Protein: APC1
Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Mitotic checkpoint regulator) (Testis-specific gene 24 protein)

Gene: APC1, ANAPC1
Organism: Homo sapiens
Interactions: 147
UniProt ID: Q9H1A4

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol
GO:0007091 - metaphase/anaphase transition of mitotic cell cycle
GO:0007346 - regulation of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1430910

APC5
Anaphase-promoting complex subunit 5

5

1

Small-scale

0.903

High

1430908

CDC23
Cell division cycle protein 23 homolog

4

11

Small-scale

0.887

High

718623

CDC27
Cell division cycle protein 27 homolog

14

9

Small-scale

0.757

High

1430911

APC4
Anaphase-promoting complex subunit 4

10

1

Small-scale

0.749

High

1086905

CDC20
Cell division cycle protein 20 homolog

10

10

Small-scale

0.747

High

1093044

CDC16
Cell division cycle protein 16 homolog

6

11

Small-scale

0.737

High

1430912

ANC2
Anaphase-promoting complex subunit 2

6

4

Small-scale

0.722

High

1430915

FZR1
Fizzy-related protein homolog

5

10

Small-scale

0.714

High

251808

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

4

2

Small-scale

0.691

High

1430920

LMBL1
Lethal(3)malignant brain tumor-like protein 1

5

0

High-throughput

0.690

High

1099776

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

3

1

Small-scale

0.667

High

1430902

LATS2
Serine/threonine-protein kinase LATS2

3

1

Small-scale

0.662

High

1387373

APC16
Anaphase-promoting complex subunit 16

4

0

High-throughput

0.661

High

1340913

CDC26
Anaphase-promoting complex subunit CDC26

4

0

High-throughput

0.658

High

920267

PLK1
Serine/threonine-protein kinase PLK1

3

2

High-throughput

0.656

High

1129739

MDC1
Mediator of DNA damage checkpoint protein 1

3

1

Small-scale

0.646

High

948587

APC15
Anaphase-promoting complex subunit 15

3

0

Small-scale

0.638

High

1101896

SKP2
S-phase kinase-associated protein 2

3

0

Small-scale

0.638

High

1412125

APC13
Anaphase-promoting complex subunit 13

3

0

High-throughput

0.634

High

908856

NEK2
Serine/threonine-protein kinase Nek2

3

1

Small-scale

0.633

High

1430909

APC7
Anaphase-promoting complex subunit 7

3

11

Small-scale

0.624

High

1430914

FBX5
F-box only protein 5

2

0

Small-scale

0.612

High

1195383

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

1116004

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

0

High-throughput

0.585

High

1329864

SIR6
NAD-dependent protein deacylase sirtuin-6

2

1

Small-scale

0.584

High

396919

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

346311

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

0

High-throughput

0.559

High

980307

H4
Histone H4

2

0

High-throughput

0.559

High

1114266

CUL3
Cullin-3

2

0

High-throughput

0.559

High

1430907

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

1430917

TRI33
E3 ubiquitin-protein ligase TRIM33

2

0

Small-scale

0.559

High

1036549

ID2
DNA-binding protein inhibitor ID-2

1

0

Small-scale

0.537

High

857556

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.536

High

1163199

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

261555

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

296827

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

455867

H10
Histone H1.0

1

0

High-throughput

0.513

High

783659

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.513

High

788774

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

867413

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

872736

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

884229

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

902892

BLK
Tyrosine-protein kinase Blk

1

0

High-throughput

0.513

High

992327

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1111259

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1383850

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1404386

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1417873

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

1420216

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1430900

PAK6
Serine/threonine-protein kinase PAK 6

1

0

High-throughput

0.513

High

1430919

CRYL1
Lambda-crystallin homolog

1

0

High-throughput

0.513

High

353824

PTTG1
Securin

1

0

Small-scale

0.480

High

374918

RASH
GTPase HRas

1

0

Small-scale

0.480

High

508604

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

964452

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

1162698

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

260438

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

292867

GRAP2
GRB2-related adapter protein 2

1

2

High-throughput

0.479

High

349238

LATS1
Serine/threonine-protein kinase LATS1

1

1

Small-scale

0.479

High

754985

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

831407

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

862444

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

994371

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.479

High

1089014

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1257128

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1280488

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1287014

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1367240

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1384433

PF21A
PHD finger protein 21A

1

1

High-throughput

0.479

High

1428963

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1430896

