Protein: PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (EC 3.1.4.11) (Phosphoinositide phospholipase C-gamma-2) (Phospholipase C-IV) (PLC-IV) (Phospholipase C-gamma-2) (PLC-gamma-2)

Gene: PLCG2
Organism: Homo sapiens
Interactions: 83
UniProt ID: P16885

Gene Ontology (top 5):
GO:0001775 - cell activation
GO:0001784 - phosphotyrosine residue binding
GO:0001878 - response to yeast
GO:0002092 - positive regulation of receptor internalization
GO:0002223 - stimulatory C-type lectin receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

362717

EGFR
Epidermal growth factor receptor

5

20

High-throughput

0.928

High

463320

LYN
Tyrosine-protein kinase Lyn

3

17

Small-scale

0.875

High

410595

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

413142

P53
Cellular tumor antigen p53

2

4

High-throughput

0.767

High

599272

SHC1
SHC-transforming protein 1

2

13

Small-scale

0.754

High

599276

KSYK
Tyrosine-protein kinase SYK

2

20

Small-scale

0.754

High

599285

BTK
Tyrosine-protein kinase BTK

2

16

Small-scale

0.754

High

599292

RBP1
RalA-binding protein 1

2

4

High-throughput

0.743

High

599304

ASB9
Ankyrin repeat and SOCS box protein 9

2

1

High-throughput

0.743

High

599271

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

6

Small-scale

0.724

High

164848

SH21B
SH2 domain-containing protein 1B

1

20

Small-scale

0.710

High

471978

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532042

KIT
Mast/stem cell growth factor receptor Kit

1

18

High-throughput

0.692

High

599288

GAB1
GRB2-associated-binding protein 1

1

4

High-throughput

0.692

High

599302

BLNK
B-cell linker protein

1

6

Small-scale

0.691

High

599306

EPYC
Epiphycan

2

1

High-throughput

0.686

High

599301

GABP2
GA-binding protein subunit beta-2

2

2

High-throughput

0.665

High

578368

BRAF
Serine/threonine-protein kinase B-raf

1

6

High-throughput

0.653

High

440346

FYN
Tyrosine-protein kinase Fyn

1

17

Small-scale

0.647

High

599266

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.647

High

599277

BLK
Tyrosine-protein kinase Blk

1

17

Small-scale

0.647

High

599291

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

19

High-throughput

0.647

High

599293

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.646

High

220348

LAT
Linker for activation of T-cells family member 1

2

2

Small-scale

0.629

High

240677

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.618

High

253291

JAK2
Tyrosine-protein kinase JAK2

1

20

Small-scale

0.618

High

541319

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

584463

VAV
Proto-oncogene vav

1

6

Small-scale

0.618

High

599262

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

5

Small-scale

0.618

High

599263

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.618

High

599268

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.618

High

599270

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

High-throughput

0.618

High

599281

GRB2
Growth factor receptor-bound protein 2

1

17

High-throughput

0.618

High

599284

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

5

Small-scale

0.618

High

599287

PLD1
Phospholipase D1

1

2

Small-scale

0.618

High

599290

KPCD1
Serine/threonine-protein kinase D1

1

5

Small-scale

0.618

High

599310

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.618

High

599312

GAB2
GRB2-associated-binding protein 2

1

5

Small-scale

0.618

High

210850

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

0

High-throughput

0.601

High

599264

EPOR
Erythropoietin receptor

1

7

Small-scale

0.590

High

599278

EPHA4
Ephrin type-A receptor 4

1

13

High-throughput

0.590

High

529017

TAU
Microtubule-associated protein tau

2

5

Small-scale

0.584

High

599279

ISL1
Insulin gene enhancer protein ISL-1

2

1

High-throughput

0.576

High

599299

KCD17
BTB/POZ domain-containing protein KCTD17

2

3

High-throughput

0.576

High

599303

TWST2
Twist-related protein 2

2

2

High-throughput

0.576

High

599282

3BP2
SH3 domain-binding protein 2

1

1

Small-scale

0.575

High

353789

PTTG1
Securin

2

0

High-throughput

0.569

High

532341

CH60
60 kDa heat shock protein, mitochondrial

2

0

High-throughput

0.569

High

599313

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.553

High

532206

ESTD
S-formylglutathione hydrolase

2

0

High-throughput

0.551

High

599296

LHX8
LIM/homeobox protein Lhx8

2

1

High-throughput

0.542

High

519718

ANDR
Androgen receptor

1

4

High-throughput

0.536

High

599267

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.536

High

599274

IRS1
Insulin receptor substrate 1

1

4

Small-scale

0.527

High

599314

RA54B
DNA repair and recombination protein RAD54B

1

4

High-throughput

0.504

High

599307

CD244
Natural killer cell receptor 2B4

1

4

Small-scale

0.501

High

583960

CD19
B-lymphocyte antigen CD19

1

0

Small-scale

0.480

High

208113

PLXB1
Plexin-B1

1

6

Small-scale

0.479

High

330642

KI20A
Kinesin-like protein KIF20A

1

5

High-throughput

0.479

High

371090

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

599286

CBLB
E3 ubiquitin-protein ligase CBL-B

1

2

Small-scale

0.479

High

599289

SRC8
Src substrate cortactin

1

3

Small-scale

0.479

High

599295

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

599308

NTAL
Linker for activation of T-cells family member 2

1

1

Small-scale

0.479

High

599305

Z512B
Zinc finger protein 512B

1

2

High-throughput

0.464

High

123324

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

320619

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

599273

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

Small-scale

0.458

High

599280

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

599297

BCAP
Phosphoinositide 3-kinase adapter protein 1

1

0

Small-scale

0.458

High

248193

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

599294

HS904
Putative heat shock protein HSP 90-alpha A4

1

3

High-throughput

0.445

High

587861

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

599269

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

599275

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

599265

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.310

High

599298

BOP
Protein Bop

2

0

High-throughput

0.300

High

599300

SETD9
SET domain-containing protein 9

2

0

High-throughput

0.300

High

599311

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

2

0

High-throughput

0.300

High

599283

S35A2
UDP-galactose translocator

1

0

High-throughput

0.279

Low

326174

FSBP
Fibrinogen silencer-binding protein

1

0

High-throughput

0.264

Low

599309

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025