HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MP2K2 (P36507)
Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
Gene: MAP2K2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	34591642
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005794 - Golgi apparatus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 400
+	Hs
		350092 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14
+	Hs
		349916 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		AKT2_HUMAN (31-365): 1.76e-125: 372: 20.95
+	Hs
		682177 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		AKT2_HUMAN (31-365): 1.76e-125: 372: 20.95
+	Rn
		442950 RASK_RAT (1-189): 3.25e-85: 251: 87.90		Q6P751_RAT (69-375): 3.7e-124: 362: 25.16
+	Hs
		349260 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MP2K1_HUMAN (2-399): 2.32e-128: 376: 78.14
+	Hs
		348536 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		AKT1_HUMAN (43-351): 3.37e-124: 369: 20.12
+	Hs
		349133 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Hs
		682159 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		AKT2_HUMAN (31-365): 1.76e-125: 372: 20.95
+	Hs
		895051 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		KPCT_HUMAN (15-364): 1.46e-121: 369: 22.34
+	Hs
		625461 RB11B_HUMAN (4-184): 2.97e-73: 221: 32.79		CDK2_HUMAN (69-375): 3.95e-124: 362: 25.16
+	Hs
		894729 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		STK4_HUMAN (41-377): 2.43e-109: 331: 28.74
+	Hs
		349801 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		CDK1_HUMAN (69-375): 8.1e-111: 328: 24.76
+	Hs
		894835 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		STK24_HUMAN (52-388): 2.56e-104: 317: 29.83
+	Mm
		814032 RAB35_MOUSE (4-171): 6.96e-84: 247: 34.71		MP2K4_MOUSE (2-396): 1.64e-101: 308: 32.52
+	Hs
		350188 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KS6A1_HUMAN (1-347): 1.75e-92: 295: 19.33
+	Hs
		914500 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		STK24_HUMAN (52-388): 2.56e-104: 317: 29.83
+	Hs
		348674 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		KS6A1_HUMAN (1-347): 1.75e-92: 295: 19.33
+	Hs
		349336 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		KS6A1_HUMAN (1-347): 1.75e-92: 295: 19.33
+	Hs
		349208 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MP2K6_HUMAN (66-383): 7.24e-64: 209: 36.89
+	Hs
		153063 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		MP2K7_HUMAN (39-383): 1.39e-58: 198: 34.82