Protein: ERLN2
Erlin-2 (Endoplasmic reticulum lipid raft-associated protein 2) (Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2) (SPFH domain-containing protein 2)

Gene: ERLN2, ERLIN2
Organism: Homo sapiens
Interactions: 235
UniProt ID: O94905

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0008203 - cholesterol metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

266081

ERLN1
Erlin-1

9

5

Small-scale

0.975

High

299969

RN185
E3 ubiquitin-protein ligase RNF185

5

12

Small-scale

0.709

High

299826

BIP
Endoplasmic reticulum chaperone BiP

4

4

Small-scale

0.699

High

300005

AMFR
E3 ubiquitin-protein ligase AMFR

4

7

Small-scale

0.697

High

299971

RN170
E3 ubiquitin-protein ligase RNF170

4

3

Small-scale

0.694

High

299847

STOM
Stomatin

1

18

High-throughput

0.691

High

299850

CALX
Calnexin

4

2

Small-scale

0.691

High

181023

INSI1
Insulin-induced gene 1 protein

4

1

Small-scale

0.686

High

299900

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

4

4

Small-scale

0.676

High

299977

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

3

3

Small-scale

0.671

High

299937

SYVN1
E3 ubiquitin-protein ligase synoviolin

3

14

Small-scale

0.662

High

299830

CFTR
Cystic fibrosis transmembrane conductance regulator

3

3

High-throughput

0.650

High

226115

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

299825

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

6

Small-scale

0.640

High

299864

GSTM5
Glutathione S-transferase Mu 5

3

0

High-throughput

0.638

High

299934

RIC3
Protein RIC-3

3

0

High-throughput

0.638

High

299867

DUS3
Dual specificity protein phosphatase 3

2

3

High-throughput

0.628

High

299928

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

2

3

High-throughput

0.628

High

299963

CCD47
PAT complex subunit CCDC47

2

1

Small-scale

0.628

High

300003

VAPA
Vesicle-associated membrane protein-associated protein A

2

7

High-throughput

0.628

High

299854

PHB1
Prohibitin 1

1

16

High-throughput

0.618

High

201735

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

2

1

Small-scale

0.611

High

299810

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

2

4

Small-scale

0.611

High

299865

PSN1
Presenilin-1

2

1

Small-scale

0.611

High

299871

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

2

1

High-throughput

0.611

High

299874

SC61B
Protein transport protein Sec61 subunit beta

2

1

Small-scale

0.611

High

299908

MBRL
Membralin

2

1

Small-scale

0.611

High

299958

NICA
Nicastrin

2

1

Small-scale

0.611

High

299967

FAF2
FAS-associated factor 2

2

4

Small-scale

0.611

High

299924

CD109
CD109 antigen

2

0

High-throughput

0.585

High

299884

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

2

6

Small-scale

0.584

High

299993

FBX6
F-box only protein 6

2

3

High-throughput

0.584

High

299876

RHOA
Transforming protein RhoA

2

14

High-throughput

0.571

High

62189

ARRD5
Arrestin domain-containing protein 5

1

6

High-throughput

0.536

High

299801

VAMP5
Vesicle-associated membrane protein 5

1

1

High-throughput

0.536

High

299808

FINC
Fibronectin

1

2

High-throughput

0.536

High

299832

ENPL
Endoplasmin

1

1

Small-scale

0.536

High

299839

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

5

Small-scale

0.536

High

299840

TCPA
T-complex protein 1 subunit alpha

1

2

Small-scale

0.536

High

299842

VDAC1
Voltage-dependent anion-selective channel protein 1

1

7

High-throughput

0.536

High

299845

ADA1D
Alpha-1D adrenergic receptor

1

3

Small-scale

0.536

High

299857

SOAT1
Sterol O-acyltransferase 1

1

3

High-throughput

0.536

High

299863

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.536

High

299866

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.536

High

299868

NEK4
Serine/threonine-protein kinase Nek4

1

2

High-throughput

0.536

High

299872

XPO2
Exportin-2

1

6

Small-scale

0.536

High

299890

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.536

High

299897

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

299903

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.536

High

299915

CSCL2
CSC1-like protein 2

1

1

High-throughput

0.536

High

299950

UBAC2
Ubiquitin-associated domain-containing protein 2

1

1

High-throughput

0.536

High

299968

HDA11
Histone deacetylase 11

1

2

High-throughput

0.536

High

299980

OSBL8
Oxysterol-binding protein-related protein 8

1

1

High-throughput

0.536

High

299983

UN93B
Protein unc-93 homolog B1

1

2

High-throughput

0.536

High

299990

RTN4
Reticulon-4

1

3

High-throughput

0.536

High

300010

GOT1B
Vesicle transport protein GOT1B

1

4

High-throughput

0.536

High

300012

SRPRB
Signal recognition particle receptor subunit beta

1

7

Small-scale

0.536

High

177763

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.515

High

299809

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.515

High

299829

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.515

High

299848

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

299880

IFM3
Interferon-induced transmembrane protein 3

1

2

High-throughput

0.515

High

299956

RN139
E3 ubiquitin-protein ligase RNF139

1

9

Small-scale

0.515

High

299957

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.515

High

299994

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.515

High

300006

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.515

High

118144

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.513

High

123443

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.513

High

299812

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.513

High

299844

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.513

High

299896

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.513

High

299907

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

