Protein: TXNIP
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)

Gene: TXNIP
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q9H3M7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004857 - enzyme inhibitor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006606 - protein import into nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

495613

THIO
Thioredoxin

21

5

Small-scale

0.989

High

1306343

THIOM
Thioredoxin, mitochondrial

2

5

High-throughput

0.811

High

1330177

TXNIP
Thioredoxin-interacting protein

2

13

Small-scale

0.754

High

1294858

ITCH
E3 ubiquitin-protein ligase Itchy homolog

7

20

Small-scale

0.752

High

1327911

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

7

20

Small-scale

0.747

High

1299026

NLRP3
NACHT, LRR and PYD domains-containing protein 3

5

1

Small-scale

0.702

High

125707

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

20

Small-scale

0.667

High

1031948

MTA1
Metastasis-associated protein MTA1

3

3

Small-scale

0.667

High

1038706

HDAC1
Histone deacetylase 1

3

5

Small-scale

0.664

High

505476

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

3

6

Small-scale

0.651

High

986034

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

4

Small-scale

0.639

High

1263972

P66B
Transcriptional repressor p66-beta

3

0

Small-scale

0.638

High

182384

PER1
Period circadian protein homolog 1

2

3

High-throughput

0.628

High

270714

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

4

High-throughput

0.628

High

1201305

KBTB6
Kelch repeat and BTB domain-containing protein 6

2

7

High-throughput

0.628

High

1262068

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

7

High-throughput

0.628

High

1330181

RAD18
E3 ubiquitin-protein ligase RAD18

2

2

High-throughput

0.628

High

327706

ECD
Protein ecdysoneless homolog

2

0

Small-scale

0.625

High

1270439

HDAC2
Histone deacetylase 2

2

5

Small-scale

0.621

High

202683

TXNL1
Thioredoxin-like protein 1

1

5

Small-scale

0.618

High

1067820

PDIA6
Protein disulfide-isomerase A6

1

5

Small-scale

0.618

High

803745

BAG6
Large proline-rich protein BAG6

2

20

Small-scale

0.611

High

874172

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

4

Small-scale

0.611

High

1192211

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

20

Small-scale

0.611

High

789652

I12R1
Interleukin-12 receptor subunit beta-1

3

5

High-throughput

0.609

High

328655

MBD3
Methyl-CpG-binding domain protein 3

2

0

High-throughput

0.602

High

1115757

CRY2
Cryptochrome-2

2

0

High-throughput

0.602

High

1330195

RUVB2
RuvB-like 2

2

4

Small-scale

0.586

High

387503

P53
Cellular tumor antigen p53

2

3

Small-scale

0.584

High

504751

HSP7C
Heat shock cognate 71 kDa protein

2

4

Small-scale

0.584

High

598317

FLNA
Filamin-A

2

7

Small-scale

0.584

High

1085674

HIF1A
Hypoxia-inducible factor 1-alpha

2

2

Small-scale

0.584

High

1330203

TRAF6
TNF receptor-associated factor 6

1

9

Small-scale

0.578

High

1145632

F91A1
Protein FAM91A1

2

1

High-throughput

0.574

High

304338

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.561

High

1330205

TF3C3
General transcription factor 3C polypeptide 3

2

3

Small-scale

0.558

High

1330200

ZBT32
Zinc finger and BTB domain-containing protein 32

1

1

Small-scale

0.552

High

1330185

DDIT4
DNA damage-inducible transcript 4 protein

1

0

Small-scale

0.537

High

855822

VAV2
Guanine nucleotide exchange factor VAV2

1

4

Small-scale

0.536

High

64560

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

1

High-throughput

0.536

High

196347

PJA2
E3 ubiquitin-protein ligase Praja-2

1

6

High-throughput

0.536

High

274378

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

5

High-throughput

0.536

High

320008

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.536

High

380861

S100B
Protein S100-B

1

5

High-throughput

0.536

High

625036

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

6

High-throughput

0.536

High

642992

S10A4
Protein S100-A4

1

5

High-throughput

0.536

High

653374

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.536

High

656776

PSB5
Proteasome subunit beta type-5

