Protein: ABL2
Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)

Gene: ABL2
Organism: Homo sapiens
Interactions: 120
UniProt ID: P42684

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001784 - phosphotyrosine residue binding
GO:0003785 - actin monomer binding
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

840932

CRK
Adapter molecule crk

7

20

Small-scale

0.968

High

840988

ABI2
Abl interactor 2

4

20

High-throughput

0.902

High

222027

NCK2
Cytoplasmic protein NCK2

4

20

High-throughput

0.892

High

362926

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.887

High

362199

ABL1
Tyrosine-protein kinase ABL1

3

19

Small-scale

0.858

High

410691

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

20

Small-scale

0.858

High

840962

CIP4
Cdc42-interacting protein 4

3

7

Small-scale

0.853

High

593935

NCK1
SH2/SH3 adapter protein NCK1

3

20

High-throughput

0.839

High

840943

GRB2
Growth factor receptor-bound protein 2

3

19

Small-scale

0.834

High

840963

CDC37
Hsp90 co-chaperone Cdc37

2

13

High-throughput

0.811

High

641513

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

840931

ABL2
Tyrosine-protein kinase ABL2

2

19

Small-scale

0.778

High

840959

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

19

High-throughput

0.778

High

250219

VINEX
Vinexin

2

20

High-throughput

0.776

High

827692

STAT3
Signal transducer and activator of transcription 3

2

15

High-throughput

0.767

High

840975

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

19

High-throughput

0.767

High

710789

EPHB2
Ephrin type-B receptor 2

2

20

Small-scale

0.757

High

840945

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.754

High

840993

ALK
ALK tyrosine kinase receptor

2

20

High-throughput

0.754

High

619003

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

16

High-throughput

0.747

High

840938

EPHA4
Ephrin type-A receptor 4

2

20

High-throughput

0.743

High

786979

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.724

High

840956

RIN1
Ras and Rab interactor 1

5

20

Small-scale

0.720

High

374448

RASH
GTPase HRas

1

19

Small-scale

0.715

High

840951

1433F
14-3-3 protein eta

1

20

High-throughput

0.715

High

536675

HSP7C
Heat shock cognate 71 kDa protein

5

11

High-throughput

0.709

High

320220

SRBS2
Sorbin and SH3 domain-containing protein 2

1

20

Small-scale

0.709

High

473378

HCK
Tyrosine-protein kinase HCK

1

19

High-throughput

0.698

High

840948

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

17

High-throughput

0.698

High

472019

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532058

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

461244

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.691

High

468152

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.691

High

840933

CRKL
Crk-like protein

1

20

High-throughput

0.691

High

840974

IASPP
RelA-associated inhibitor

1

16

High-throughput

0.691

High

840980

BAG1
BAG family molecular chaperone regulator 1

1

1

High-throughput

0.691

High

840992

BAG5
BAG family molecular chaperone regulator 5

4

2

High-throughput

0.691

High

484076

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.647

High

840966

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

16

High-throughput

0.647

High

840970

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

840978

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

12

High-throughput

0.647

High

294838

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

19

High-throughput

0.618

High

375263

RASK
GTPase KRas

1

20

High-throughput

0.618

High

411524

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

440427

FYN
Tyrosine-protein kinase Fyn

1

19

High-throughput

0.618

High

541382

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

557158

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

580912

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

601202

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

648449

FGFR4
Fibroblast growth factor receptor 4

1

20

High-throughput

0.618

High

658653

JAK1
Tyrosine-protein kinase JAK1

1

19

Small-scale

0.618

High

690810

1433T
14-3-3 protein theta

1

20

High-throughput

0.618

High

699630

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

710107

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.618

High

711271

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

720150

UFO
Tyrosine-protein kinase receptor UFO

1

20

Small-scale

0.618

High

729661

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.618

