HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: SHPS1 (P78324)
Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
Gene: SIRPA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30194290
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 504
+	Hs
		348609 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00
+	Hs
		350059 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		SHPS1_HUMAN (1-504): 4.62e-114: 348: 100.00
+	Hs
		348808 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		CADM4_HUMAN (38-426): 3.78e-56: 194: 16.92
+	Hs
		350155 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		349305 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		CD166_HUMAN (1-312): 3.34e-54: 193: 18.62
+	Hs
		211414 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		SIGL6_HUMAN (25-503): 2.38e-51: 182: 13.94
+	Hs
		349043 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		350746 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		350572 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		ROBO2_HUMAN (24-494): 2.34e-25: 112: 11.56
+	Hs
		348867 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		350513 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		CADM1_HUMAN (41-289): 2.77e-25: 109: 21.18
+	Hs
		350455 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		914506 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		349775 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		ROBO1_HUMAN (24-497): 2.8e-28: 121: 12.25
+	Hs
		349617 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		CADM1_HUMAN (41-289): 2.77e-25: 109: 21.18
+	Hs
		914281 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		349572 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		KIRR1_HUMAN (150-493): 1.89e-21: 100: 12.68
+	Hs
		350405 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20
+	Hs
		914253 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		TITIN_HUMAN (43-445): 2.05e-11: 69: 11.20