1

7

High-throughput

0.536

High

800628

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

5

High-throughput

0.536

High

807839

MAP1B
Microtubule-associated protein 1B

1

14

High-throughput

0.536

High

1024594

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.536

High

1050058

SCRIB
Protein scribble homolog

1

4

High-throughput

0.536

High

1083387

RBBP7
Histone-binding protein RBBP7

1

2

High-throughput

0.536

High

1140113

PAPD7
Terminal nucleotidyltransferase 4A

1

3

High-throughput

0.536

High

1160281

PKN3
Serine/threonine-protein kinase N3

1

7

High-throughput

0.536

High

1184860

GET4
Golgi to ER traffic protein 4 homolog

1

3

High-throughput

0.536

High

1190243

NPHP3
Nephrocystin-3

1

2

High-throughput

0.536

High

1245304

PJA1
E3 ubiquitin-protein ligase Praja-1

1

5

High-throughput

0.536

High

1295169

MAGD4
Melanoma-associated antigen D4

1

4

High-throughput

0.536

High

1296992

KI16B
Kinesin-like protein KIF16B

1

3

High-throughput

0.536

High

1299631

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

20

High-throughput

0.536

High

1303926

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

High-throughput

0.536

High

1305766

METH
Methionine synthase

1

1

High-throughput

0.536

High

1318094

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.536

High

1318937

ZCHC2
Zinc finger CCHC domain-containing protein 2

1

2

High-throughput

0.536

High

1330184

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.536

High

1330197

E41L3
Band 4.1-like protein 3

1

8

High-throughput

0.536

High

1330201

DCAF1
DDB1- and CUL4-associated factor 1

1

6

High-throughput

0.536

High

782384

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

1295595

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.513

High

1080898

HSPB2
Heat shock protein beta-2

1

4

High-throughput

0.508

High

1330179

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

High-throughput

0.508

High

177380

HDAC3
Histone deacetylase 3

1

5

Small-scale

0.501

High

523148

SRC
Proto-oncogene tyrosine-protein kinase Src

1

9

Small-scale

0.501

High

659048

MK01
Mitogen-activated protein kinase 1

1

6

Small-scale

0.501

High

1025213

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

4

Small-scale

0.501

High

265036

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.489

High

1014498

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.489

High

1072717

UBE3C
Ubiquitin-protein ligase E3C

1

20

High-throughput

0.489

High

1168348

SCAR5
Scavenger receptor class A member 5

1

1

High-throughput

0.489

High

1298517

DOCK7
Dedicator of cytokinesis protein 7

1

2

High-throughput

0.489

High

1044574

FHL1
Four and a half LIM domains protein 1

1

0

High-throughput

0.486

High

382148

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.481

High

932867

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.481

High

1330182

INT9
Integrator complex subunit 9

1

2

Small-scale

0.481

High

162151

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

10

Small-scale

0.479

High

163267

XPO1
Exportin-1

1

11

Small-scale

0.479

High

199826

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

Small-scale

0.479

High

232503

KDM1A
Lysine-specific histone demethylase 1A

1

4

Small-scale

0.479

High

311623

SMC2
Structural maintenance of chromosomes protein 2

1

4

Small-scale

0.479

High

312386

IPO7
Importin-7

1

13

Small-scale

0.479

High

320909

HS74L
Heat shock 70 kDa protein 4L

1

8

Small-scale

0.479

High

321635

AP2A1
AP-2 complex subunit alpha-1

1

12

Small-scale

0.479

High

338969

EGFR
Epidermal growth factor receptor

1

8

Small-scale

0.479

High

428426

TBB5
Tubulin beta chain

1

9

Small-scale

0.479

High

432257

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

438523

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.479

High

455865

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

514075

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

Small-scale

0.479

High

518926

TPR
Nucleoprotein TPR

1

7

Small-scale

0.479

High

533343

PLST
Plastin-3

1

5

Small-scale

0.479

High

538398

ENPL
Endoplasmin

