Protein: DAPK1
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)

Gene: DAPK1
Organism: Homo sapiens
Interactions: 208
UniProt ID: P53355

Gene Ontology (top 5):
GO:0002357 - defense response to tumor cell
GO:0002834 - regulation of response to tumor cell
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920414

DAPK1
Death-associated protein kinase 1

5

19

Small-scale

0.936

High

920536

KLH20
Kelch-like protein 20

3

2

Small-scale

0.901

High

920523

LIMA1
LIM domain and actin-binding protein 1

2

5

High-throughput

0.812

High

866621

CAZA2
F-actin-capping protein subunit alpha-2

2

5

High-throughput

0.811

High

866926

CAPZB
F-actin-capping protein subunit beta

2

4

High-throughput

0.811

High

717732

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

9

Small-scale

0.799

High

703511

MK01
Mitogen-activated protein kinase 1

1

14

Small-scale

0.774

High

920475

UNC5B
Netrin receptor UNC5B

2

7

Small-scale

0.757

High

920435

FADD
FAS-associated death domain protein

2

10

Small-scale

0.754

High

276447

PDCD6
Programmed cell death protein 6

1

16

Small-scale

0.740

High

691686

MK03
Mitogen-activated protein kinase 3

1

13

Small-scale

0.740

High

920544

NEMO
NF-kappa-B essential modulator

1

16

High-throughput

0.724

High

159172

ABLM1
Actin-binding LIM protein 1

1

2

High-throughput

0.692

High

284098

SRS10
Serine/arginine-rich splicing factor 10

1

4

High-throughput

0.692

High

335725

RPGF3
Rap guanine nucleotide exchange factor 3

1

8

High-throughput

0.692

High

362221

ABL1
Tyrosine-protein kinase ABL1

1

13

High-throughput

0.692

High

477961

SNRPA
U1 small nuclear ribonucleoprotein A

1

3

High-throughput

0.692

High

541006

PIM1
Serine/threonine-protein kinase pim-1

1

19

High-throughput

0.692

High

585775

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

17

High-throughput

0.692

High

640132

EPHA1
Ephrin type-A receptor 1

1

12

High-throughput

0.692

High

849058

ZAP70
Tyrosine-protein kinase ZAP-70

1

20

High-throughput

0.692

High

870118

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

3

High-throughput

0.692

High

920425

TBB4B
Tubulin beta-4B chain

1

18

High-throughput

0.692

High

920478

FXL14
F-box/LRR-repeat protein 14

1

4

High-throughput

0.692

High

920493

SCYL1
N-terminal kinase-like protein

1

13

High-throughput

0.692

High

920507

SGK2
Serine/threonine-protein kinase Sgk2

1

8

High-throughput

0.692

High

920509

PAK6
Serine/threonine-protein kinase PAK 6

1

12

High-throughput

0.692

High

920518

PIM2
Serine/threonine-protein kinase pim-2

1

18

High-throughput

0.692

High

920526

FBW1B
F-box/WD repeat-containing protein 11

1

12

High-throughput

0.692

High

920527

BORG2
Cdc42 effector protein 3

1

2

High-throughput

0.692

High

555645

ACTN1
Alpha-actinin-1

1

20

High-throughput

0.691

High

608513

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

High-throughput

0.691

High

692019

MARK3
MAP/microtubule affinity-regulating kinase 3

1

12

High-throughput

0.691

High

915048

CAZA1
F-actin-capping protein subunit alpha-1

1

5

High-throughput

0.691

High

920418

ARP3
Actin-related protein 3

1

9

High-throughput

0.691

High

920419

ARP2
Actin-related protein 2

1

9

High-throughput

0.691

High

920424

ACTC
Actin, alpha cardiac muscle 1

1

9

High-throughput

0.691

High

920430

ANK2
Ankyrin-2

1

15

High-throughput

0.691

High

920432

NEXN
Nexilin

1

13

High-throughput

0.691

High

920434

FLII
Protein flightless-1 homolog

1

11

High-throughput

0.691

High

920439

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

20

High-throughput

0.691

High

920441

SRC8
Src substrate cortactin

1

20

High-throughput

0.691

High

920467

MARK2
Serine/threonine-protein kinase MARK2

1

13

High-throughput

0.691

High

920517

MARK1
Serine/threonine-protein kinase MARK1

1

13

High-throughput

0.691

High

920438

CUL3
Cullin-3

1

13

Small-scale

0.665

High

920450

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

6

Small-scale

0.665

High

920456

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

Small-scale

