479

High

346673

FBX32
F-box only protein 32

1

6

High-throughput

0.479

High

346674

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

346677

CI072
Guanine nucleotide exchange factor C9orf72

1

7

High-throughput

0.479

High

346679

RUFY1
RUN and FYVE domain-containing protein 1

1

20

High-throughput

0.479

High

346681

TRI56
E3 ubiquitin-protein ligase TRIM56

1

17

High-throughput

0.479

High

346684

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

20

High-throughput

0.479

High

346685

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

346686

EGLN3
Prolyl hydroxylase EGLN3

1

8

High-throughput

0.479

High

346688

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

346689

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

3

High-throughput

0.479

High

346691

WWOX
WW domain-containing oxidoreductase

1

5

High-throughput

0.479

High

346645

DCA12
DDB1- and CUL4-associated factor 12

1

0

High-throughput

0.458

High

346676

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

67523

MYH7B
Myosin-7B

1

13

High-throughput

0.445

High

117615

K9JA46
Epididymis luminal secretory protein 52

1

20

High-throughput

0.445

High

138430

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.445

High

346581

KAD1
Adenylate kinase isoenzyme 1

1

2

High-throughput

0.445

High

346585

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

2

High-throughput

0.445

High

346587

FABPH
Fatty acid-binding protein, heart

1

2

High-throughput

0.445

High

346599

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

3

High-throughput

0.445

High

346600

MYH3
Myosin-3

1

13

High-throughput

0.445

High

346602

PYGM
Glycogen phosphorylase, muscle form

1

2

High-throughput

0.445

High

346604

MYH7
Myosin-7

1

13

High-throughput

0.445

High

346605

MYH6
Myosin-6

1

13

High-throughput

0.445

High

346612

PGM1
Phosphoglucomutase-1

1

1

High-throughput

0.445

High

346617

TNNI2
Troponin I, fast skeletal muscle

1

1

High-throughput

0.445

High

346642

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

346644

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

High-throughput

0.445

High

346647

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.445

High

346675

MYL11
Myosin regulatory light chain 11

1

3

High-throughput

0.445

High

346698

MYH2
Myosin-2

1

13

High-throughput

0.445

High

326500

MFN2
Mitofusin-2

1

3

High-throughput

0.437

High

346584

RASN
GTPase NRas

1

2

High-throughput

0.437

High

346594

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.437

High

346611

FGFR3
Fibroblast growth factor receptor 3

1

19

High-throughput

0.437

High

346646

OBI1
ORC ubiquitin ligase 1

1

2

High-throughput

0.437

High

346660

FBXL6
F-box/LRR-repeat protein 6

1

13

High-throughput

0.437

High

346663

Q8TA90
Elongation factor 2

1

10

High-throughput

0.437

High

346690

WSB2
WD repeat and SOCS box-containing protein 2

1

16

High-throughput

0.437

High

346693

Q9P0T5
HSPC188

1

4

High-throughput

0.437

High

144123

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

0

High-throughput

0.426

High

346615

GLYG
Glycogenin-1

1

0

High-throughput

0.426

High

346618

RPIA
Ribose-5-phosphate isomerase

1

0

High-throughput

0.426

High

47861

A0AUL9
ATG2A protein

1

10

High-throughput

0.407

High

346582

HPT
Haptoglobin

1

1

High-throughput

0.407

High

346583

ANT3
Antithrombin-III

1

6

High-throughput

0.407

High

346588

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

1

High-throughput

0.407

High

346591

KCRM
Creatine kinase M-type

1

2

High-throughput

0.407

High

346592

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.407

High

346596

ENOG
Gamma-enolase

1

6

High-throughput

0.407

High

346603

MYL4
Myosin light chain 4

1

1

High-throughput

0.407

High

346606

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.407

High

346607

ENOB
Beta-enolase

1

6

High-throughput

0.407

High

346609

TNNI1
Troponin I, slow skeletal muscle

1

1

High-throughput

0.407

High

346610

NEBU
Nebulin

1

10

High-throughput

0.407

High

346614

TNNT3
Troponin T, fast skeletal muscle

1

1

High-throughput

0.407

High

346621

S12A3
Solute carrier family 12 member 3

1

20

High-throughput

0.407

High

346628

HBB
Hemoglobin subunit beta

1

1

High-throughput

0.407

High

346629

HBA
Hemoglobin subunit alpha

1

1

High-throughput

0.407

High

346630

MYPC1
Myosin-binding protein C, slow-type

1

9

High-throughput

0.407

High

346656

Q86SX1
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens

1

20

High-throughput

0.407

High

346657

NNRD
ATP-dependent

1

2

High-throughput

0.407

High

346669

TITIN
Titin

1

11

High-throughput

0.407

High

346671

EDA
Ectodysplasin-A

1

3

High-throughput

0.407

High

346694

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

0

High-throughput

0.269

Low

346664

SUN5
SUN domain-containing protein 5

1

0

High-throughput

0.249

Low

346667

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.249

Low

346620

LUM
Lumican

1

0

High-throughput

0.232

Low

346626

TNNC1
Troponin C, slow skeletal and cardiac muscles

1

0

High-throughput

0.232

Low

346662

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025