High

730431

1433S
14-3-3 protein sigma

1

20

High-throughput

0.618

High

840937

EPHB4
Ephrin type-B receptor 4

1

20

High-throughput

0.618

High

840939

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

840940

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

840941

1433G
14-3-3 protein gamma

1

20

High-throughput

0.618

High

840942

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.618

High

840944

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

840952

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

20

High-throughput

0.618

High

840957

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

840960

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.618

High

840968

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

840986

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

840994

NCKP1
Nck-associated protein 1

2

2

High-throughput

0.611

High

346889

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.601

High

399945

CATA
Catalase

1

1

Small-scale

0.578

High

451603

GPX1
Glutathione peroxidase 1

1

1

Small-scale

0.578

High

840981

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

20

Small-scale

0.575

High

840982

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

1

13

High-throughput

0.575

High

840987

CASS4
Cas scaffolding protein family member 4

1

20

Small-scale

0.575

High

165280

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.561

High

519814

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

840983

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

6

Small-scale

0.536

High

840936

HSP72
Heat shock-related 70 kDa protein 2

1

11

High-throughput

0.536

High

840954

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.536

High

840955

CUL4A
Cullin-4A

2

3

Small-scale

0.533

High

840979

DOK1
Docking protein 1

1

20

Small-scale

0.527

High

840967

FBX38
F-box only protein 38

1

0

High-throughput

0.518

High

840934

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

12

High-throughput

0.501

High

840949

CAV1
Caveolin-1

1

9

Small-scale

0.501

High

190122

TNC18
Trinucleotide repeat-containing gene 18 protein

1

8

High-throughput

0.479

High

474533

VIME
Vimentin

1

8

High-throughput

0.479

High

642690

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

10

High-throughput

0.479

High

651206

CBL
E3 ubiquitin-protein ligase CBL

1

20

High-throughput

0.479

High

770445

SPRE
Sepiapterin reductase

1

6

High-throughput

0.479

High

832670

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.479

High

840935

PAXI
Paxillin

1

20

High-throughput

0.479

High

840946

VIGLN
Vigilin

1

6

High-throughput

0.479

High

840950

TF65
Transcription factor p65

1

4

High-throughput

0.479

High

840953

BST2
Bone marrow stromal antigen 2

1

1

High-throughput

0.479

High

840958

EEA1
Early endosome antigen 1

1

9

High-throughput

0.479

High

840972

SCAI
Protein SCAI

1

1

High-throughput

0.479

High

840973

BICD2
Protein bicaudal D homolog 2

1

15

High-throughput

0.479

High

840976

BICD1
Protein bicaudal D homolog 1

1

16

High-throughput

0.479

High

840977

SNX27
Sorting nexin-27

1

16

High-throughput

0.479

High

840995

MYO5A
Unconventional myosin-Va

1

4

High-throughput

0.479

High

840985

MED28
Mediator of RNA polymerase II transcription subunit 28

1

8

Small-scale

0.470

High

593733

PECA1
Platelet endothelial cell adhesion molecule

1

18

Small-scale

0.445

High

840971

FXL16
F-box/LRR-repeat protein 16

1

2

High-throughput

0.445

High

840990

SLAF5
SLAM family member 5

1

14

Small-scale

0.445

High

840965

ZMAT1
Zinc finger matrin-type protein 1

1

1

High-throughput

0.439

High

840969

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

840991

TF3C4
General transcription factor 3C polypeptide 4

1

2

High-throughput

0.437

High

350314

G6B
Megakaryocyte and platelet inhibitory receptor G6b

1

0

Small-scale

0.426

High

840961

SF01
Splicing factor 1

1

20

High-throughput

0.417

High

840947

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.408

High

186246

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.292

High

217068

MS18B
Protein Mis18-beta

1

0

High-throughput

0.282

High

840964

TPD53
Tumor protein D53

1

0

High-throughput

0.282

High

840984

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.282

High

840989

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

63747

KRBA1
Protein KRBA1

1

0

High-throughput

0.232

Low

296690

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025