HitPredict

Interactor 1: RASK (P01116)
GTPase KRas (EC 3.6.5.2) (K-Ras 2) (Ki-Ras) (c-K-ras) (c-Ki-ras) [Cleaved into: GTPase KRas, N-terminally processed]
Gene: KRAS

Interactor 2: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	30639242, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~fn3
Common GO terms	GO:0005737 - cytoplasm GO:0005741 - mitochondrial outer membrane GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 189 Hs			1 986
+	Hs
		349222 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA4_HUMAN (1-986): 0: 1293: 100.00
+	Hs
		348673 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA7_HUMAN (5-986): 0: 1212: 62.37
+	Hs
		1070202 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA7_HUMAN (5-986): 0: 1212: 62.37
+	Hs
		348528 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA3_HUMAN (26-986): 0: 1182: 63.01
+	Hs
		665398 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA3_HUMAN (26-986): 0: 1182: 63.01
+	Hs
		665604 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB2_HUMAN (30-983): 0: 1169: 58.47
+	Hs
		349144 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		348527 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		665242 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHA2_HUMAN (27-986): 0: 1059: 50.36
+	Hs
		872534 RAB35_HUMAN (4-187): 1.09e-82: 244: 31.28		EPHB4_HUMAN (14-977): 0: 1028: 49.90
+	Hs
		349123 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		EPHA1_HUMAN (17-973): 0: 970: 43.87
+	Hs
		349876 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		EPHA1_HUMAN (17-973): 0: 970: 43.87
+	Hs
		349065 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		INSR_HUMAN (284-902): 1.29e-145: 470: 25.00
+	Hs
		348472 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		INSR_HUMAN (284-902): 1.29e-145: 470: 25.00
+	Hs
		349800 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		INSR_HUMAN (284-902): 1.29e-145: 470: 25.00
+	Hs
		349808 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47
+	Hs
		349066 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		FYN_HUMAN (615-879): 2.51e-66: 234: 44.20
+	Hs
		349095 RASH_HUMAN (1-188): 6.53e-87: 255: 86.77		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42
+	Hs
		348488 RASN_HUMAN (1-189): 2.37e-85: 251: 85.19		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42
+	Hs
		349836 RASK_HUMAN (1-189): 8.4e-77: 229: 100.00		SRC_HUMAN (601-871): 2.14e-64: 229: 45.42