HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 646
+	Hs
		349952 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		793318 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		349176 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00
+	Hs
		350572 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ROBO2_HUMAN (1-646): 1.16e-96: 325: 14.69
+	Hs
		350155 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		1045043 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		CD166_HUMAN (13-607): 2.71e-98: 314: 22.33
+	Hs
		349841 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63
+	Hs
		530172 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63
+	Hs
		348489 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63
+	Hs
		349096 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63
+	Hs
		350138 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68
+	Hs
		348643 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		PTK7_HUMAN (17-627): 1.64e-70: 249: 12.68
+	Hs
		350455 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77
+	Hs
		1070344 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77
+	Hs
		348867 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77
+	Hs
		350746 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29
+	Hs
		1070491 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29
+	Hs
		349043 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		ROBO1_HUMAN (17-271): 4.39e-21: 100: 14.29
+	Hs
		350405 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TITIN_HUMAN (50-634): 4.44e-11: 68.6: 11.22
+	Hs
		350182 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		RAGE_HUMAN (99-281): 1.17e-09: 62.8: 29.84