HitPredict

Interactor 1: MYC (P01106)
Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
Gene: MYC

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	29467282, 36199071, 20852628
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0046983 - protein dimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Hs			1 605
+	Hs
		252937 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		347517 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		348444 MYC_MOUSE (1-454): 4.33e-119: 357: 89.01		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Hs
		346159 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		252935 MITF_HUMAN (155-450): 1.47e-29: 123: 14.47		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		840227 MXI1_HUMAN (321-450): 2.55e-29: 116: 27.69		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		348035 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		NLE1_HUMAN (33-408): 1.35e-41: 159: 13.21
+	Hs
		209372 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		346404 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		196936 MYC_HUMAN (1-454): 1.73e-122: 366: 100.00		PRP4_HUMAN (387-594): 6.19e-35: 140: 23.66
+	Hs
		379688 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Mm
		1112323 SRBP2_MOUSE (124-446): 2.23e-37: 147: 13.60		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Mm
		1257396 SRBP1_MOUSE (172-453): 4.45e-35: 140: 16.61		FBXW7_MOUSE (76-527): 2.98e-83: 277: 23.71
+	Hs
		738987 SRBP1_HUMAN (95-453): 2.54e-33: 135: 16.19		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		209375 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		379200 MYCN_HUMAN (12-451): 9.39e-59: 201: 33.40		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Dm
		1375911 MYC_DROME (210-454): 3.25e-30: 126: 26.74		FBXW7_DROME (414-604): 1.53e-53: 199: 30.73
+	Hs
		607803 USF1_HUMAN (175-453): 1.02e-39: 146: 18.40		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		903353 MGAP_HUMAN (151-449): 1.22e-27: 118: 17.71		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	At
		189017 MYC2_ARATH (200-454): 1.78e-32: 132: 18.05		GBLPA_ARATH (439-584): 1.06e-09: 62.4: 31.21