Small-scale

0.513

High

299931

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

299987

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.513

High

299879

TCPB
T-complex protein 1 subunit beta

1

2

Small-scale

0.501

High

299813

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.500

High

299843

FGFR4
Fibroblast growth factor receptor 4

1

12

High-throughput

0.500

High

299883

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

8

High-throughput

0.500

High

299919

STYK1
Tyrosine-protein kinase STYK1

1

6

High-throughput

0.500

High

299824

FURIN
Furin

1

0

High-throughput

0.493

High

299851

GALNS
N-acetylgalactosamine-6-sulfatase

1

1

High-throughput

0.489

High

299869

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

2

High-throughput

0.489

High

299930

COX15
Heme A synthase COX15

1

2

High-throughput

0.489

High

299942

MIRO1
Mitochondrial Rho GTPase 1

1

18

Small-scale

0.489

High

299999

TBA8
Tubulin alpha-8 chain

1

3

High-throughput

0.489

High

48209

ESYT2
Extended synaptotagmin-2

1

4

High-throughput

0.479

High

155225

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

167786

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.479

High

169340

BET1
BET1 homolog

1

1

High-throughput

0.479

High

204855

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

298011

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

299800

UBR5
E3 ubiquitin-protein ligase UBR5

1

1

High-throughput

0.479

High

299802

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

299807

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.479

High

299814

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

299815

HSPB1
Heat shock protein beta-1

1

1

Small-scale

0.479

High

299819

TBB5
Tubulin beta chain

1

2

High-throughput

0.479

High

299820

ADRB2
Beta-2 adrenergic receptor

1

3

High-throughput

0.479

High

299821

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

299827

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

299828

UBL4A
Ubiquitin-like protein 4A

1

6

High-throughput

0.479

High

299831

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.479

High

299833

CCNB1
G2/mitotic-specific cyclin-B1

1

2

Small-scale

0.479

High

299835

AMPN
Aminopeptidase N

1

2

High-throughput

0.479

High

299836

PPAP
Prostatic acid phosphatase

1

1

High-throughput

0.479

High

299838

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

299841

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

High-throughput

0.479

High

299852

HSP74
Heat shock 70 kDa protein 4

1

3

Small-scale

0.479

High

299858

BASI
Basigin

1

1

High-throughput

0.479

High

299859

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

299860

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

299873

TPTE
Putative tyrosine-protein phosphatase TPTE

1

1

High-throughput

0.479

High

299877

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

299878

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.479

High

299881

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

299882

TAP2
Antigen peptide transporter 2

1

2

Small-scale

0.479

High

299885

SRBP2
Sterol regulatory element-binding protein 2

1

2

Small-scale

0.479

High

299886

SEPR
Prolyl endopeptidase FAP

1

2

Small-scale

0.479

High

299888

STK3
Serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

299892

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

299893

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.479

High

299898

DCTN1
Dynactin subunit 1

1

2

High-throughput

0.479

High

299899

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.479

High

299902

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

299905

DUS7
Dual specificity protein phosphatase 7

1

3

High-throughput

0.479

High

299909

TM41B
Transmembrane protein 41B

1

1

High-throughput

0.479

High

299913

EPHAA
Ephrin type-A receptor 10

1

6

High-throughput

0.479

High

299917

FTM
Protein fantom

1

5

High-throughput

0.479

High

299923

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

299929

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.479

High

299935

CNTRL
Centriolin

1

2

High-throughput

0.479

High

299936

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

299939

TAXB1
Tax1-binding protein 1

1

5

High-throughput

0.479

High

299945

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

299948

EMC1
ER membrane protein complex subunit 1

1

3

High-throughput

0.479

High

299951

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.479

High

299954

RBCC1
RB1-inducible coiled-coil protein 1

1

4

High-throughput

0.479

High

299959

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

3

High-throughput

0.479

High

299965

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

299966

APH1A
Gamma-secretase subunit APH-1A

1

1

Small-scale

0.479

High

299970

DDRGK
DDRGK domain-containing protein 1

1

2

High-throughput

0.479

High

299972

SCLT1
Sodium channel and clathrin linker 1

1

3

High-throughput

0.479

High

299975

RNF5
E3 ubiquitin-protein ligase RNF5

1

10

Small-scale

0.479

High

299978

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.479

High

299979

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

299981

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

3

Small-scale

0.479

High

299985

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

299986

ECT2
Protein ECT2

1

4

High-throughput

0.479

High

299992

ANLN
Anillin

1

2

High-throughput

0.479

High

299995

T106B
Transmembrane protein 106B

1

3

High-throughput

0.479

High

300001

PEN2
Gamma-secretase subunit PEN-2

1

1

Small-scale

0.479

High

300002

WWOX
WW domain-containing oxidoreductase

1

6

High-throughput

0.479

High

300007

FAF1
FAS-associated factor 1

1

4

High-throughput

