HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PLCD1 (P51178)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-1) (Phospholipase C-III) (PLC-III) (Phospholipase C-delta-1) (PLC-delta-1)
Gene: PLCD1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30442766
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_12~Ras
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 756
+	Hs
		348580 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		349987 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		846022 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		506371 RALA_HUMAN (4-168): 3.3e-59: 185: 54.22		PLCD1_HUMAN (1-756): 0: 888: 100.00
+	Hs
		350690 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCL2_HUMAN (18-756): 0: 801: 36.95
+	Hs
		349735 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCL2_HUMAN (18-756): 0: 801: 36.95
+	Hs
		348942 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		350581 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		350087 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB3_HUMAN (9-756): 0: 705: 28.07
+	Hs
		914080 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCB4_HUMAN (16-755): 0: 722: 29.80
+	Hs
		349665 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB1_HUMAN (9-756): 0: 708: 29.07
+	Hs
		349256 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB3_HUMAN (9-756): 0: 705: 28.07
+	Hs
		348700 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		350215 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCH1_HUMAN (438-756): 1.24e-73: 263: 37.77
+	Hs
		253284 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCH2_HUMAN (463-756): 9.6e-77: 272: 39.26
+	Hs
		348976 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCE1_HUMAN (453-751): 2.37e-63: 233: 27.07
+	Hs
		580971 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCG1_HUMAN (478-754): 4.91e-75: 266: 36.56
+	Hs
		349695 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCE1_HUMAN (453-751): 2.37e-63: 233: 27.07
+	Hs
		919682 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		PLCE1_HUMAN (453-751): 2.37e-63: 233: 27.07