HitPredict

Interactor 1: RASH (P01112)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Ha-Ras) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: HRAS

Interactor 2: PLCL2 (Q9UPR0)
Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)
Gene: PLCL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_12~Ras
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 189 Hs			1 1127
+	Hs
		350690 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCL2_HUMAN (1-1127): 0: 1518: 100.00
+	Hs
		348580 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCD1_HUMAN (137-882): 0: 847: 36.16
+	Hs
		349987 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCD1_HUMAN (137-882): 0: 847: 36.16
+	Hs
		349202 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCD1_HUMAN (137-882): 0: 847: 36.16
+	Hs
		846022 RB11B_HUMAN (4-171): 1.34e-72: 219: 34.12		PLCD1_HUMAN (137-882): 0: 847: 36.16
+	Hs
		348942 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCB1_HUMAN (125-925): 0: 802: 28.26
+	Hs
		350581 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB1_HUMAN (125-925): 0: 802: 28.26
+	Hs
		914080 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCB4_HUMAN (127-919): 0: 812: 28.64
+	Hs
		506371 RALA_HUMAN (4-168): 3.3e-59: 185: 54.22		PLCD1_HUMAN (137-882): 0: 847: 36.16
+	Hs
		349665 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB1_HUMAN (125-925): 0: 802: 28.26
+	Hs
		348700 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCH1_HUMAN (568-921): 1.47e-94: 334: 35.96
+	Hs
		350215 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCH1_HUMAN (568-921): 1.47e-94: 334: 35.96
+	Hs
		350087 RASK_HUMAN (1-188): 2.04e-84: 248: 86.24		PLCB3_HUMAN (595-921): 2.29e-94: 330: 29.22
+	Hs
		253284 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCH2_HUMAN (587-888): 3.89e-96: 337: 40.46
+	Hs
		349256 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCB3_HUMAN (595-921): 2.29e-94: 330: 29.22
+	Hs
		348976 RASN_HUMAN (1-188): 6.47e-88: 257: 85.64		PLCE1_HUMAN (362-560): 6.85e-79: 287: 40.69
+	Hs
		580971 RB11A_HUMAN (4-178): 4.48e-74: 223: 33.90		PLCG1_HUMAN (604-907): 5.53e-91: 320: 36.48
+	Hs
		349695 RASH_HUMAN (16-189): 5.68e-73: 219: 100.00		PLCE1_HUMAN (362-560): 6.85e-79: 287: 40.69
+	Hs
		919682 RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89		PLCE1_HUMAN (362-560): 6.85e-79: 287: 40.69