0.665

High

920515

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.656

High

169073

ML12B
Myosin regulatory light chain 12B

1

20

Small-scale

0.647

High

920448

Q2YDB1
RAS guanyl-releasing protein 2

1

7

High-throughput

0.647

High

920469

GRP2
RAS guanyl-releasing protein 2

1

5

High-throughput

0.647

High

920428

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.629

High

920532

CHIP
E3 ubiquitin-protein ligase CHIP

2

14

High-throughput

0.629

High

227836

MYO1B
Unconventional myosin-Ib

2

20

High-throughput

0.628

High

318294

MYO1D
Unconventional myosin-Id

2

19

High-throughput

0.628

High

336380

SVIL
Supervillin

2

9

High-throughput

0.628

High

920433

TWF1
Twinfilin-1

2

6

High-throughput

0.628

High

920530

COR1C
Coronin-1C

2

7

High-throughput

0.628

High

920422

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

1

Small-scale

0.620

High

920458

LRCH2
Leucine-rich repeat and calponin homology domain-containing protein 2

1

13

High-throughput

0.618

High

328780

UNC5C
Netrin receptor UNC5C

1

6

Small-scale

0.618

High

374490

RASH
GTPase HRas

1

11

High-throughput

0.618

High

413461

P53
Cellular tumor antigen p53

1

7

Small-scale

0.618

High

461301

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

487124

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.618

High

507712

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.618

High

622556

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

3

Small-scale

0.618

High

718089

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

9

Small-scale

0.618

High

920420

RB11A
Ras-related protein Rab-11A

1

2

High-throughput

0.618

High

920465

UNC5A
Netrin receptor UNC5A

1

11

Small-scale

0.618

High

920472

MIB1
E3 ubiquitin-protein ligase MIB1

1

16

Small-scale

0.618

High

920541

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

10

High-throughput

0.618

High

920546

NS1BP
Influenza virus NS1A-binding protein

1

4

Small-scale

0.618

High

890800

TSC2
Tuberin

2

4

Small-scale

0.601

High

920423

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

2

5

Small-scale

0.595

High

612946

EGR1
Early growth response protein 1

1

0

High-throughput

0.586

High

573043

KPYM
Pyruvate kinase PKM

1

2

Small-scale

0.586

High

920443

BECN1
Beclin-1

1

0

Small-scale

0.584

High

346920

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.574

High

920498

ERP44
Endoplasmic reticulum resident protein 44

2

14

High-throughput

0.574

High

920514

TMOD3
Tropomodulin-3

2

4

High-throughput

0.574

High

920445

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.537

High

617283

ATF6A
Cyclic AMP-dependent transcription factor ATF-6 alpha

1

20

High-throughput

0.536

High

770360

T2FA
General transcription factor IIF subunit 1

1

4

High-throughput

0.536

High

829051

RFC5
Replication factor C subunit 5

1

2

High-throughput

0.536

High

920436

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

High-throughput

0.536

High

920437

PWP1
Periodic tryptophan protein 1 homolog

1

7

High-throughput

0.536

High

920442

CAPR1
Caprin-1

1

6

High-throughput

0.536

High

920444

STAR3
StAR-related lipid transfer protein 3

1

1

High-throughput

0.536

High

920447

TPD53
Tumor protein D53

1

1

High-throughput

0.536

High

920480

ARRD1
Arrestin domain-containing protein 1

1

3

High-throughput

0.536

High

920482

NECP1
Adaptin ear-binding coat-associated protein 1

1

1

High-throughput

0.536

High

920485

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.536

High

920495

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

2

High-throughput

0.536

High

920503

WWTR1
WW domain-containing transcription regulator protein 1

1

13

High-throughput

0.536

High

920508

SH22A
SH2 domain-containing protein 2A

1

18

High-throughput

0.536

High

920522

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

4

High-throughput

0.536

High

920524

ZMYM5
Zinc finger MYM-type protein 5

1

1

High-throughput

0.536

High

920534

BAIP2
BAR/IMD domain-containing adapter protein 2

1

13

High-throughput

