HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MARK2 (Q7KZI7)
Serine/threonine-protein kinase MARK2 (EC 2.7.11.1) (EC 2.7.11.26) (ELKL motif kinase 1) (EMK-1) (MAP/microtubule affinity-regulating kinase 2) (PAR1 homolog) (PAR1 homolog b) (Par-1b) (Par1b)
Gene: MARK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.827

Property	Details
Experiments	30442766, 30639242, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 788
+	Hs
		350286 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		1070265 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		349425 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		914159 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		895142 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		MARK2_HUMAN (1-788): 0: 790: 100.00
+	Hs
		349893 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647896 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		350628 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Hs
		348523 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		1070428 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MARK1_HUMAN (3-788): 0: 644: 63.22
+	Hs
		349139 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647864 RB11A_HUMAN (4-184): 1.5e-74: 224: 33.88		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Hs
		647857 RAB2A_HUMAN (4-185): 1.53e-73: 222: 31.52		MARK3_HUMAN (3-788): 0: 656: 60.40
+	Rn
		404417 RAB2A_RAT (4-185): 4.13e-77: 231: 30.98		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Rn
		192821 RB11B_RAT (4-184): 2.97e-73: 221: 32.79		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00
+	Rn
		871206 RAB14_RAT (4-185): 2.1e-73: 221: 29.35		AAPK1_RAT (31-560): 2.85e-141: 429: 30.00