HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MRP1 (P33527)
Multidrug resistance-associated protein 1 (EC 7.6.2.2) (ATP-binding cassette sub-family C member 1) (Glutathione-S-conjugate-translocating ATPase ABCC1) (EC 7.6.2.3) (Leukotriene C(4) transporter) (LTC4 transporter)
Gene: ABCC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30442766, 30639242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1531
+	Hs
		349920 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MRP1_HUMAN (1-1531): 0: 1288: 100.00
+	Hs
		706711 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MRP1_HUMAN (1-1531): 0: 1288: 100.00
+	Hs
		349151 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MRP1_HUMAN (1-1531): 0: 1288: 100.00
+	Hs
		706699 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		MRP1_HUMAN (1-1531): 0: 1288: 100.00
+	Hs
		706694 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		MRP1_HUMAN (1-1531): 0: 1288: 100.00
+	Hs
		179330 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MRP3_HUMAN (3-1530): 0: 1168: 55.12
+	Hs
		350425 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MRP2_HUMAN (3-1530): 0: 1086: 45.53
+	Sc
		350810 RAS2_YEAST (3-179): 5.76e-58: 186: 61.54		YCFI_YEAST (27-1531): 0: 980: 38.73
+	Hs
		179388 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MRP5_HUMAN (201-1524): 0: 840: 32.39
+	Hs
		179413 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MRP5_HUMAN (201-1524): 0: 840: 32.39
+	Hs
		179387 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		MRP5_HUMAN (201-1524): 0: 840: 32.39
+	Hs
		179402 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		MRP5_HUMAN (201-1524): 0: 840: 32.39
+	Hs
		349809 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MDR1_HUMAN (263-871): 2.57e-114: 394: 17.09
+	Hs
		437187 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		MDR1_HUMAN (263-871): 2.57e-114: 394: 17.09
+	Sc
		350816 RAS2_YEAST (3-179): 5.76e-58: 186: 61.54		YOR1_YEAST (245-880): 6.81e-64: 242: 16.59