HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29467282, 36424410
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 454 Hs			1 2089
+	Hs
		1056883 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		346651 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Hs
		348379 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NCOR2_HUMAN (149-1902): 1.48e-73: 276: 8.36
+	Hs
		346173 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		347455 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		346565 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MUC3A_HUMAN (86-1955): 2.8e-32: 140: 10.32
+	Hs
		347056 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13
+	Hs
		348258 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08
+	Hs
		347505 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRG4_HUMAN (260-1225): 4.33e-17: 90.5: 9.80
+	Hs
		348352 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Hs
		379107 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		347668 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33
+	Hs
		801237 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		379663 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		380026 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		SRRM2_HUMAN (133-1326): 2.15e-19: 98.4: 8.08
+	Hs
		380070 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Hs
		1154048 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13