RPAP3
RNA polymerase II-associated protein 3

1

1

High-throughput

0.479

High

1430901

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.479

High

1430903

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.479

High

1430921

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

Small-scale

0.479

High

1381239

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

223323

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

246937

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

316002

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

317219

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

Small-scale

0.458

High

567482

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

573887

CCNB1
G2/mitotic-specific cyclin-B1

1

0

Small-scale

0.458

High

696470

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

958714

CSN2
COP9 signalosome complex subunit 2

1

0

Small-scale

0.458

High

965233

WDR5
WD repeat-containing protein 5

1

0

Small-scale

0.458

High

998793

H31
Histone H3.1

1

0

High-throughput

0.458

High

1005087

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1030035

RELB
Transcription factor RelB

1

0

Small-scale

0.458

High

1106067

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

0

High-throughput

0.458

High

1108141

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1178369

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1310791

CUL9
Cullin-9

1

0

Small-scale

0.458

High

1336840

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1397106

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1397418

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1430894

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

0

High-throughput

0.458

High

1430898

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1430904

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1430913

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1430918

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

1430922

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

224362

BUB3
Mitotic checkpoint protein BUB3

1

1

High-throughput

0.445

High

1384262

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.445

High

1430916

APC10
Anaphase-promoting complex subunit 10

1

3

High-throughput

0.445

High

1141301

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

1430899

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.437

High

1430906

HECW2
E3 ubiquitin-protein ligase HECW2

1

1

High-throughput

0.437

High

49012

MED19
Mediator of RNA polymerase II transcription subunit 19

1

0

High-throughput

0.426

High

1199690

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1209641

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1273863

MICA3
[F-actin]-monooxygenase MICAL3

1

0

Small-scale

0.426

High

1428345

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.426

High

370427

KNG1
Kininogen-1

4

0

High-throughput

0.360

High

377085

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

0

High-throughput

0.347

High

1349738

CMAP3
Ciliary microtubule-associated protein 3

3

0

High-throughput

0.347

High

1430897

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

1244444

CP087
UPF0547 protein C16orf87

3

0

High-throughput

0.345

High

1339396

GP156
Probable G-protein coupled receptor 156

3

0

High-throughput

0.345

High

1429688

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

419198

H2A1B
Histone H2A type 1-B/E

2

0

High-throughput

0.318

High

587211

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

1206198

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1325836

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1326667

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1357419

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.279

Low

1398204

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1420495

FOXQ1
Forkhead box protein Q1

1

0

High-throughput

0.279

Low

1430905

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

342317

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.249

Low

351289

TTLL1
Polyglutamylase complex subunit TTLL1

1

0

High-throughput

0.249

Low

412585

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1135810

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.249

Low

1194085

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1241955

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1250196

LRC31
Leucine-rich repeat-containing protein 31

1

0

High-throughput

0.249

Low

1252224

SYNE3
Nesprin-3

1

0

High-throughput

0.249

Low

1255485

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276770

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1331559

CE120
Centrosomal protein of 120 kDa

1

0

High-throughput

0.249

Low

1332893

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

1360009

LIPH
Lipase member H

1

0

High-throughput

0.249

Low

1416230

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.249

Low

1430895

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

167464

WNT9A
Protein Wnt-9a

1

0

High-throughput

0.232

Low

1243662

S27A1
Long-chain fatty acid transport protein 1

1

0

High-throughput

0.232

Low

1314943

CCD13
Coiled-coil domain-containing protein 13

1

0

Small-scale

0.232

Low

1315535

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

0

High-throughput

0.232

Low

1357247

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025