0.536

High

920542

SNX9
Sorting nexin-9

1

3

High-throughput

0.536

High

123643

MYO1C
Unconventional myosin-Ic

1

19

High-throughput

0.536

High

174726

SPTN2
Spectrin beta chain, non-erythrocytic 2

1

20

High-throughput

0.536

High

179169

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

4

High-throughput

0.536

High

192698

ARPC5
Actin-related protein 2/3 complex subunit 5

1

1

High-throughput

0.536

High

224667

ACTN4
Alpha-actinin-4

1

20

High-throughput

0.536

High

256455

TOM1
Target of Myb1 membrane trafficking protein

1

3

High-throughput

0.536

High

270333

WDR1
WD repeat-containing protein 1

1

2

High-throughput

0.536

High

442273

GELS
Gelsolin

1

9

High-throughput

0.536

High

447719

TPM3
Tropomyosin alpha-3 chain

1

5

High-throughput

0.536

High

565835

EF2
Elongation factor 2

1

1

High-throughput

0.536

High

774039

ADDA
Alpha-adducin

1

9

High-throughput

0.536

High

774135

ADDB
Beta-adducin

1

8

High-throughput

0.536

High

920417

DEST
Destrin

1

6

High-throughput

0.536

High

920426

CNTP1
Contactin-associated protein 1

1

6

High-throughput

0.536

High

920429

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

20

High-throughput

0.536

High

920446

DREB
Drebrin

1

11

High-throughput

0.536

High

920449

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

2

High-throughput

0.536

High

920486

TSC1
Hamartin

1

18

Small-scale

0.536

High

920487

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

4

High-throughput

0.536

High

920488

COR2A
Coronin-2A

1

8

High-throughput

0.536

High

920497

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

1

High-throughput

0.536

High

920521

ADDG
Gamma-adducin

1

8

High-throughput

0.536

High

920529

MYO5B
Unconventional myosin-Vb

1

9

High-throughput

0.536

High

920531

MYO6
Unconventional myosin-VI

1

15

High-throughput

0.536

High

920533

COR2B
Coronin-2B

1

7

High-throughput

0.536

High

920535

COF2
Cofilin-2

1

6

High-throughput

0.536

High

920545

SCIN
Scinderin

1

9

High-throughput

0.536

High

920459

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

1

Small-scale

0.528

High

920490

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

920539

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.515

High

215990

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.513

High

328430

SCEL
Sciellin

1

0

High-throughput

0.513

High

333860

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.513

High

352753

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.513

High

873850

PCP4
Calmodulin regulator protein PCP4

1

0

High-throughput

0.513

High

920415

T2R60
Taste receptor type 2 member 60

1

0

High-throughput

0.513

High

920421

RS32
Small ribosomal subunit protein eS32

1

0

High-throughput

0.513

High

920427

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.513

High

920440

VGLL4
Transcription cofactor vestigial-like protein 4

1

0

High-throughput

0.513

High

920451

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.513

High

920457

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.513

High

920462

DUS1L
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

1

0

High-throughput

0.513

High

920468

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.513

High

920471

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

920474

HYCC2
Hyccin 2

1

0

High-throughput

0.513

High

920481

NECA1
N-terminal EF-hand calcium-binding protein 1

1

0

High-throughput

0.513

High

920496

DUX3
Putative double homeobox protein 3

1

0

High-throughput

0.513

High

920502

VN1R1
Vomeronasal type-1 receptor 1

1

0

High-throughput

0.513

High

920506

ZMAT4
Zinc finger matrin-type protein 4

1

0

High-throughput

0.513

High

920511

C42S1
CDC42 small effector protein 1

1

0

High-throughput

0.513

High

920513

MRGBP
MRG/MORF4L-binding protein

1

0

High-throughput

0.513

High

920520

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.513

High

920538

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.513

High

920543

SNURF
SNRPN upstream reading frame protein