1

4

Small-scale

0.479

High

571057

PYRG1
CTP synthase 1

1

1

Small-scale

0.479

High

592490

RAB5A
Ras-related protein Rab-5A

1

4

Small-scale

0.479

High

596321

FILA
Filaggrin

1

12

Small-scale

0.479

High

618711

IF4B
Eukaryotic translation initiation factor 4B

1

7

Small-scale

0.479

High

637554

PSA1
Proteasome subunit alpha type-1

1

1

Small-scale

0.479

High

637743

PSA2
Proteasome subunit alpha type-2

1

3

Small-scale

0.479

High

656313

PSA5
Proteasome subunit alpha type-5

1

3

Small-scale

0.479

High

672298

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

11

Small-scale

0.479

High

685022

STIP1
Stress-induced-phosphoprotein 1

1

1

Small-scale

0.479

High

709050

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

714408

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

730356

PRS7
26S proteasome regulatory subunit 7

1

4

Small-scale

0.479

High

787305

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

12

Small-scale

0.479

High

821891

HSP13
Heat shock 70 kDa protein 13

1

11

Small-scale

0.479

High

863556

COPA
Coatomer subunit alpha

1

2

Small-scale

0.479

High

871476

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

4

Small-scale

0.479

High

893156

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.479

High

924409

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

15

Small-scale

0.479

High

929658

RACK1
Small ribosomal subunit protein RACK1

1

4

Small-scale

0.479

High

933970

TBB4B
Tubulin beta-4B chain

1

9

Small-scale

0.479

High

934473

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.479

High

943483

TCPB
T-complex protein 1 subunit beta

1

1

Small-scale

0.479

High

958125

RBM10
RNA-binding protein 10

1

7

Small-scale

0.479

High

978894

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

998182

NCBP1
Nuclear cap-binding protein subunit 1

1

4

Small-scale

0.479

High

999669

AHNK
Neuroblast differentiation-associated protein AHNAK

1

4

Small-scale

0.479

High

1016243

FOXO1
Forkhead box protein O1

1

1

Small-scale

0.479

High

1029864

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.479

High

1037389

TBB3
Tubulin beta-3 chain

1

9

Small-scale

0.479

High

1043580

CUL4B
Cullin-4B

1

5

Small-scale

0.479

High

1052313

SRC8
Src substrate cortactin

1

13

Small-scale

0.479

High

1060919

IMB1
Importin subunit beta-1

1

20

Small-scale

0.479

High

1061244

NUMA1
Nuclear mitotic apparatus protein 1

1

7

Small-scale

0.479

High

1063283

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

16

Small-scale

0.479

High

1069650

STK38
Serine/threonine-protein kinase 38

1

10

Small-scale

0.479

High

1088432

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

7

Small-scale

0.479

High

1117793

Q4LE69
1-phosphatidylinositol 4-kinase

1

13

High-throughput

0.479

High

1126041

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

6

Small-scale

0.479

High

1133483

UBR4
E3 ubiquitin-protein ligase UBR4

1

7

Small-scale

0.479

High

1136505

TTBK1
Tau-tubulin kinase 1

1

10

Small-scale

0.479

High

1164705

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

Small-scale

0.479

High

1175176

TBA1A
Tubulin alpha-1A chain

1

12

Small-scale

0.479

High

1183358

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

Small-scale

0.479

High

1187775

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

1

Small-scale

0.479

High

1205723

HOME1
Homer protein homolog 1

1

1

Small-scale

0.479

High

1206196

HORN
Hornerin

1

12

Small-scale

0.479

High

1269601

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

1272607

CSN5
COP9 signalosome complex subunit 5

1

1

Small-scale

0.479

High

1273726

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

Small-scale

0.479

High

1281387

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1305092

DNJC7
DnaJ homolog subfamily C member 7

1

1

Small-scale

0.479

High

1309493

TBA1C
Tubulin alpha-1C chain

1

12

Small-scale

0.479

High

1312807

TBB6
Tubulin beta-6 chain

1

9

Small-scale

0.479

High

1317887

GTPB4
GTP-binding protein 4

1

3

Small-scale

0.479

High

1319049

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

