HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: GDS1 (P52306)
Rap1 GTPase-GDP dissociation stimulator 1 (Exchange factor smgGDS) (SMG GDS protein) (SMG P21 stimulatory GDP/GTP exchange protein)
Gene: RAP1GDS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.885

Property	Details
Experiments	11948427, 30194290, 32296183, unassigned1304
Identification Methods	two hybrid, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Arm~Ras
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 607
+	Hs
		349994 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		349206 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854133 RAB1B_HUMAN (4-187): 1.35e-75: 226: 33.51		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854082 RAP1B_HUMAN (1-165): 1.02e-61: 191: 56.89		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		854088 RAP1A_HUMAN (1-165): 1.22e-60: 188: 56.29		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Hs
		506444 RALB_HUMAN (4-170): 7.31e-56: 177: 52.07		GDS1_HUMAN (1-607): 0: 917: 100.00
+	Dm
		51789 RALA_DROME (4-169): 1.5e-59: 186: 52.70		GDS1_DROME (62-536): 0: 540: 31.27
+	Dm
		51795 Q962I2_DROME (4-170): 1.83e-59: 186: 51.79		GDS1_DROME (62-536): 0: 540: 31.27