HitPredict

Interactor 1: RASN (P01111)
GTPase NRas (EC 3.6.5.2) (Transforming protein N-Ras)
Gene: NRAS

Interactor 2: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30442766, 30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0000165 - MAPK cascade GO:0005794 - Golgi apparatus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 1332
+	Hs
		350342 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		1070297 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MINK1_HUMAN (1-1332): 0: 1277: 100.00
+	Hs
		350664 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		348995 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		TNIK_HUMAN (1-1332): 0: 1098: 60.83
+	Hs
		324711 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324808 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324709 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		324710 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		M4K4_HUMAN (1-1332): 0: 1026: 57.14
+	Hs
		350286 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		1070265 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		348748 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		349425 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		MARK2_HUMAN (8-747): 3.42e-132: 427: 14.86
+	Hs
		894729 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		STK4_HUMAN (5-469): 5.1e-119: 381: 32.99
+	Hs
		894835 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		STK24_HUMAN (20-443): 5.39e-117: 374: 34.98
+	Hs
		350320 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		894759 RAB8A_HUMAN (4-185): 2.24e-84: 249: 36.02		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		348766 RASN_HUMAN (1-189): 9.9e-80: 236: 100.00		M4K3_HUMAN (19-441): 4.42e-110: 370: 37.24
+	Hs
		349428 RASH_HUMAN (1-188): 8.6e-78: 232: 85.64		NRK_HUMAN (1-865): 2.05e-105: 369: 28.26
+	Hs
		350725 RASK_HUMAN (16-189): 7.56e-85: 249: 85.71		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60
+	Hs
		1070479 RAB35_HUMAN (4-171): 6.96e-84: 247: 34.71		M4K5_HUMAN (5-307): 6.97e-71: 257: 45.60