10

Small-scale

0.479

High

1330188

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

Small-scale

0.479

High

1330191

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

Small-scale

0.479

High

1330192

YETS2
YEATS domain-containing protein 2

1

3

Small-scale

0.479

High

1330193

MAGD2
Melanoma-associated antigen D2

1

4

Small-scale

0.479

High

1330196

RUVB1
RuvB-like 1

1

4

Small-scale

0.479

High

1330199

NOP58
Nucleolar protein 58

1

4

Small-scale

0.479

High

658733

SMCA1
Probable global transcription activator SNF2L1

1

3

High-throughput

0.470

High

175445

SIVA
Apoptosis regulatory protein Siva

1

0

Small-scale

0.460

High

306594

SCEL
Sciellin

1

0

Small-scale

0.460

High

1047069

IDI1
Isopentenyl-diphosphate Delta-isomerase 1

1

0

Small-scale

0.460

High

1330180

CBX8
Chromobox protein homolog 8

1

0

Small-scale

0.460

High

1330189

UXT
Protein UXT

1

0

Small-scale

0.460

High

243603

DNJA2
DnaJ homolog subfamily A member 2

1

0

Small-scale

0.458

High

390524

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

Small-scale

0.458

High

393344

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

Small-scale

0.458

High

517462

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.458

High

772161

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

804153

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

Small-scale

0.458

High

837087

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

873874

IF5
Eukaryotic translation initiation factor 5

1

0

Small-scale

0.458

High

942251

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

984026

ZBT16
Zinc finger and BTB domain-containing protein 16

1

0

Small-scale

0.458

High

1158318

CDC73
Parafibromin

1

0

Small-scale

0.458

High

1198062

KAISO
Transcriptional regulator Kaiso

1

0

Small-scale

0.458

High

1330178

STEEP
STING ER exit protein

1

0

Small-scale

0.458

High

1330198

RRP44
Exosome complex exonuclease RRP44

1

0

Small-scale

0.458

High

787687

PI4KA
Phosphatidylinositol 4-kinase alpha

1

14

High-throughput

0.445

High

308257

LC7L3
Luc7-like protein 3

1

4

Small-scale

0.439

High

518484

ADT3
ADP/ATP translocase 3

1

1

Small-scale

0.437

High

627364

MCM3
DNA replication licensing factor MCM3

1

6

Small-scale

0.437

High

729690

VGFR2
Vascular endothelial growth factor receptor 2

1

4

Small-scale

0.437

High

940747

NOP14
Nucleolar protein 14

1

4

Small-scale

0.437

High

941824

RBM6
RNA-binding protein 6

1

10

Small-scale

0.437

High

946609

DCD
Dermcidin

1

1

Small-scale

0.437

High

1263017

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

4

Small-scale

0.437

High

1330183

ATD3A
ATPase family AAA domain-containing protein 3A

1

4

Small-scale

0.437

High

1262817

PHIP
PH-interacting protein

1

3

High-throughput

0.407

High

1330186

DCA16
DDB1- and CUL4-associated factor 16

2

0

High-throughput

0.328

High

225048

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.279

Low

1016432

TF3C1
General transcription factor 3C polypeptide 1

1

0

High-throughput

0.279

Low

1148613

C19L1
CWF19-like protein 1

1

0

High-throughput

0.279

Low

1285141

RGMA
Repulsive guidance molecule A

1

0

High-throughput

0.279

Low

1302167

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1330187

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low

256577

ZC11A
Zinc finger CCCH domain-containing protein 11A

1

0

Small-scale

0.249

Low

297547

TOX4
TOX high mobility group box family member 4

1

0

Small-scale

0.249

Low

437470

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.249

Low

1020085

IRAG2
Inositol 1,4,5-triphosphate receptor associated 2

1

0

Small-scale

0.249

Low

1076354

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

Small-scale

0.249

Low

1329600

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

Small-scale

0.249

Low

1330190

S30BP
SAP30-binding protein

1

0

Small-scale

0.249

Low

1330194

SCML2
Sex comb on midleg-like protein 2

1

0

Small-scale

0.249

Low

1330202

TCAF1
TRPM8 channel-associated factor 1

1

0

Small-scale

0.249

Low

1330204

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024