HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: FBXW8 (Q8N3Y1)
F-box/WD repeat-containing protein 8 (F-box and WD-40 domain-containing protein 8) (F-box only protein 29)
Gene: FBXW8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.50	0.542

Property	Details
Experiments	17314511
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 598
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (285-590): 4.32e-82: 273: 13.88
+	Hs
		348035 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NLE1_HUMAN (374-598): 6.99e-46: 170: 10.26
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (6-327): 3.89e-44: 164: 11.60
+	Hs
		348277 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		346638 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		TBL3_HUMAN (73-236): 2.09e-15: 81.8: 15.48
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (285-590): 4.32e-82: 273: 13.88
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (285-590): 4.32e-82: 273: 13.88
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (285-590): 1.43e-81: 272: 13.88
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Hs
		252937 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		252935 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Hs
		840229 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		FBW1A_HUMAN (421-593): 2.84e-31: 130: 17.22
+	Hs
		840227 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		FBW1B_HUMAN (421-593): 2.42e-30: 127: 18.33
+	Dm
		1375911 MYC_DROME (210-454): 3.25e-30: 126: 26.74		FBXW7_DROME (460-598): 3.83e-25: 113: 17.01
+	Hs
		903353 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		WDR5_HUMAN (463-590): 7.6e-28: 116: 12.69
+	Mm
		659344 MAX_MOUSE (354-454): 3.52e-25: 102: 32.67		WDR5_MOUSE (463-590): 7.6e-28: 116: 12.69