0.479

High

300009

FND3A
Fibronectin type-III domain-containing protein 3A

1

3

High-throughput

0.479

High

300011

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

299822

CATB
Cathepsin B

1

2

High-throughput

0.470

High

299846

CATS
Cathepsin S

1

1

High-throughput

0.470

High

299912

PRC2B
Protein PRRC2B

1

1

High-throughput

0.470

High

300004

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.470

High

117324

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

299803

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

299805

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

299811

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

Small-scale

0.458

High

299817

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

299818

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

299834

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.458

High

299837

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

299855

MERL
Merlin

1

0

High-throughput

0.458

High

299889

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.458

High

299891

CLN3
Battenin

1

0

Small-scale

0.458

High

299901

CASP8
Caspase-8

1

0

Small-scale

0.458

High

299906

TECT1
Tectonic-1

1

0

High-throughput

0.458

High

299910

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

0

High-throughput

0.458

High

299911

MKS3
Meckelin

1

0

High-throughput

0.458

High

299916

WLS
Protein wntless homolog

1

0

Small-scale

0.458

High

299921

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

299938

PAQR2
Adiponectin receptor protein 2

1

0

Small-scale

0.458

High

299953

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

299955

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

299961

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.458

High

299962

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

299974

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

299976

DERL1
Derlin-1

1

0

Small-scale

0.458

High

299982

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

299991

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

299804

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

Small-scale

0.445

High

299816

JUN
Transcription factor Jun

1

4

High-throughput

0.445

High

299853

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

299862

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

1

High-throughput

0.445

High

299875

RAB8A
Ras-related protein Rab-8A

1

3

Small-scale

0.445

High

299887

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

1

High-throughput

0.445

High

299894

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

299914

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

299918

PKHA7
Pleckstrin homology domain-containing family A member 7

1

9

High-throughput

0.445

High

299947

CD177
CD177 antigen

1

2

Small-scale

0.445

High

299952

MOT11
Monocarboxylate transporter 11

1

1

High-throughput

0.445

High

299973

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

4

High-throughput

0.445

High

299988

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

299998

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

1

Small-scale

0.445

High

300008

ITM2B
Integral membrane protein 2B

1

6

High-throughput

0.445

High

59071

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.437

High

172951

RT12
Small ribosomal subunit protein uS12m

1

2

High-throughput

0.437

High

299849

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

299856

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

299861

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.437

High

299870

TXTP
Tricarboxylate transport protein, mitochondrial

1

5

High-throughput

0.437

High

299922

ARSK
Arylsulfatase K

1

1

High-throughput

0.437

High

299925

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

299926

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

299927

CE128
Centrosomal protein of 128 kDa

1

3

High-throughput

0.437

High

299932

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.437

High

299933

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

299941

GOLI
E3 ubiquitin-protein ligase RNF130

1

10

High-throughput

0.437

High

299944

S15A3
Solute carrier family 15 member 3

1

5

High-throughput

0.437

High

299949

ARL10
ADP-ribosylation factor-like protein 10

1

9

High-throughput

0.437

High

299960

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

299964

S2546
Mitochondrial outer membrane protein SLC25A46

1

1

High-throughput

0.437

High

300000

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

299984

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.426

High

300013

ICOS
Inducible T-cell costimulator

1

0

Small-scale

0.426

High

99532

F5H1C8
Solute carrier family 15 member 3

1

5

High-throughput

0.407

High

299920

Q6LC01
Tubulin beta chain

1

2

High-throughput

0.407

High

299997

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

3

0

High-throughput

0.347

High

299940

AMGO1
Amphoterin-induced protein 1

2

0

High-throughput

0.318

High

206884

CHSTA
Carbohydrate sulfotransferase 10

1

0

High-throughput

0.279

Low

299823

SP1
Transcription factor Sp1

1

0

High-throughput

0.261

Low

233120

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

299806

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

299895

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

299943

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

299946

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.249

Low

299989

SHCAF
SIN3-HDAC complex-associated factor

1

0

Small-scale

0.249

Low

299996

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

867

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

299904

MLF2
Myeloid leukemia factor 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024