1

0

High-throughput

0.513

High

179323

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

High-throughput

0.513

High

179483

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.513

High

920416

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.513

High

920525

SH3L2
SH3 domain-binding glutamic acid-rich-like protein 2

1

0

High-throughput

0.513

High

69434

A8K2B9
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.501

High

515624

TPC2A
Trafficking protein particle complex subunit 2

1

2

High-throughput

0.501

High

515684

TPC2B
Trafficking protein particle complex subunit 2B

1

2

High-throughput

0.501

High

920479

DTWD1
tRNA-uridine aminocarboxypropyltransferase 1

1

1

High-throughput

0.501

High

920484

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.501

High

569298

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

5

High-throughput

0.489

High

920431

SCRN3
Secernin-3

1

1

High-throughput

0.489

High

920453

LARGN
Protein Largen

1

1

High-throughput

0.489

High

920463

TTC27
Tetratricopeptide repeat protein 27

1

9

High-throughput

0.489

High

920473

DEN1C
DENN domain-containing protein 1C

1

6

High-throughput

0.489

High

920477

CNTRB
Centrobin

1

9

High-throughput

0.489

High

920504

CI037
Uncharacterized protein ARRDC1-AS1

1

1

High-throughput

0.489

High

920505

RPAP3
RNA polymerase II-associated protein 3

1

19

High-throughput

0.489

High

920512

TB22B
TBC1 domain family member 22B

1

2

High-throughput

0.489

High

701960

TMOD1
Tropomodulin-1

1

4

High-throughput

0.489

High

920494

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.489

High

920500

CP250
Centrosome-associated protein CEP250

1

7

High-throughput

0.489

High

920516

TMOD2
Tropomodulin-2

1

4

High-throughput

0.489

High

920528

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.489

High

920537

SGT1
Protein SGT1 homolog

1

14

High-throughput

0.489

High

403934

GCR
Glucocorticoid receptor

1

7

Small-scale

0.481

High

139117

KRIT1
Krev interaction trapped protein 1

1

17

Small-scale

0.479

High

358649

LDHA
L-lactate dehydrogenase A chain

1

7

High-throughput

0.479

High

561964

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.479

High

690851

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

895898

F10A1
Hsc70-interacting protein

1

20

Small-scale

0.479

High

920454

DCAF6
DDB1- and CUL4-associated factor 6

1

11

High-throughput

0.479

High

920540

TTLL3
Tubulin monoglycylase TTLL3

1

2

High-throughput

0.479

High

353137

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

920510

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

332494

CCDB1
Cyclin-D1-binding protein 1

1

0

Small-scale

0.458

High

920492

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

669853

MCM3
DNA replication licensing factor MCM3

1

8

Small-scale

0.445

High

920489

CSN5
COP9 signalosome complex subunit 5

1

3

Small-scale

0.445

High

920455

PRC2B
Protein PRRC2B

1

14

High-throughput

0.439

High

561115

GILT
Gamma-interferon-inducible lysosomal thiol reductase

5

0

High-throughput

0.376

High

920452

ORML2
ORM1-like protein 2

1

0

High-throughput

0.279

Low

920461

JHY
Jhy protein homolog

1

0

High-throughput

0.279

Low

920464

GAK1B
Golgi-associated kinase 1B

1

0

High-throughput

0.279

Low

920466

CC149
Coiled-coil domain-containing protein 149

1

0

High-throughput

0.279

Low

920470

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.279

Low

920476

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

1

0

High-throughput

0.279

Low

920483

MFI
Protein MFI

1

0

High-throughput

0.279

Low

920491

PP14A
Protein phosphatase 1 regulatory subunit 14A

1

0

High-throughput

0.279

Low

920499

LMF2
Lipase maturation factor 2

1

0

High-throughput

0.279

Low

920501

SPR2G
Small proline-rich protein 2G

1

0

High-throughput

0.279

Low

920519

SLAI2
SLAIN motif-containing protein 2

1

0

High-throughput

0.279

Low

506002

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.261

Low

920460

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025